Results 51 to 60 of about 78,155 (186)
Advanced Science, EarlyView.A novel geometry‐resolved membrane platform provides a seamlessly integrated pipeline for studying curvature‐sensing proteins. By linking shotgun proteomics with quantitative imaging, this approach enables both the unbiased discovery and rigorous validation of novel sensors across the entire curvature range—positive, negative, and zero.
Takumi Komikawa +6 more
wiley +1 more source
Analysis of Rab GTPase and GTPase-activating protein function at primary cilia.
, 2008 Primary cilia are sensory structures on the cell surface whose formation requires tight integration of microtubules and polarized membrane trafficking events. Rabs are GTP-binding proteins of the Ras superfamily that control directed membrane trafficking
Francis A. Barr +2 more
core +1 more source
Advanced Science, EarlyView.This review systematically elaborates on the mechanisms underlying physiological regulation and pathological dysregulation of biomolecular phase separation. It also summarizes advances in phase‑separation‑targeted therapeutic strategies and the design of functional biomaterials inspired by this process.
Jiawei Zhu +5 more
wiley +1 more source
RAB-7 antagonizes LET-23 EGFR signaling during vulva development in Caenorhabditis elegans. [PDF]
PLoS ONE, 2012 The Rab7 GTPase regulates late endosome trafficking of the Epidermal Growth Factor Receptor (EGFR) to the lysosome for degradation. However, less is known about how Rab7 activity, functioning late in the endocytic pathway, affects EGFR signaling. Here we
Olga Skorobogata, Christian E Rocheleau
doaj +1 more source
Animal Models and Experimental Medicine, EarlyView.Animal models enable mechanistic testing of how ischemic injury disrupts neurovascular trafficking and drives cognitive vulnerability after stroke. Complementary models capture distinct vascular, cellular, white matter, and cognitive features of PSCI.
Pratchaya Kaewkaen
wiley +1 more source
Expression of GTPase-defective RAB-5 interferes with the trafficking of recycling cargo.
, 2012 (A and B) Confocal images of recycling cargo hTAC-GFP in the intestinal epithelium. Wild-type animals (A) and animals expressing of GTPase-defective RAB-5 (tagRFP-RAB-5(Q78L)) (B) are shown. (C) Quantification of hTAC-GFP puncta and tubule intensity.
Farhad Karbassi (152302) +8 more
core +1 more source
Plants, 2022 This investigation involved a comparative analysis of the small GTPase superfamily in S. lycopersicum super strain B compared to their analogues in leguminous and other non-leguminous species.
Hassan S. Al-Zahrani +4 more
doaj +1 more source
BMEMat, EarlyView.A defined 700 nm low‐density nanotopographical interface mechanically primes MSCs through the integrin β1–focal adhesion–Akt–Rab27a‐dependent pathway, enhancing exosome secretion and osteoinductive potency. Enrichment of miR‐548d‐5p in these exosomes promotes osteogenic differentiation and bone regeneration, establishing nanotopography‐guided MSC ...
Ziqi Zhang +12 more
wiley +1 more source
The Arabidopsis Rab GTPase family: another enigma variation.
, 2016 The Arabidopsis genome sequence reveals that gene families such as the Rab GTPase family, which encodes key determinants of vesicle-targeting specificity, are considerably more diverse in plants and mammals than in yeast.
core +1 more source
Two mechanisms regulate directional cell growth in Arabidopsis lateral roots
eLife, 2019 Morphogenesis in plants depends critically on directional (anisotropic) growth. This occurs principally perpendicular to the net orientation of cellulose microfibrils (CMFs), which is in turn controlled by cortical microtubules (CMTs).
Charlotte Kirchhelle +4 more
doaj +1 more source