Results 181 to 190 of about 18,141 (217)

Immunochemistry of Tetanus Toxin

European Journal of Biochemistry, 1973
The tyrosyl residues of tetanus toxin can be specifically nitrated by tetranitromethane. The introduction of NO2 groups into the toxin molecule is followed by a rapid decrease in toxicity. Although tryptophyl residues are differently involved and some aggregation occurs, these two phenomena do not take any significant part in the toxicity loss.
B, Bizzini, A, Turpin, M, Raynaud
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Purification of tetanus toxin

Biochimica et Biophysica Acta, 1956
Abstract The combination of multi-membrane electro-decantation and ammonium sulphate fractionation resulted in an effective purification of tetanus toxin. The most highly purified material obtained in this way contained as much as 4300–4800 Lf per mg protein nitrogen.
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Tetanus toxin and spinal inhibition

Brain Research, 1968
Summary Tetanus toxin blocks the synaptic inhibition of feline Renshaw cells elicited by hind paw stimulation without affecting the inhibitory action of electrophoretically administered glycine. Assuming that glycine is the transmitter at spinal inhibitory synapses, these results indicate that tetanus toxin blocks the inhibitory process by reducing ...
D R, Curtis, W C, De Groat
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The chain composition of tetanus toxin

Biochimica et Biophysica Acta (BBA) - Protein Structure, 1973
Although tetanus toxins from cell and culture filtrate appear indistinguishable by several criteria, only the filtrate toxin can be cleaved into two chains by disulfide scission. These chains approximate molecular weights of 95,000 and 55,000. Determinations of sulfhydryl groups and total half-cystine residues for both the cell and filtrate toxins gave
C J, Craven, D J, Dawson
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On the similarity of tetanus and botulinum toxins

Naunyn-Schmiedeberg's Archives of Pharmacology, 1973
1. Botulinum toxin blocks neuromuscular transmission to the abductor superficialis muscle of the goldfish pectoral fin. Since the botulinum-paralysed muscles are still responsive to direct electrical stimulation and to carbachol it is probable that the toxin acts (at least partly) presynaptically.
J, Mellanby, P A, Thompson, N, Hampden
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Enzymatic breakdown of tetanus toxin

Biochemical and Biophysical Research Communications, 1974
Abstract Treatment of tetanus toxin with papain at 55°C resulted in breakdown of the molecule to yield an atoxic fraction with a molecular weight of approximately 40 000. The highly purified material exhibited partial immunological identity with the parent toxin, showed no toxicity and elicited the formation of neutralizing antibodies against tetanus.
T, Helting, O, Zwister
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Mode of Action of Tetanus Toxin

Nature, 1955
THOUGH the general effects produced by tetanus toxin on the nervous system have been reported by many investigators, there is still no precise evidence as to its mode of action1. Sherrington2 pointed out that tetanus toxin closely resembles strychnine in many of its effects, and postulated that both substances convert synaptic inhibition into ...
V B, BROOKS, D R, CURTIS, J C, ECCLES
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On the similarity of tetanus and cholera toxins

Naunyn-Schmiedeberg's Archives of Pharmacology, 1973
There are several similarities between tetanus and cholera toxins, including their ability to react with ganglioside. However, tetanus toxin reacts mostly with certain gangliosides containing sialidase-sensitive bonds, whereas cholera toxin reacts only with one particular ganglioside that does not contain any sialidase-sensitive bonds.
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The flocculation of tetanus toxin and toxoid. I

Antonie van Leeuwenhoek, 1954
1. The flocculation of tetanus toxins and toxoids produced in a modified Tarozzi broth was made the subject of an exhaustive study. 2. At least three flocculation zones were found. 3. The lowest flocculation value always proved to agree with the true point of equivalence of the antitoxin-binding (A.B.V.). 4.
J D, VAN RAMSHORST, H, RIJKS
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Molecular Pharmacology of Botulinum Toxin and Tetanus Toxin

Annual Review of Pharmacology and Toxicology, 1986
Botulinum toxin is a term that has been used to describe eight different substances designated types A, B, Cb C2, D, E, F, and G. For many years it was assumed that these eight substances acted at the neuromuscular junction to block acetylcholine release. It is now known that this assumption is not entirely correct.
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