Results 51 to 60 of about 90,627 (259)

Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus

FEBS Open Bio, EarlyView.
BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima, Gustavo Narvaes Guimarães, Emilyane de Oliveira Santana Amaral, Bianca Caroline Figueiredo Bianco, Manuel Jara‐Espejo, Sérgio Roberto Peres Line, Ana Paula de Souza, Aline Cristiane Planello   +7 more
wiley   +1 more source

A dominant negative mitofusin causes mitochondrial perinuclear clusters because of aberrant tethering

Life Science Alliance, 2023
Our analysis of a CMT2A-associated mitofusin variant reveals that aberrant mitochondrial tethering results in perinuclear clusters and that conformational dynamics in Hinge 2 are required to progress from membrane tethering to membrane fusion.
Stephanie R Sloat, Suzanne Hoppins
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Clinical Variability and Genotype Driven Outcomes in an International Cohort of 14 Pediatric FIG4 Patients

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Biallelic FIG4 variants classically cause distinct conditions characterized by peripheral neuropathy (Charcot‐Marie‐Tooth disease type 4J) or skeletal dysplasia (Yunis‐Varón syndrome). However, central nervous system involvement is increasingly recognized. The prevalence and specific characteristics of movement disorders within FIG4‐
Andrea Gangfuß, Vykuntaraju K. Gowda, Daniel Natera‐de Benito, Pinki Munot, Maria Vanegas, Alejandra Darling, Constanze Reutlinger, Laura Carrera‐Garcia, Gilbert Wunderlich, Heike Kölbel, Burkhard Stüve, David Muhmann, Lucía Monfort Belenguer, Diana‐Gabriela Barca, Viveka Santhosh Reddy C, Varunvenkat M. Srinivasan, Cristina Molina Anguita, Heinz Jungbluth, Hormos Salimi Dafsari, Thomas Rossor, Johann Böhm, Ulrike Schara‐Schmidt, Andreas Roos   +22 more
wiley   +1 more source

Enhancing the nutritional value of preserved rice straw with calcite-based minerals for cattle in volcanic eruption-affected areas

Journal of the Indonesian Tropical Animal Agriculture
The December 2023 Mount Marapi eruption likely disrupted the mineral balance in tethered cattle by altering soil and forage composition. This study examined (1) mineral imbalances in tethered cattle and (2) the effectiveness of calcite-based mineral ...
K. Khalil, D. Anata, H. Hermon, H. Hendri, J. Achmadi   +4 more
doaj   +1 more source

Membrane-anchored human Rab GTPases directly mediate membrane tethering in vitro

Biology Open, 2014
Rab GTPases are master regulators of eukaryotic endomembrane systems, particularly functioning in membrane tethering to confer the directionality of intracellular membrane trafficking.
Naoki Tamura, Joji Mima
doaj   +1 more source

An active tethering mechanism controls the fate of vesicles

Nature Communications, 2021
Molecular tethers physically bridge transport vesicles to their target membranes as a prerequisite step for fusion. Here the authors control vesicle tethering using optogenetic approaches to study the interplay between vesicle tethering and fusion.
Seong J. An, Felix Rivera-Molina, Alexander Anneken, Zhiqun Xi, Brian McNellis, Vladimir I. Polejaev, Derek Toomre   +6 more
doaj   +1 more source

Importance of anterior leaflet tethering in predicting recurrence of ischemic mitral regurgitation after restrictive annuloplasty

, 2012
ObjectiveWe investigated the relationship between anterior mitral leaflet (AML) tethering and recurrent ischemic mitral regurgitation (MR) after restrictive annuloplasty. We also explored whether the effect of AML tethering was secondary to modifications
Pieluigi Stefàno, Gelsomino, Sandro, Fabiana Lucà, van Garsse, Leen, Carmelo Massimiliano Rao, Jos Maessen, Maessen, Jos; id_orcid, Lorusso, Roberto, Leen van Garsse, Sandro Gelsomino, Rao, Carmelo Massimiliano, Roberto Lorusso, Luca, Fabiana, Stefano, Pieluigi, Gelsomino, S., Stefano, P.   +15 more
core   +1 more source

DNA‐Templated 2D Heterostructures as Phototriggered Dynamic Nanohybrids: From Releasing Molecular Loads to Controlling Enzyme Biocatalytic Function

Advanced Functional Materials, EarlyView.
DNA strands are employed both as dynamic linkers and nanoscale templates for the integration of Ag2S nanoparticles on MoS2, which in turn imparted photothermal responsiveness; this feature permits the selective cargo (fluorophore, quantum dots or an enzyme) release from the MoS2 surface in response to local heat induced by light irradiation.
Kai Chen, Haosen Miao, Weiying Hong, Matteo Palma   +3 more
wiley   +1 more source

Mobile tethering: Overview, perspectives and challengess

, 2014
Purpose: The purpose of this paper is to analyze mobile tethering from technological and social perspectives. Mobile tethering allows us to share cellular data connection with others over WiFi, Bluetooth or USB.
Durmus, Yunus, Bouwman, Harry, Constantinescu, Mihai, Onur, Ertan, de Reuver, Mark, Nikou, Shahrokh, Djurica, Miodrag, Glatz, Philipp Maria   +7 more
core   +2 more sources