Results 281 to 290 of about 328,500 (323)
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2017
Tetanus toxin provides a reliable means of inducing recurrent spontaneous epileptic seizures in the hippocampus and neocortex. The hippocampal tetanus toxin model differs from other methods of inducing spontaneous limbic seizures in that it does not require status epilepticus, and it does not have major cell loss as an early component of the syndrome ...
Walker, Matthew C. +2 more
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Tetanus toxin provides a reliable means of inducing recurrent spontaneous epileptic seizures in the hippocampus and neocortex. The hippocampal tetanus toxin model differs from other methods of inducing spontaneous limbic seizures in that it does not require status epilepticus, and it does not have major cell loss as an early component of the syndrome ...
Walker, Matthew C. +2 more
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On the similarity of tetanus and botulinum toxins
Naunyn-Schmiedeberg's Archives of Pharmacology, 19731. Botulinum toxin blocks neuromuscular transmission to the abductor superficialis muscle of the goldfish pectoral fin. Since the botulinum-paralysed muscles are still responsive to direct electrical stimulation and to carbachol it is probable that the toxin acts (at least partly) presynaptically.
Nicola Hampden +2 more
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The chain composition of tetanus toxin
Biochimica et Biophysica Acta (BBA) - Protein Structure, 1973Although tetanus toxins from cell and culture filtrate appear indistinguishable by several criteria, only the filtrate toxin can be cleaved into two chains by disulfide scission. These chains approximate molecular weights of 95,000 and 55,000. Determinations of sulfhydryl groups and total half-cystine residues for both the cell and filtrate toxins gave
Cyril J. Craven, Desmond J. Dawson
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Biochimica et Biophysica Acta, 1956
Abstract The combination of multi-membrane electro-decantation and ammonium sulphate fractionation resulted in an effective purification of tetanus toxin. The most highly purified material obtained in this way contained as much as 4300–4800 Lf per mg protein nitrogen.
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Abstract The combination of multi-membrane electro-decantation and ammonium sulphate fractionation resulted in an effective purification of tetanus toxin. The most highly purified material obtained in this way contained as much as 4300–4800 Lf per mg protein nitrogen.
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Mode of Action of Tetanus Toxin [PDF]
Nature, 1955 THOUGH the general effects produced by tetanus toxin on the nervous system have been reported by many investigators, there is still no precise evidence as to its mode of action1. Sherrington2 pointed out that tetanus toxin closely resembles strychnine in many of its effects, and postulated that both substances convert synaptic inhibition into ...
V. B. Brooks +2 more
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Tetanus toxin and spinal inhibition
Brain Research, 1968Summary Tetanus toxin blocks the synaptic inhibition of feline Renshaw cells elicited by hind paw stimulation without affecting the inhibitory action of electrophoretically administered glycine. Assuming that glycine is the transmitter at spinal inhibitory synapses, these results indicate that tetanus toxin blocks the inhibitory process by reducing ...
David R. Curtis, W. C. De Groat
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Analysis of the immune response to papain digestion products of tetanus toxin.
Acta pathologica, microbiologica, et immunologica Scandinavica. Section C, Immunology, 2009Tetanus toxin was degraded by papain and the previously characterized Fragment B and Fragment C were isolated. The induction of protective immunity against tetanus toxin was subsequently investigated in two animal models using Fragment B and Fragment C ...
T. Helting, H. H. Nau
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Molecular basis for tetanus toxin coreceptor interactions.
Biochemistry, 2008Tetanus toxin (TeNT) elicits spastic paralysis through the cleavage of vesicle-associated membrane protein-2 (VAMP-2) in neurons at the interneuronal junction of the central nervous system.
Chen Chen, M. R. Baldwin, J. Barbieri
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International Immunology, 2007
Tetanus toxoid is a routine positive control antigen for cellular assays. Previous studies identified multiple tetanus toxin (TT) epitopes, including some 'universal' epitopes.
E. James +5 more
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Tetanus toxoid is a routine positive control antigen for cellular assays. Previous studies identified multiple tetanus toxin (TT) epitopes, including some 'universal' epitopes.
E. James +5 more
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Enzymatic breakdown of tetanus toxin
Biochemical and Biophysical Research Communications, 1974Abstract Treatment of tetanus toxin with papain at 55°C resulted in breakdown of the molecule to yield an atoxic fraction with a molecular weight of approximately 40 000. The highly purified material exhibited partial immunological identity with the parent toxin, showed no toxicity and elicited the formation of neutralizing antibodies against tetanus.
Oswald Zwisler, Torsten Helting
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