Fusion complex formation protects synaptobrevin against proteolysis by tetanus toxin light chain [PDF]
, 1994 The clostridial neurotoxin, tetanus toxin, is a Zn2+-dependent protease which inhibits neurotransmitter exocytosis by selective cleavage of the synaptic vesicle protein, synaptobrevin.
Betz, Heinrich +2 more
core +1 more source
Journal of Peptide Science, Volume 31, Issue 6, June 2025.Peptide‐based vaccines, formulated with an appropriate adjuvant, offer a versatile platform for targeted cancer immunotherapy. Herein, we explore the synthesis of two tissue‐restricted cancer‐testis antigens; (NY‐ESO‐1 and BAGE4) covalently linked to the toll‐like receptor agonist, Pam2Cys.
Salwa Aljohani +8 more
wiley +1 more source
Effect of synthetic and bovine milk conjugated linoleic acid (CLA) on immune function : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Nutrition Science at Massey University [PDF]
, 1999 CLA is a collective name for a mixture of positional and geometrical isomers of linoleic acid (c-9, c-12-octadecadioenic acid) which possess conjugated double bonds.
Zhao, Hui
core
The Dynamic Behavior (Effects) of Impulsive Toxicant Input on a Single-Species Population in a Small Polluted Environment [PDF]
arXiv, 2016 In this paper, we study a single-species population model with pulse toxicant input to a small polluted environment. The intrinsic rate of population is affected by environment and toxin in organisms. The toxin in organisms is influenced by toxin in environment and the food chain. A new mathematical model is derived.
arxiv
JCI Insight, 2023 Cephalic tetanus (CT) is a severe form of tetanus that follows head wounds and the intoxication of cranial nerves by tetanus neurotoxin (TeNT). Hallmarks of CT are cerebral palsy, which anticipates the spastic paralysis of tetanus, and rapid evolution of
Federico Fabris +10 more
doaj +1 more source
A pragmatic harm reduction approach to manage a large outbreak of wound botulism in people who inject drugs, Scotland 2015 [PDF]
, 2018 Background People who inject drugs (PWID) are at an increased risk of wound botulism, a potentially fatal acute paralytic illness. During the first 6 months of 2015, a large outbreak of wound botulism was confirmed among PWID in Scotland, which resulted ...
Amanda Weir +43 more
core +1 more source
The receptor-toxin-antibody interaction: Mathematical model and numerical simulation [PDF]
arXiv, 2012 A reaction-diffusion model of receptor-toxin-antibody (RTA) interaction is studied numerically. The protective properties of an antibody against a given toxin are evaluated for a spherical cell placed into a toxin-antibody solution. The selection of parameters for numerical simulation approximately corresponds to the practically relevant values ...
arxiv
An oligoclonal combination of human monoclonal antibodies able to neutralize tetanus toxin in vivo
Toxicon: X, 2019 The use of antibody-based therapy to treat a variety of diseases and conditions is well documented. The use of antibodies as an antidote to treat tetanus infections was one of the first examples of immunotherapy and remains the standard of care for cases
Eduardo Aliprandini +5 more
doaj
Mapping the major human T helper epitopes of tetanus toxin. The emerging picture.
Journal of Immunology, 1993 Progress on the mapping of Th epitopes of tetanus toxin (tt) has been slow due to reliance on studies of clones. In this paper, human Th cell epitopes of tt were mapped using proliferation tests on PBMC in response to synthetic peptides.
Jeanette C. Reece, H. Geysen, S. Rodda
semanticscholar +1 more source
Neurobiology of Disease, 2001 The effect of pretreatment with either tetanus toxin (in ventral hippocampus) or kainic acid (into dorsal hippocampus, with or without suppression of seizures by phenobarbital) on the subsequent development of epilepsy in rats injected with tetanus toxin
J. Mellanby, A.J. Milward
doaj