Diversity and plasticity in Rab GTPase nucleotide release mechanism has consequences for Rab activation and inactivation [PDF]
eLife, 2014 Ras superfamily GTPase activation and inactivation occur by canonical nucleotide exchange and GTP hydrolysis mechanisms. Despite conservation of active-site residues, the Ras-related Rab GTPase activation pathway differs from Ras and between different ...
Lars Langemeyer +5 more
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PLoS Genetics, 2018 In metazoans, apoptotic cells are swiftly engulfed by phagocytes and degraded inside phagosomes. Multiple small GTPases in the Rab family are known to function in phagosome maturation by regulating vesicle trafficking.
Ryan Haley, Ying Wang, Zheng Zhou
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TBC-8, a putative RAB-2 GAP, regulates dense core vesicle maturation in Caenorhabditis elegans. [PDF]
PLoS Genetics, 2012 Dense core vesicles (DCVs) are thought to be generated at the late Golgi apparatus as immature DCVs, which subsequently undergo a maturation process through clathrin-mediated membrane remodeling events.
Mandy Hannemann +5 more
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Phylogenetic reconstruction and evolution of the Rab GTPase gene family in Amoebozoa. [PDF]
Small GTPases, 2022 Rab GTPase is a paralog-rich gene family that controls the maintenance of the eukaryotic cell compartmentalization system. Diverse eukaryotes have varying numbers of Rab paralogs. Currently, little is known about the evolutionary pattern of Rab GTPase in
Porfírio-Sousa AL +3 more
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Consequences of Rab GTPase Dysfunction in Genetic or Acquired Human Diseases [PDF]
Small GTPases, 2018 Guangpu Li, Marcellus J Banworth
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The glyceraldehyde-3-phosphate dehydrogenase and the small GTPase Rab 2 are crucial for Brucella replication. [PDF]
PLoS Pathogens, 2009 The intracellular pathogen Brucella abortus survives and replicates inside host cells within an endoplasmic reticulum (ER)-derived replicative organelle named the "Brucella-containing vacuole" (BCV).
Emilie Fugier +7 more
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The Small GTPase Rab-35 Facilitates the Initiation of Phagosome Maturation and Acts as a Robustness Factor for Apoptotic Cell Clearance [PDF]
, 2021 We recently identified the novel function of the small GTPase RAB-35 in apoptotic cell clearance in Caenorhabditis elegans, a process in which dying cells are engulfed and degraded inside phagosomes.
Haley, Ryan, Zhou, Zheng
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α1B-adrenergic receptors differentially associate with Rab proteins during homologous and heterologous desensitization. [PDF]
PLoS ONE, 2015 Internalization of G protein-coupled receptors can be triggered by agonists or by other stimuli. The process begins within seconds of cell activation and contributes to receptor desensitization.
Jean A Castillo-Badillo +5 more
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CED-10/Rac1 regulates endocytic recycling through the RAB-5 GAP TBC-2. [PDF]
PLoS Genetics, 2012 Rac1 is a founding member of the Rho-GTPase family and a key regulator of membrane remodeling. In the context of apoptotic cell corpse engulfment, CED-10/Rac1 acts with its bipartite guanine nucleotide exchange factor, CED-5/Dock180-CED-12/ELMO, in an ...
Lin Sun +8 more
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The Regulation of Rab GTPases by Phosphorylation
Biomolecules, 2021 Rab proteins are small GTPases that act as molecular switches for intracellular vesicle trafficking. Although their function is mainly regulated by regulatory proteins such as GTPase-activating proteins and guanine nucleotide exchange factors, recent ...
Lejia Xu +4 more
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