Results 81 to 90 of about 78,155 (186)
Nature Communications, 2017 Various stages of tissue morphogenesis involve the contraction of epithelial surfaces. Here, the authors identify the Rab GTPase Rab35 as an essential component of this contractile process, which functions as a membrane ratchet to ensure unidirectional ...
Cayla E. Jewett +6 more
doaj +1 more source
Cell Proliferation, EarlyView.This review systematically elucidates how primary tumours remotely drive multicellular reprogramming to construct the pre‐metastatic niche and dictate disseminated tumour cell fate. By mapping this dynamic ecosystem, we identify actionable therapeutic vulnerabilities, advocating a paradigm shift from traditional cytotoxicity toward microenvironment ...
Shengqian Wang +14 more
wiley +1 more source
Rab GTPase Protein Expression Changes in alpha-Synucleinopathy and Tauopathy Disorders
, 2020 Objective: Determine Rab GTPase expression changes in α-synucleinopathy and tauopathy disorders. Background: Alterations in Rab GTPase function are increasingly implicated in neurodegenerative diseases.
Parmar, Mayur S +4 more
core +1 more source
Endosomal Rab cycles regulate Parkin-mediated mitophagy
eLife, 2018 Damaged mitochondria are selectively eliminated by mitophagy. Parkin and PINK1, gene products mutated in familial Parkinson’s disease, play essential roles in mitophagy through ubiquitination of mitochondria.
Koji Yamano +11 more
doaj +1 more source
RNF13 regulates the endolysosomal pathway through interaction with the small GTPase Arl8B
The FEBS Journal, EarlyView.The E3 ubiquitin ligase RNF13 functions as a regulatory scaffold, organizing Arl8B‐dependent complexes and tuning downstream signaling that controls endolysosomal organization and trafficking. In this model, wild‐type RNF13 associates with Arl8B on endolysosomes, whereas Arl8B (E22D/F55A) or RNF13 (L244A) variants weaken complex assembly, potentially ...
Audrey M. Sénécal +4 more
wiley +1 more source
Characterization of selected RAB GTPase activating protein (RAB GAP) of Arabidopsis thaliana [PDF]
, 2016 8 ABSTRACT Rab GTPases (Rabs) are the most populous branch of eukaryotic Ras GTPase superfamily. In active GTP-binding conformation, they serve as key instruments in defining transient membrane identity and through various effectors regulate formation ...
Metlička, Jáchym
core
RAB-A2a dependent membrane traffic in Arabidopsis thaliana [PDF]
, 2016 Rab GTPases are major regulatory proteins of vesicle traffic and thus responsible for membrane identity, vesicle targeting and vesicle fusion. The angiosperm Rab GTPase family is grouped into eight clades (Rab-A to Rab-H) that are broadly conserved in ...
core +1 more source
Rab11 in Disease Progression [PDF]
International Journal of Molecular and Cellular Medicine, 2015 Membrane/ protein trafficking in the secretory/ biosynthetic and endocytic pathways is mediated by vesicles. Vesicle trafficking in eukaryotes is regulated by a class of small monomeric GTPases the Rab protein family.
Tanmay Bhuin, Jagat K Roy
doaj
Periodontal Medicine Rewired: Mechanisms Linking Periodontitis to Systemic Diseases
Journal of Periodontal Research, EarlyView.This review reorganizes decades of research in periodontal medicine into a multi‐dimensional framework, illustrating how periodontitis influences systemic health through at least seven interconnected mechanisms. ABSTRACT Periodontitis is now recognized not merely as a localized oral condition but as a systemic disease linked to over 70 communicable and
Mario Romandini +3 more
wiley +1 more source
Mutant Rab24 GTPase is targeted to nuclear inclusions
BMC Cell Biology, 2002 Background Members of the Rab GTPase family regulate intracellular protein trafficking, but the specific function of Rab24 remains unknown. Several attributes distinguish this protein from other members of the Rab family, including a low intrinsic GTPase
Gunning William +4 more
doaj +1 more source