Results 11 to 20 of about 165,089 (294)

Assessing the impact of the 2018 tetanus guidelines on knowledge and practices of emergency physicians in trauma patients: a national survey study [PDF]

PeerJ, 2023
Background Tetanus remains a significant public health issue in China, with the approach of anti-tetanus prophylaxis in the emergency department resulting in both overuse, particularly of human tetanus immune globulin (TIG), and underuse with the tetanus
Junling Gao, Xiaxia Yu, Guanghui Cao, Xiaoming He, Pingde Zhang, Joseph Walline, Yuanxi Wang, Xingjuan Yu, Jun Xu, Thuan-Quoc Thach, Yong Liu   +10 more
doaj   +2 more sources

Clinical Profile, Management and Outcome in Paediatric Patients with Tetanus: A Case Series [PDF]

Journal of Clinical and Diagnostic Research, 2023
Tetanus is an acute infectious disease, caused by spores of the bacterium Clostridium tetani. The spores are found everywhere in the environment, particularly in soil, ash, intestinal tracts/faeces of animals and humans, on the surfaces of skin and rusty
Arpita Manish Patel, Dhruti Manish Pandya, Kamleshkumar G Rathod, Ketan D Gadhavi, Bharat Muliya   +4 more
doaj   +1 more source

The threat of a new tetanus outbreak due to urban flooding disaster requires vigilance: a narrative review

Acute Medicine & Surgery, 2023
Vaccines for tetanus prevention have rapidly progressed, and the number of outbreaks, especially the incidence of tetanus in developed countries, has decreased dramatically. However, the mortality rate associated with severe tetanus remains high. Tetanus
Junko Yamaguchi, Kosaku Kinoshita
doaj   +1 more source

A companion to the preclinical common data elements for rodent models of pediatric acquired epilepsy: A report of the TASK3‐WG1B, Pediatric and Genetic Models Working Group of the ILAE/AES Joint Translational Task Force

Epilepsia Open, EarlyView., 2022
Abstract Epilepsy syndromes during the early years of life may be attributed to an acquired insult, such as hypoxic–ischemic injury, infection, status epilepticus, or brain trauma. These conditions are frequently modeled in experimental rodents to delineate mechanisms of epileptogenesis and investigate novel therapeutic strategies.
Anna‐Maria Katsarou, Hana Kubova, Stéphane Auvin, Massimo Mantegazza, Melissa Barker‐Haliski, Aristea S. Galanopoulou, Christopher A. Reid, Bridgette D. Semple   +7 more
wiley   +1 more source

Development and validation of a targeted LC-MS/MS quantitation method to monitor cell culture expression of tetanus neurotoxin during vaccine production [PDF]

Talanta vol. 236 (2022): 122883, 2022
The tetanus neurotoxin (TeNT) is one of the most toxic proteins known to man, which prior to the use of the vaccine against the TeNT producing bacteria Clostridium tetani, resulted in a 20 % mortality rate upon infection. The clinical detrimental effects of tetanus have decreased immensely since the introduction of global vaccination programs, which ...
arxiv   +1 more source

Infant rhesus macaques as a non-human primate model of Bordetella pertussis infection

BMC Infectious Diseases, 2021
Background The prevalent resurgence of pertussis has recently become a critical public health problem worldwide. To understand pertussis pathogenesis and the host response to both the pathogen and vaccines, a suitable pertussis animal model, particularly
Wenwen Jiang, Chen Wei, Dachao Mou, Weilun Zuo, Jiangli Liang, Xiao Ma, Lichan Wang, Na Gao, Qin Gu, Peng Luo, Yan Ma, Jingyan Li, Shuyuan Liu, Li Shi, Mingbo Sun   +14 more
doaj   +1 more source

Immunological Responses to Tetanus and Influenza Vaccination in Donkeys. [PDF]

J Vet Intern Med
ABSTRACT Background Donkeys are routinely vaccinated with protocols developed for horses, yet species‐specific data on their immune responses are limited. Hypothesis/Objectives We hypothesized that donkeys exhibit robust T‐cell‐mediated immunity and regulatory adaptation after vaccination, comparable to horses.
Perzyna M, Grzędzicka J, Milczek-Haduch D, Dąbrowska I, Trela M, Pawliński B, Witkowska-Piłaszewicz O.   +6 more
europepmc   +2 more sources

Faktor-Faktor Yang Berhubungan Dengan Ibu Hamil Dalam Melakukan Imunisasi Tetanus Toxoid

Citra Delima, 2022
Imunisasi Tetanus Toxoid (TT) adalah toksin kuman tetanus yang telah dimurnikan yang di berikan pada bayi, anak dan ibu sebagai usaha memberikan perlindungan terhadap penyakit tetanus Imunisasi Tetanus Toxoid ini juga diberikan pada ibu hamil dan wanita ...
desti widya astuti
doaj   +1 more source

Safety and Immunogenicity of a Recombinant Tetanus Vaccine in Healthy Adults in China: A Randomized, Double‐Blind, Dose Escalation, Placebo‐ and Positive‐Controlled, Phase 1/2 Trial

Advanced Science, 2021
Tetanus is a fatal but vaccine‐preventable disease. The currently available tetanus vaccines are tetanus toxoid (TT)‐based. Although these vaccines are generally effective, challenges in vaccine development and access remain.
Xiaowei Xu, Rui Yu, Lanlan Xiao, Jie Wang, Meihong Yu, Junjie Xu, Yajun Tan, Xiao Ma, Xiaoxin Wu, Jiangshan Lian, Kaizhou Huang, Xiaoxi Ouyang, Sheng Bi, Shipo Wu, Xiaoyan Wang, Jiandi Jin, Ling Yu, Huafen Zhang, Qi Wei, Jinfa Shi, Wei Chen, Lanjuan Li   +21 more
doaj   +1 more source

Trends in neonatal and post-neonatal tetanus admissions at a Nigerian teaching hospital

Journal of Infection in Developing Countries, 2012
Introduction: Tetanus accounts for high morbidity and case fatality rates in developing countries. This study therefore aimed to identify reasons for the persistence of this disease.
Olusola Adetunji Oyedeji, Francis Fadero, Victor Joel-Medewase, Peter Elemile, Gabriel Ademola Oyedeji   +4 more
doaj   +1 more source