Results 31 to 40 of about 78,155 (186)
Golgi-Resident GTPase Rab30 Promotes the Biogenesis of Pathogen-Containing Autophagosomes. [PDF]
PLoS ONE, 2016 Autophagy acts as a host-defense system against pathogenic microorganisms such as Group A Streptococcus (GAS). Autophagy is a membrane-mediated degradation system that is regulated by intracellular membrane trafficking regulators, including small GTPase ...
Seiichiro Oda +6 more
doaj +1 more source
Knockdown of Rab21 inhibits proliferation and induces apoptosis in human glioma cells
Cellular & Molecular Biology Letters, 2017 Background Gliomas are commonly malignant tumors that arise in the human central nervous system and have a low overall five-year survival rate. Previous studies reported that several members of Rab GTPase family are involved in the development of glioma,
Jian Ge +5 more
doaj +1 more source
RAB-10-Dependent Membrane Transport Is Required for Dendrite Arborization. [PDF]
PLoS Genetics, 2015 Formation of elaborately branched dendrites is necessary for the proper input and connectivity of many sensory neurons. Previous studies have revealed that dendritic growth relies heavily on ER-to-Golgi transport, Golgi outposts and endocytic recycling ...
Wei Zou +4 more
doaj +1 more source
Phytopathology Research, 2022 Small GTPases of the Rab family play important roles in membrane trafficking and autophagy. Previous studies have shown that the small GTPase Sec4 is involved in vegetative growth, protein secretion, and pathogenicity of fungal phytopathogens.
Guanbo Wang +4 more
doaj +1 more source
RAB-6.1 and RAB-6.2 Promote Retrograde Transport in C. elegans. [PDF]
PLoS ONE, 2016 Retrograde transport is a critical mechanism for recycling certain membrane cargo. Following endocytosis from the plasma membrane, retrograde cargo is moved from early endosomes to Golgi followed by transport (recycling) back to the plasma membrane.
Donglei Zhang +3 more
doaj +1 more source
Structure, regulation and cellular functions of Rab geranylgeranyl transferase and its cellular partner Rab Escort Protein [PDF]
, 2012 Rab geranylgeranyl transferase is an enzyme responsible for double geranylgeranylation of Rab proteins in all eukaryotic cells. In the present article we would like to focus on new findings concerning the holoenzyme structure and mechanism of catalytic ...
Swiezewska, Ewa, Gutkowska, Malgorzata
core +1 more source
rab-27 acts in an intestinal pathway to inhibit axon regeneration in C. elegans.
PLoS Genetics, 2021 Injured axons must regenerate to restore nervous system function, and regeneration is regulated in part by external factors from non-neuronal tissues.
Alexander T Lin-Moore +2 more
doaj +1 more source
, 2016 Correction: α-MSH Stimulates Glucose Uptake in Mouse Muscle and Phosphorylates Rab-GTPase-Activating Protein TBC1D1 Independently of ...
PLOS ONE (2189197)
core +1 more source
eLife, 2021 Rab GTPases are molecular switches that regulate membrane trafficking in all cells. Neurons have particular demands on membrane trafficking and express numerous Rab GTPases of unknown function.
Friederike E Kohrs +12 more
doaj +1 more source
Nature Communications, 2017 Ephrin receptors mediate contact inhibition, but their intracellular trafficking during this process is unknown. Here the authors show that EphA2 receptor trafficking is regulated by the Rab GTPase effector Rab-coupling protein, which associates with ...
Christine Gundry +11 more
doaj +1 more source