Results 21 to 30 of about 12,901 (148)

Nosocomial transmission of tet(x3), bla _NDM-1 and bla _OXA-97-carrying Acinetobacter baumannii conferring resistance to eravacycline and omadacycline, the Netherlands, March to August 2021. [PDF]

Euro Surveill
Talsma DT, Monteiro R, Flores-Vallejo RDC, Heuvelmans M, Le TN, Hendrickx AP, Rosema S, Maat I, van Dijl JM, Bathoorn E.   +9 more
europepmc   +3 more sources

Advances in mechanism study on novel tetracycline-inactivating enzymes tet(X) causing emerging tigecycline resistance [PDF]

Zhenduanxue lilun yu shijian, 2023
Antibiotic resistance in bacteria has become a great threat to global public health. Tigecycline is a next-generation tetracycline that is the final line of defense against severe infections by carbapenem-resistant Gram-negative bacteria.
SHEN Pinghua, CHEN Huifen
doaj   +1 more source

Classification and molecular characteristics of tet(X)-carrying plasmids in Acinetobacter species

Frontiers in Microbiology, 2022
The rapid dissemination of plasmid-mediated tet(X) genes in Acinetobacter species has compromised the clinical effectiveness of tigecycline, one of the last-resort antibiotics.
Chong Chen, Chong Chen, Chong Chen, Ping-Yu Huang, Ping-Yu Huang, Chao-Yue Cui, Qian He, Jian Sun, Jian Sun, Ya-Hong Liu, Ya-Hong Liu, Jin-Lin Huang, Jin-Lin Huang, Jin-Lin Huang   +13 more
doaj   +1 more source

A multinomial quadrivariate D-vine copula mixed model for meta-analysis of diagnostic studies in the presence of non-evaluable subjects [PDF]

, 2020
Diagnostic test accuracy studies observe the result of a gold standard procedure that defines the presence or absence of a disease and the result of a diagnostic test.
Aristidis K Nikoloulopoulos, Genest C, Nash J., Schuetz GM, Stroud AH   +4 more
core   +2 more sources

Evolutionary Trajectory of the Tet(X) Family: Critical Residue Changes towards High-Level Tigecycline Resistance

mSystems, 2021
The newly emerged tigecycline-inactivating enzymes Tet(X3) and Tet(X4), which are associated with high-level tigecycline resistance, demonstrated significantly higher activities in comparison to that of the prototypical Tet(X) enzyme, threatening the ...
Chao-Yue Cui, Qian He, Qiu-Lin Jia, Cang Li, Chong Chen, Xiao-Ting Wu, Xiao-Jing Zhang, Zhuo-Yu Lin, Zi-Jian Zheng, Xiao-Ping Liao, Barry N. Kreiswirth, Ya-Hong Liu, Liang Chen, Jian Sun   +13 more
doaj   +1 more source

A TaqMan-based multiplex real-time PCR assay for the rapid detection of tigecycline resistance genes from bacteria, faeces and environmental samples

BMC Microbiology, 2020
Background Tigecycline is a last-resort antibiotic used to treat severe infections caused by extensively drug-resistant bacteria. Recently, novel tigecycline resistance genes tet(X3) and tet(X4) have been reported, which pose a great challenge to human ...
Yiming Li, Zhangqi Shen, Shuangyang Ding, Shaolin Wang   +3 more
doaj   +1 more source

Occurrence and Molecular Characterization of Abundant tet(X) Variants Among Diverse Bacterial Species of Chicken Origin in Jiangsu, China

Frontiers in Microbiology, 2021
Many novel tigecycline-inactivating enzymes encoded by tet(X) variants from different bacteria were discovered since the plasmid-mediated tet(X3) and tet(X4) genes conferring high-level resistance to tigecycline in Enterobacterales and Acinetobacter were
Yingshan Li, Yingshan Li, Kai Peng, Kai Peng, Yi Yin, Yi Yin, Xinran Sun, Xinran Sun, Wenhui Zhang, Wenhui Zhang, Ruichao Li, Ruichao Li, Ruichao Li, Zhiqiang Wang, Zhiqiang Wang   +14 more
doaj   +1 more source

Three-Dimensional Manifolds, Skew-Gorenstein Rings and their Cohomology [PDF]

, 2010
Graded skew-commutative rings occur often in practice. Here are two examples: 1) The cohomology ring of a compact three-dimensional manifold. 2) The cohomology ring of the complement of a hyperplane arrangement (the Orlik-Solomon algebra).
Dedicated To Ralf Fröberg, Jan-erik Roos   +1 more
core   +2 more sources

Alpha‐synuclein‐associated changes in PINK1‐PRKN‐mediated mitophagy are disease context dependent

Brain Pathology, Volume 33, Issue 5, September 2023., 2023
The increase of the selective mitophagy marker pS65‐Ub in human autopsy brain is associated with neuronal Lewy body‐type, but not glial cytoplasmic inclusions of alpha‐synuclein pathology. Abstract Alpha‐synuclein (αsyn) aggregates are pathological features of several neurodegenerative conditions including Parkinson disease (PD), dementia with Lewy ...
Xu Hou, Taylor Hsuan‐Yu Chen, Shunsuke Koga, Jenny M. Bredenberg, Ayman H. Faroqi, Marion Delenclos, Guojun Bu, Zbigniew K. Wszolek, Jonathan A. Carr, Owen A. Ross, Pamela J. McLean, Melissa E. Murray, Dennis W. Dickson, Fabienne C. Fiesel, Wolfdieter Springer   +14 more
wiley   +1 more source

Detection of a new tet(X6)-encoding plasmid in Acinetobacter towneri

Journal of Global Antimicrobial Resistance, 2021
: Objectives: The aim of this study was to characterise a novel tet(X6)-carrying plasmid detected in a livestock-associated Acinetobacter towneri isolate.
Yingying Cheng, Yong Chen, Yang Liu, Jingjie Song, Yunbo Chen, Tongling Shan, Yonghong Xiao, Kai Zhou   +7 more
doaj   +1 more source