Membrane Tethering Potency of Rab-Family Small GTPases Is Defined by the C-Terminal Hypervariable Regions [PDF]
Frontiers in Cell and Developmental Biology, 2020 Membrane tethering is a crucial step to determine the spatiotemporal specificity of secretory and endocytic trafficking pathways in all eukaryotic endomembrane systems.
Sanae Ueda, Naoki Tamura, Joji Mima
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Membrane tethering complexes in the endosomal system [PDF]
Frontiers in Cell and Developmental Biology, 2016 Vesicles that are generated by endocytic events at the plasma membrane are destined to early endosomes. A prerequisite for proper fusion is the tethering of two membrane entities. Tethering of vesicles to early endosomes is mediated by the CORVET complex,
Anne eSpang
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C9orf72-catalyzed GTP loading of Rab39A enables HOPS-mediated membrane tethering and fusion in mammalian autophagy [PDF]
Nature Communications, 2023 The multi-subunit homotypic fusion and vacuole protein sorting (HOPS) membrane-tethering complex is required for autophagosome-lysosome fusion in mammals, yet reconstituting the mammalian HOPS complex remains a challenge.
Shen Zhang +13 more
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The Tricalbin-Family Endoplasmic Reticulum-Plasma Membrane Tethering Proteins Attenuate ROS-Involved Caspofungin Sensitivity in Candida albicans [PDF]
Microbiology Spectrum, 2022 The endoplasmic reticulum-plasma membrane (ER-PM) contacts are one kind of important membrane contact structures in eukaryotic cells, which mediate material and message exchange between the ER and the PM.
Li Yang +3 more
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Tethering of Multi-Vesicular Bodies and the Tonoplast to the Plasma Membrane in Plants
Frontiers in Plant Science, 2019 Tethering of the plasma membrane (PM) and many organelles to the endoplasmic reticulum (ER) for communication and lipid exchange has been widely reported. However, despite growing interest in multi-vesicular bodies (MVBs) as possible sources of exosomes,
Kai Tao +7 more
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Manipulating Endoplasmic Reticulum-Plasma Membrane Tethering in Plants Through Fluorescent Protein Complementation [PDF]
Frontiers in Plant Science, 2019 The bimolecular fluorescence complementation (BiFC) assay has been widely used to examine interactions between integral and peripheral proteins within putative plasma membrane (PM) microdomains.
Kai Tao +6 more
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The Endoplasmic Reticulum–Plasma Membrane Tethering Protein Ice2 Controls Lipid Droplet Size via the Regulation of Phosphatidylcholine in Candida albicans [PDF]
Journal of FungiLipid droplets (LDs) are intracellular organelles that play important roles in cellular lipid metabolism; they change their sizes and numbers in response to both intracellular and extracellular signals.
Ying Deng +6 more
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Positive-Sense RNA Viruses Reprogramming Membrane Contact Sites to Remodel Organelles and Control Cell Fate [PDF]
VirusesEukaryotic cells rely on a highly coordinated organelle network to maintain metabolism, signaling, stress adaptation and cell survival. Membrane contact sites (MCSs) provide essential platforms for inter-organelle communication. As obligate intracellular
Duo Zhang +5 more
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Reconstitution of Membrane Tethering Mediated by Rab-Family Small GTPases [PDF]
Biophysical Reviews, 2018 Joji Mima
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The Small GTPase Arf6 Functions as a Membrane Tether in a Chemically-Defined Reconstitution System
Frontiers in Cell and Developmental Biology, 2021 Arf-family small GTPases are essential protein components for membrane trafficking in all eukaryotic endomembrane systems, particularly during the formation of membrane-bound, coat protein complex-coated transport carriers.
Kana Fujibayashi, Joji Mima
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