Results 121 to 130 of about 15,945 (179)
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Molecular and Cellular Biochemistry, 1974
The circular dichroic spectrum of highly purified tetanus toxin has been determined between 200–310 nm. A comparison of the ellipticity between 207–243 nm and of the rotational strengths of the major resolved bands between 200–250 nm with the corresponding values from proteins of known conformation indicates that tetanus toxin contains about 20% α ...
J P, Robinson +3 more
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The circular dichroic spectrum of highly purified tetanus toxin has been determined between 200–310 nm. A comparison of the ellipticity between 207–243 nm and of the rotational strengths of the major resolved bands between 200–250 nm with the corresponding values from proteins of known conformation indicates that tetanus toxin contains about 20% α ...
J P, Robinson +3 more
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Immunochemistry of Tetanus Toxin
European Journal of Biochemistry, 1973The tyrosyl residues of tetanus toxin can be specifically nitrated by tetranitromethane. The introduction of NO2 groups into the toxin molecule is followed by a rapid decrease in toxicity. Although tryptophyl residues are differently involved and some aggregation occurs, these two phenomena do not take any significant part in the toxicity loss.
B, Bizzini, A, Turpin, M, Raynaud
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2017
Tetanus toxin provides a reliable means of inducing recurrent spontaneous epileptic seizures in the hippocampus and neocortex. The hippocampal tetanus toxin model differs from other methods of inducing spontaneous limbic seizures in that it does not require status epilepticus, and it does not have major cell loss as an early component of the syndrome ...
Walker, Matthew C. +2 more
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Tetanus toxin provides a reliable means of inducing recurrent spontaneous epileptic seizures in the hippocampus and neocortex. The hippocampal tetanus toxin model differs from other methods of inducing spontaneous limbic seizures in that it does not require status epilepticus, and it does not have major cell loss as an early component of the syndrome ...
Walker, Matthew C. +2 more
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Tetanus toxin and spinal inhibition
Brain Research, 1968Summary Tetanus toxin blocks the synaptic inhibition of feline Renshaw cells elicited by hind paw stimulation without affecting the inhibitory action of electrophoretically administered glycine. Assuming that glycine is the transmitter at spinal inhibitory synapses, these results indicate that tetanus toxin blocks the inhibitory process by reducing ...
D R, Curtis, W C, De Groat
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Enzymatic breakdown of tetanus toxin
Biochemical and Biophysical Research Communications, 1974Abstract Treatment of tetanus toxin with papain at 55°C resulted in breakdown of the molecule to yield an atoxic fraction with a molecular weight of approximately 40 000. The highly purified material exhibited partial immunological identity with the parent toxin, showed no toxicity and elicited the formation of neutralizing antibodies against tetanus.
T, Helting, O, Zwister
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Biochimica et Biophysica Acta, 1956
Abstract The combination of multi-membrane electro-decantation and ammonium sulphate fractionation resulted in an effective purification of tetanus toxin. The most highly purified material obtained in this way contained as much as 4300–4800 Lf per mg protein nitrogen.
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Abstract The combination of multi-membrane electro-decantation and ammonium sulphate fractionation resulted in an effective purification of tetanus toxin. The most highly purified material obtained in this way contained as much as 4300–4800 Lf per mg protein nitrogen.
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Journal of Neuropathology and Experimental Neurology, 1964
When mice are acutely poisoned by either crude or purified tetanus toxin, a marked increase in number and a moderate increase in size of intramitochondrial dense granules occurs. This is most pronounced in skeletal muscle but also may be observed in brain and spinal cord.
SUMNER I. ZACKS, MICHAEL F. SHEFF
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When mice are acutely poisoned by either crude or purified tetanus toxin, a marked increase in number and a moderate increase in size of intramitochondrial dense granules occurs. This is most pronounced in skeletal muscle but also may be observed in brain and spinal cord.
SUMNER I. ZACKS, MICHAEL F. SHEFF
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Molecular Pharmacology of Botulinum Toxin and Tetanus Toxin
Annual Review of Pharmacology and Toxicology, 1986Botulinum toxin is a term that has been used to describe eight different substances designated types A, B, Cb C2, D, E, F, and G. For many years it was assumed that these eight substances acted at the neuromuscular junction to block acetylcholine release. It is now known that this assumption is not entirely correct.
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On the structure of tetanus toxin
Naunyn-Schmiedeberg's Archives of Pharmacology, 1973Previous results from the literature pertaining to the molecular state of tetanus toxin are reported. By use of disc electrophoresis, gel filtration and ultracentrifugation, it is shown in this paper that tetanus toxin is likely to be constituted of subunits.
B, Bizzini, A, Turpin, M, Raynaud
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