Results 51 to 60 of about 4,135 (231)

Double‐blind placebo‐controlled study of testosterone patch therapy on bone turnover in men with borderline hypogonadism [PDF]

International Journal of Andrology, 2005
SummaryClinical studies suggest there may be a threshold concentration of serum testosterone below which replacement will result in skeletal and psychological benefit. We evaluated the response to testosterone in men with borderline hypogonadism. A randomized double‐blind placebo‐controlled trial in 39 men over age 40 years presenting with sexual ...
Merza, Z., Blumsohn, A., Mah, P. M., Meads, D. M., McKenna, S. P., Wylie, K., Eastell, R., Wu, F., Ross, R. J M   +8 more
openaire   +4 more sources

Protective effects of allicin against stanozolol‐induced cardiotoxicity: Physiological and histopathological evidence in a rabbit model

Animal Models and Experimental Medicine, EarlyView.
There are many forms of anabolic steroids, including stanzolo (Winstrol), which are popular for their muscle‐building effects but dangerous to the heart. This present work is aimed at evaluating the pharmacological impact of allacin, a natural attribute obtained from garlic on obstructing cardiac injury in rabbits that received stanzolo.
Mohammed Hayder Asker, Noor AL‐Huda Salah AL‐Zuhairy, Wassan Mhammed Husain, Mustafa Riyadh Abdullah   +3 more
wiley   +1 more source

μ‐Opioid Receptor Dynamics in the Parameningeal Tissue During Migraine Attacks

Annals of Neurology, EarlyView.
Objective The possible impact of meningeal μ‐opioid receptor (μOR) binding in migraine remains unknown. This study investigated μOR availability in the cranial parameninges involved in migraine initiation via nociceptor activation. Methods We used positron emission tomography with [11C] carfentanil, and measured μOR availability in meninges and ...
Dajung J. Kim, Manyoel Lim, Thiago D. Nascimento, Frank Porreca, Robert A. Koeppe, Nouchine Hadjikhani, Alexandre F. DaSilva   +6 more
wiley   +1 more source

Ethnomedicinal Uses, Phytochemistry, Pharmacological Activities, and Toxicology of the Subfamily Gomphrenoideae (Amaranthaceae): A Comprehensive Review

Chemistry &Biodiversity, EarlyView.
ABSTRACT The subfamily Gomphrenoideae is composed of about 480 accepted species, many of which have been historically used as medicinal plants, reason why they have been studied in terms of chemical profile, biological activity, and safety. This review consolidates the advances in research on this subfamily over the past 47 years, emphasizing its ...
Dayanna Isabel Araque Gelves, Giulia Cristina de Andreoli Souza, Alvaro Jose Hernandez Tasco, Marcos José Salvador   +3 more
wiley   +1 more source

Diclofenac Detection via Inner‐Filter Effect Using Pyridine‐Modified Triphenylene

ChemPlusChem, EarlyView.
The synthesis of hexa‐pyridine triphenylene derivatives via Suzuki‐coupling reaction and their application toward the sensing of diclofenac have been studied for the first time. The 3PY and 4PY are selective for diclofenac over the other commonly prescribed pharmaceuticals and hormones tested. Triphenylene derivatives 3PY (2,3,6,7,10,11‐hexa(pyridine‐3‐
Navdeep Kajal, Amar Raj, Rajendhraprasad Tatikonda, Jan Lundell, Matti Haukka   +4 more
wiley   +1 more source

The Impact of Triptorelin on Hormone Levels in Human and Its Metabolite Confirmation Using Liquid Chromatography–Ion Trap/Time‐of‐Flight Mass Spectrometry (LC/MS‐IT‐TOF) and Liquid Chromatography–Orbitrap (LC‐Orbitrap) for Doping Control Analysis

Drug Testing and Analysis, EarlyView.
Triptorelin (5–10) confirmation using LC/MS‐IT‐TOF and LC‐Orbitrap can be used as evidence of triptorelin abuse in doping control. ABSTRACT Triptorelin, a synthetic gonadotrophin‐releasing hormone (GnRH), is mainly used in the clinical treatment of prostate cancer.
Navaporn Saardpun, Cholsittapan Asawesna, Seksun Kaewklam, Premsant Sangkhum, Wisoot Kongchareonsombat, Thanit Kusamran, Darawan Pinthong   +6 more
wiley   +1 more source

Genetic association between microRNA gene polymorphisms and polycystic ovary syndrome susceptibility: A systematic review and meta‐analysis

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Background Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder in women of reproductive age, associated with genetic and environmental factors, including microRNA (miRNA) gene polymorphisms. Objective To evaluate the association between miRNA gene polymorphisms and PCOS. Search Strategy PubMed, Embase, Web of Science, and Scopus
Amaxsell Thiago Barros de Souza, Ketelly Leônara da Silva Torres, Ayane Cristine Alves Sarmento, Ariadne Sarynne Barbosa de Lima, Kleyton Santos de Medeiros, Deyse de Souza Dantas, Ricardo Ney Cobucci, Ana Katherine Gonçalves, Janaina Cristiana de Oliveira Crispim   +8 more
wiley   +1 more source

Gut microbial‐derived 3,4‐dihydroxyphenylacetic acid ameliorates reproductive phenotype of polycystic ovary syndrome

iMeta, EarlyView.
By integrating multi‐level and multi‐omics analyses, we identify 3,4‐dihydroxyphenylacetic acid (DHPAA), a gut microbiota‐derived degradation product of dietary flavonoids, as a key bioactive end‐product responsible for the beneficial effects against polycystic ovary syndrome (PCOS).
Pan Li, Li Xie, Huimin Zheng, Yinglin Feng, Feihong Mai, Wenli Tang, Jiajia Wang, Zixin Lan, Shuaijun Lv, Thisun Jayawardana, Sabrina Koentgen, Shuangbin Xu, Zhengwei Wan, Yunjie Chen, Haiyan Xu, Sj Shen, Fan Zhang, Yuanhao Yang, Georgina Hold, Fangjie He, Emad M. El‐Omar, Guangchuang Yu, Xia Chen   +22 more
wiley   +1 more source

A Novel Male Contraceptive Pill-Patch Combination: Oral Desogestrel and Transdermal Testosterone in the Suppression of Spermatogenesis in Normal Men [PDF]

, 2001
W. Morton Hair, Kay Kitteridge, Daryl B. O’Connor, Frederick C. W. Wu   +3 more
openalex   +2 more sources

Pyriproxyfen Disrupts the Ongoing Spermatogenesis Wave in Danio rerio Potentially Mediated by Voltage‐Dependent Calcium Channels and Protein Kinase C

Journal of Applied Toxicology, EarlyView.
ABSTRACT Pyriproxyfen (PPX) is an analog of the juvenile hormone from insects. Following our previous studies, for the ex vivo short‐term effect, we chose 10−9 M pyriproxyfen to analyze the morphology of spermatogenesis wave cells. In silico docking and ADMET (Absorption, Distribution, Metabolism, Excretion, Toxicity) studies were carried out to ...
Bruna Antunes Zaniboni, Vanessa Staldoni de Oliveira, Gabriel Adan Araujo Leite, Valdelúcia Maria Alves de Souza Grinevicius, Rozangela Curi Pedrosa, Fátima Regina Mena Barreto Silva   +5 more
wiley   +1 more source