Results 201 to 210 of about 236,531 (317)

The Efficacy and Adverse Events of Testosterone Replacement Therapy in Hypogonadal Men: A Systematic Review and Meta-Analysis of Randomized, Placebo-Controlled Trials

Journal of Clinical Endocrinology and Metabolism, 2018
O. Ponce, Gabriela Spencer‐Bonilla, Neri Alvarez-Villalobos, Valentina Serrano, Naykky M. Singh-Ospina, R. Rodríguez‐Gutiérrez, Alejandro Salcido-Montenegro, R. Benkhadra, L. Prokop, S. Bhasin, J. Brito   +10 more
semanticscholar   +1 more source

Annual Banned‐Substance Review 18th Edition—Analytical Approaches in Human Sports Drug Testing 2024/2025

Drug Testing and Analysis, Volume 18, Issue 4, Page 458-482, April 2026.
New insights into drug metabolism, distribution, elimination, and detection assays for drugs and methods of sports doping published between 2024 and 2025 are critically reviewed and evaluated in context with the Prohibited List 2025 as established by the World Anti‐Doping Agency.
Mario Thevis, Tiia Kuuranne, Hans Geyer
wiley   +1 more source

Cardiovascular Effects of Testosterone Replacement Therapy in Hypogonadal Men: A Systematic Review of Lipid Profiles, Inflammatory Markers, and Vascular Function. [PDF]

Cureus
Ezeamii PC, Adebayo AA, Ozojide KO, Kutin Siaw T, Ghartey KK, Umana I, Arinzechi CI, Enyeneokpon E, Oguntuase FO, Okobi OE.   +9 more
europepmc   +1 more source

Unraveling Chronic Pain: From Mechanisms and Risks to Diagnosis and Treatment

MedComm, Volume 7, Issue 4, April 2026.
Chronic pain arises through distinct molecular pathways categorized into nociceptive, neuropathic, and nociplastic types. Nociceptive pain begins with TRP channel activation in peripheral nociceptors, signaling via Aδ‐ and C‐fibers through the spinal dorsal horn and spinothalamic tracts to the brain, regulated by descending inhibition and involving ...
Xiaofeng Dai, Chongxiang Wang, Ping Jiang, Xiaopeng Mei   +3 more
wiley   +1 more source

Steroid Recognition in Adhesion GPCRs: A Structural and Pharmacological Perspective

Pharmacology Research &Perspectives, Volume 14, Issue 2, April 2026.
ABSTRACT Emerging evidence suggests steroids may act as generalizable ligands for adhesion GPCRs, a receptor class with considerable pharmacological potential. While most studies have focused on the ADGR‘G' subfamily, recent cryo‐EM structures of the androgens 5α‐dihydrotestosterone (5α‐DHT) and methenolone bound to ADGRD1 revealed a putative steroid ...
Bethany Fleming, Abdul‐Akim Guseinov, Irina G. Tikhonova, Graeme Milligan, Nicole A. Perry‐Hauser   +4 more
wiley   +1 more source

Preoperative testosterone replacement therapy: a potential risk-factor for complications and reoperation after rotator cuff repair. [PDF]

JSES Int
Johnson AH, Friedman R, Brennan JC, Peterman MA, Gelfand J, Redziniak DE, Lashgari C, Turcotte JJ.   +7 more
europepmc   +1 more source

Is Testosterone Replacement Therapy in Older Men Effective and Safe?

Drugs & Aging, 2019
A. Yabluchanskiy, P. Tsitouras
semanticscholar   +1 more source

A concept for a new approach to combined oral contraception from adolescence to perimenopause: Continuous use of the oral GnRH antagonist Relugolix and the fetal estrogen Estetrol

Acta Obstetricia et Gynecologica Scandinavica, Volume 105, Issue 4, Page 568-574, April 2026.
It is expected that the relugolix estetrol combination RE4W will enable women to control their fertility and prevent menstrual cycle related problems, while offering a smooth transition through perimenopause into the postmenopause and decrease the risk of breast cancer.
Herjan J. T. Coelingh Bennink, Karolina Afors, Luis Bahamondes, Alessandra Graziottin, Deborah Bateson, Teresa Bombas, Yutaki Osuga, Santiago Palacios, Carolyn L. Westhoff, Kristina Gemzell‐Danielsson   +9 more
wiley   +1 more source

Obesity-Related Cancers in Relation to Use of Statins and Testosterone Replacement Therapy Among Older Women: SEER-Medicare 2007-2015. [PDF]

Pharmaceuticals (Basel)
Hussain MR, Wu S, Saab D, Digbeu B, Abdelgadir O, Hernandez-Perez JG, Torres-Sanchez LE, Leonard T, Cano M, Kuo YF, Villasante-Tezanos A, Lopez DS.   +11 more
europepmc   +1 more source

Homo sapiens, industrialisation and the environmental mismatch hypothesis

Biological Reviews, Volume 101, Issue 2, Page 580-601, April 2026.
ABSTRACT For the vast majority of the evolutionary history of Homo sapiens, a range of natural environments defined the parameters within which selection shaped human biology. Although human‐induced alterations to the terrestrial biosphere have been evident for over 10,000 years, the pace and scale of change has accelerated dramatically since the onset
Daniel P. Longman, Colin N. Shaw
wiley   +1 more source