Identification of Novel tet(X3) Variants Resistant To Tigecycline in Acinetobacter Species [PDF]
Microbiology Spectrum, 2022 The emergence of the tet(X) gene is a severe challenge to global public health security, as clinical tigecycline resistance shows a rapidly rising trend. In this research, we identified two tigecycline-resistant Acinetobacter sp. strains containing seven
Yumeng Cheng +5 more
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A novel inhibitor of monooxygenase reversed the activity of tetracyclines against tet(X3)/tet(X4)-positive bacteria [PDF]
EBioMedicine, 2022 Summary: Background: Tigecycline is one of the few last-resort antibiotics for the treatment of carbapenem-resistant Enterobacteriaceae infection, the incidence of which has been rapidly increasing.
Lei Xu +11 more
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Sporadic Dissemination of tet(X3) and tet(X6) Mediated by Highly Diverse Plasmidomes among Livestock-Associated Acinetobacter [PDF]
Microbiology Spectrum, 2021 The emergence of high-level tigecycline resistance mediated by plasmid-borne tet(X) genes greatly threatens the clinical effectiveness of tigecycline. However, the dissemination pattern of plasmid-borne tet(X) genes remains unclear. We here recovered tet(
Ying-Ying Cheng +6 more
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Occurrence and Characterization of NDM-1-Producing Shewanella spp. and Acinetobacter portensis Co-Harboring tet(X3) in a Chinese Dairy Farm [PDF]
Antibiotics, 2022 Bacteria with carbapenem or tigecycline resistance have been spreading widely among humans, animals and the environment globally, being great threats to public health.
Ruichao Li +7 more
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Characterization of Three Porcine Acinetobacter towneri Strains Co-Harboring tet(X3) and blaOXA-58 [PDF]
Frontiers in Cellular and Infection Microbiology, 2020 Tigecycline is the antibiotic of last resort for the treatment of extensively drug-resistant bacterial infections, mainly those of multidrug-resistant Gram-negative bacteria.
Jiangang Ma +9 more
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Innovative application of mefloquine and Methacycline in combating Tet(X3/X4)-positive Escherichia coli infections [PDF]
BMC MicrobiologyThe advent and global spread of plasmid-carried resistance genes, including the tigecycline resistance gene tet(X3/X4) and the colistin resistance gene mcr-1, present a substantial threat to public health that requires immediate resolution.
Qianyu Zhou +7 more
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Exogenous adenosine counteracts tigecycline resistance in tet(X3)-harboring Escherichia coli [PDF]
Microbiology SpectrumThe rapid spread of antibiotic resistance poses a global health crisis. Tigecycline is a last-resort antibiotic, but the recent emergence of the plasmid-borne tet(X3) gene conferring high-level tigecycline resistance is deeply concerning. Here, we report
Jing Sun +14 more
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Earliest observation of the tetracycline destructase tet(X3) [PDF]
Microbiology SpectrumTigecycline is an antibiotic of last resort for infections with carbapenem-resistant Acinetobacter baumannii. Plasmids harboring variants of the tetracycline destructase gene tetX promote rising tigecycline resistance rates.
Frédéric Grenier +3 more
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Transfer and Fitness of ISAba52-Mediated tet(X3) Transposon in Acinetobacter spp. [PDF]
MicroorganismsThe global spread of tigecycline resistance conferred by tet(X3) poses a serious threat to clinical treatment of multidrug-resistant (MDR) Acinetobacter infections.
Chong Chen +5 more
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A strain defined as a novel species in the Acinetobacter genus co-harboring chromosomal associated tet(X3) and plasmid associated blaNDM-1 from a beef cattle farm in Hebei, China [PDF]
Frontiers in Cellular and Infection MicrobiologyIntroductionThe co-existence phenomenon of antibiotic resistance genes (ARGs), particularly of last-resort antibiotics in multi-drug resistant (MDR) bacteria, is of particular concern in the least studied bacterial species.MethodsIn 2023, strain M2 was ...
Qing Wang +29 more
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