Results 71 to 80 of about 78,155 (186)

Aspartic Protease Inhibition Induces Proteomic Remodeling in Paracoccidioides brasiliensis

PROTEOMICS, EarlyView.
ABSTRACT Paracoccidioidomycosis (PCM) is a major systemic mycosis in Latin America caused by Paracoccidioides brasiliensis, yet the contribution of aspartic proteases to fungal physiology and pathogenicity remains poorly understood. Here, we employed data‐independent acquisition (DIA)‐based quantitative proteomics to investigate the impact of pepstatin
Sarah Fernandes Lima, Wilson Dias Segura, Leonardo Brogliato de Moraes, Reinaldo Souza Oliveira, Pedro Henrique Corteletti Manfio, Alison Felipe Alencar Chaves, Wagner Luiz Batista   +6 more
wiley   +1 more source

Proteomic Analysis of Mixed Cell Membrane Extracts From Triple‐Negative Breast Cancer Cell Lines Revealed Broad Metabolic Reprogramming Associated With Tumor Progression

PROTEOMICS, EarlyView.
ABSTRACT Triple‐negative breast cancer (TNBC) represents the most aggressive subtype with limited therapeutic options and the poorest clinical outcomes. Using high‐resolution nUPLC‐QTOF‐MS/MS, we performed comprehensive proteomic profiling of TNBC cell lines representing disease progression stages: HCC‐1937 (stage IIB), HCC‐1599 (stage IIIA), and MDA ...
Claudia Sissely Chaviano‐Montes de Oca, Violeta Larios‐Serrato, María Luisa Labra‐Barrios, Emmanuel Ríos‐Castro, Carlos Alberto Castañón‐Sánchez, Rodolfo Moreno‐Castillo, Erika Beatriz Ángeles‐Morales, Juan Pedro Luna‐Arias   +7 more
wiley   +1 more source

Deciphering the structural diversity and regulatory layers of expanded Rab GTPases families in the parasitic protist Entamoeba histolytica

Frontiers in Chemical Biology
Rab GTPases are small GTP-binding proteins that play a central role in the regulation of vesicular traffic in all eukaryotes. Pluricellular eukaryotic organisms exhibit an increasing number of Rab GTPase-encoding genes, which may correlate with ...
Naurú Idalia Vargas-Maya, Jennifer Isabel López-Pérez, José A. Martínez-Álvarez, Ana Laura Medina-Nieto, Sairy Yarely Andrade-Guillén, Fátima Berenice Ramírez-Montiel, Ángeles Rangel-Serrano, Itzel Páramo-Pérez, Javier de la Mora, Claudia Leticia Mendoza-Macías, Felipe Padilla-Vaca, Bernardo Franco   +11 more
doaj   +1 more source

Proteomic Analysis of ARF1‐ and ARF3‐Proximal Proteins at the Trans‐Golgi Network

PROTEOMICS, EarlyView.
ABSTRACT Despite its fundamental importance, the molecular mechanisms of post‐Golgi transport remain incompletely understood. Carrier formation of post‐Golgi transport depends on ARF3 and ARF1, very close paralogs; the former localizes on the trans‐Golgi network (TGN) whereas the latter localizes on TGN and cis‐Golgi.
Taisei Uehara, Reiko Nakagawa, Takunori Satoh, Akiko K. Satoh   +3 more
wiley   +1 more source

Structural Basis of Membrane Trafficking by Rab Family Small G Protein

, 2013
The Ras-superfamily of small G proteins is a family of GTP hydrolases that is regulated by GTP/GDP binding states. One member of the Ras-superfamily, Rab, is involved in the regulation of vesicle trafficking, which is critical to endocytosis ...
Hyun Park
core   +1 more source

A proximity map of RAB GTPases delineates roles for RAB14 in EARP complex and UHRF1BP1 endosomal recruitments

Communications Biology
RAB GTPases, the most abundant small GTPase family, regulate membrane trafficking, including cargo sorting, vesicle budding, transport, docking, and fusion. Guanine exchange factors and GTPase-activating proteins control their activity.
Véronique Gaudreault, Benoit Marchand, Raphaëlle Larcher, Sonya Nassari, Francis Bourassa, Mathilde Moreau, Dominique Jean, François-Michel Boisvert, Marie A. Brunet, Steve Jean   +9 more
doaj   +1 more source

Proteo‐transcriptomic insights into the venom composition of the ectoparasitoid Eupelmus urozonus

Pest Management Science, EarlyView.
Integrated venom‐gland transcriptomics and venom proteomics of Eupelmus urozonus identified 316 venom proteins, including 75 secreted candidates, revealing diverse hydrolases, proteases/inhibitors and many uncharacterized effectors. Abstract BACKGROUND Ectoparasitoid venoms are ‘cocktails’ of bioactive molecules injected during oviposition to paralyze ...
Federica De Stefano, Carmen Scieuzo, Rosanna Salvia, Riccardo Moretti, Flora Cozzolino, Maria Monti, Heiko Vogel, Patrizia Falabella   +7 more
wiley   +1 more source

Protein LidA from Legionella is a Rab GTPase supereffector

, 2011
The causative agent of Legionnaires disease, Legionella pneumophila , injects several hundred proteins into the cell it infects, many of which interfere with or exploit vesicular transport processes.
Aymelt Itzen, Stefan Schoebel, Roger S. Goody, Adam L. Cichy, Itzen, A., Cichy, A., Schoebel, S., Goody, R., Cichy, Adam L. (author), Schoebel, Stefan (author), Itzen, Aymelt (author), Goody, Roger S. (author)   +11 more
core   +1 more source

Long non‐coding RNAs at the crossroads of inflammation, cancer and angiogenesis: Molecular mechanisms and their potential as therapeutic targets

British Journal of Pharmacology, EarlyView.
Long non‐coding RNAs (lncRNAs), a broad class of non‐protein‐coding RNAs, are characterized as new regulators of gene expression at the epigenetic, transcriptional, and post‐transcriptional level. Thus, lncRNAs are involved in the regulation of physiological processes and the development of human diseases and cancer by modulating proinflammatory ...
Charlie Leboff, Pamela Calle‐Mendoza, Maria Hatziapostolou, Christos Polytarchou   +3 more
wiley   +1 more source

Rab GTPase signaling in neurite outgrowth and axon specification [PDF]

, 2016
© 2016 Wiley Periodicals, Inc. Neurons are highly polarized cells that contain specialized subcellular domains involved in information transmission in the nervous system.
Villarroel Campos, David Leonardo, Bronfman, Francisca, González Billault, Christian, Villarroel Campos, David, Bronfman C., Francisca   +4 more
core   +1 more source