Results 211 to 220 of about 7,006 (230)

Tetherin Antagonism by Primate Lentiviral Nef Proteins

Current HIV Research, 2011
The multifunctional Nef protein of primate lentiviruses is commonly considered an early viral factor that down-modulates various receptors from the cell surface and modulates several signaling pathways to facilitate viral immune evasion and to render the cell conducive for viral replication. However, Nef also acts during the late stages of infection, e.
Daniel, Sauter, Frank, Kirchhoff
openaire   +2 more sources

Transmembrane Interactions of HIV-1 Vpu and Tetherin

Current HIV Research, 2012
Tetherin is a type II membrane protein that bears a N-terminal transmembrane domain, an extracellular coiled-coil structure and a C-terminal GPI anchor. This unique topology allows tetherin to block the release of a wide range of enveloped viruses from the cell surface.
Fei, Guo, Chen, Liang
openaire   +2 more sources

The Antiviral Activities of Tetherin

2013
Tetherin (BST2/CD317) has emerged as a key host cell defense molecule, inhibiting the release and spread of diverse enveloped virions from infected cells. In this chapter, I review the molecular and cellular basis for tetherin's antiviral activities and the function of virally encoded countermeasures that disrupt its function. I further describe recent
openaire   +3 more sources

BST-2/Tetherin is involved in BAFF-enhanced proliferation and survival via canonical NF-κB signaling in neoplastic B-lymphoid cells.

Experimental Cell Research, 2020
The development of Sjögren's syndrome (SS) is accompanied by B cell hyperproliferation and mutation. Our previous study identified aberrant expression of BST-2 (also known as Tetherin/CD317) in B cells from either the peripheral blood or infiltrated ...
Jiayao Fu, Huan Shi, Tianle Zhan, Hui Li, L. Ye, Lisong Xie, Zhi-jun Wang, Bao-L Wang, Lingyan Zheng   +8 more
semanticscholar   +1 more source

Unique Evolution of Antiviral Tetherin in Bats

2022
(Uploaded by Plazi for the Bat Literature Project) Bats are recognized as important reservoirs of viruses deadly to other mammals, including humans. These infections are typically nonpathogenic in bats, raising questions about host response differences that might exist between bats and other mammals.
Hayward, Joshua A., Tachedjian, Mary, Johnson, Adam, Irving, Aaron T., Gordon, Tamsin B., Cui, Jie, Nicolas, Alexis, Smith, Ina, Boyd, Victoria, Marsh, Glenn A., Baker, Michelle L., Wang, Lin-Fa, Tachedjian, Gilda, Lowen, Anice C.   +13 more
openaire   +1 more source

Tetherin/BST-2: Restriction Factor or Immunomodulator?

Current HIV Research, 2016
Cell-mediated immune (CMI) responses are critical for the control of HIV-1 infection and their importance was highlighted by the existence of viral proteins, particularly Vpu and Nef, that antagonize these responses. Pandemic HIV-1 Vpu counteracts Tetherin/BST-2, a host factor that could prevent the release of HIV-1 virions by tethering virions on the ...
Sam X, Li, Bradley S, Barrett, Kejun, Guo, Mario L, Santiago   +3 more
openaire   +2 more sources

Tetherin signaling

Nature Immunology, 2014
openaire   +1 more source

Neither ritonavir nor darunavir affect cell surface expression of tetherin or Vpu-mediated tetherin down-modulation

AIDS, 2010
Björn D, Kuhl, Richard D, Sloan, Daniel A, Donahue, Tamara, Bar-Magen, Chen, Liang, Mark A, Wainberg   +5 more
openaire   +2 more sources

Generation and initial characterization of in vivo knockout of tetherin/BST2 in chicken

bioRxiv
Lenka Ungrová, P. Trefil, Jiří Plachý, J. Mucksová, J. Kalina, M. Reinišová, Sonja Härtle, Eliška Gáliková, Dana Kučerová, Veronika Krchlíková, V. Pečenka, V. Karafiát, J. Hejnar, D. Elleder   +13 more
semanticscholar   +1 more source

Tetherin Inhibits HIV-1 Release by Directly Tethering Virions to Cells

Cell, 2009
Marc C Johnson, Paul D Bieniasz, Devon A Gregory   +2 more
exaly