Results 1 to 10 of about 18,593 (112)
Frontiers in Microbiology, 2015 Rab GTPases are the key regulators of intracellular membrane trafficking in eukaryotes. Many viruses and intracellular bacterial pathogens have evolved to hijack the host Rab GTPase functions, mainly through activators and effector proteins, for their ...
Kiran Kondabagil
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GP73 is a TBC-domain Rab GTPase-activating protein contributing to the pathogenesis of non-alcoholic fatty liver disease without obesity [PDF]
Nature Communications, 2021 Dysregulation of lipid metabolism and transport contribute to the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Here the authors identify GP73 as a TBC-domain Rab GTPase-activating protein that regulates very low-density lipoprotein export ...
Yumeng Peng +32 more
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Rab GTPase Mediating Regulation of NALP3 in Colorectal Cancer [PDF]
Molecules, 2020 The NALP3 inflammasome signaling contributes to inflammation within tumor tissues. This inflammation may be promoted by the vesicle trafficking of inflammasome components and cytokines. Rab5, Rab7 and Rab11 regulate vesicle trafficking. However, the role
Gülçin Tezcan +5 more
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Localization of PPM1H Phosphatase Tunes Parkinson’s Disease-Linked LRRK2 Kinase-Mediated Rab GTPase Phosphorylation and Ciliogenesis [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2023 Claire Y Chiang +2 more
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Rab 25: Oncogenes and Tumor Suppressive of Cancer [PDF]
E3S Web of Conferences, 2021 Rab 25 is a small GTPase belonging to the RAS (rat sarcoma) superfamily. It is expressed in epithelial cells only and serves as a regulator of various intracellular signaling pathways.
Chen Flora
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Rab GTPases as Modulators of Vascular Function
Cells, 2022 Rab GTPases, the largest family of small GTPases, are ubiquitously expressed proteins that control various aspects of cellular function, from cell survival to exocytosis. Rabs cycle between the GDP-bound inactive form and the GTP-bound active form.
Somasundaram Raghavan +2 more
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Cell Reports, 2023 Summary: Parkinson’s disease-causing leucine-rich repeat kinase 2 (LRRK2) mutations lead to varying degrees of Rab GTPase hyperphosphorylation. Puzzlingly, LRRK2 GTPase-inactivating mutations—which do not affect intrinsic kinase activity—lead to higher ...
Capria Rinaldi +8 more
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Rab GTPase: a new mitotic delivery service. [PDF]
Frontiers in Cell and Developmental Biology, 2015 Luisa eCapalbo
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A Large Rab GTPase Family in a Small GTPase World [PDF]
Small GTPases, 2017 Jin Seok Woo +2 more
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Basolateral Endocytic Recycling Requires RAB-10 and AMPH-1 Mediated Recruitment of RAB-5 GAP TBC-2 to Endosomes. [PDF]
PLoS Genetics, 2015 The small GTPase RAB-5/Rab5 is a master regulator of the early endosome, required for a myriad of coordinated activities, including the degradation and recycling of internalized cargo.
Ou Liu, Barth D Grant
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