Results 11 to 20 of about 47,795 (200)

Reconstitution of Autophagic-Like Membrane Tethering Reveals That Atg11 Can Bind and Cluster Vesicles on Cargo Mimetics [PDF]

Autophagy
Devika Andhare, Michael J Ragusa
exaly   +2 more sources

Human Rab Small GTPase– and Class V Myosin–Mediated Membrane Tethering in a Chemically Defined Reconstitution System [PDF]

Journal of Biological Chemistry, 2017
Joji Mima
exaly   +2 more sources

A dominant negative mitofusin causes mitochondrial perinuclear clusters because of aberrant tethering

Life Science Alliance, 2023
Our analysis of a CMT2A-associated mitofusin variant reveals that aberrant mitochondrial tethering results in perinuclear clusters and that conformational dynamics in Hinge 2 are required to progress from membrane tethering to membrane fusion.
Stephanie R Sloat, Suzanne Hoppins
doaj   +1 more source

Secretory Vesicles Targeted to Plasma Membrane During Pollen Germination and Tube Growth

Frontiers in Cell and Developmental Biology, 2021
Pollen germination and pollen tube growth are important biological events in the sexual reproduction of higher plants, during which a large number of vesicle trafficking and membrane fusion events occur.
Huaqiang Ruan, Jiang Li, Ting Wang, Haiyun Ren   +3 more
doaj   +1 more source

Docking and stability defects in mitofusin highlight the proteasome as a potential therapeutic target

iScience, 2023
Summary: Defects in mitochondrial fusion are at the base of many diseases. Mitofusins power membrane-remodeling events via self-interaction and GTP hydrolysis.
Ira Buntenbroich, Vincent Anton, Daniel Perez-Hernandez, Tânia Simões, Felix Gaedke, Astrid Schauss, Gunnar Dittmar, Jan Riemer, Mafalda Escobar-Henriques   +8 more
doaj   +1 more source

The Molecular Determinants of Mitochondrial Membrane Contact With ER, Lysosomes and Peroxisomes in Neuronal Physiology and Pathology

Frontiers in Cellular Neuroscience, 2020
Membrane tethering is an important communication method for membrane-packaged organelles. Mitochondria are organelles with a bilayer membrane, and the membrane contact between mitochondria and other organelles is indispensable for maintaining cellular ...
Yajin Liao, Yuan Dong, Jinbo Cheng
doaj   +1 more source

Membrane-anchored human Rab GTPases directly mediate membrane tethering in vitro

Biology Open, 2014
Rab GTPases are master regulators of eukaryotic endomembrane systems, particularly functioning in membrane tethering to confer the directionality of intracellular membrane trafficking.
Naoki Tamura, Joji Mima
doaj   +1 more source

Loosening ER–Mitochondria Coupling by the Expression of the Presenilin 2 Loop Domain

Cells, 2021
Presenilin 2 (PS2), one of the three proteins in which mutations are linked to familial Alzheimer’s disease (FAD), exerts different functions within the cell independently of being part of the γ-secretase complex, thus unrelated to toxic amyloid peptide ...
Michela Rossini, Paloma García-Casas, Riccardo Filadi, Paola Pizzo   +3 more
doaj   +1 more source

Structure of the HOPS tethering complex, a lysosomal membrane fusion machinery

eLife, 2022
Lysosomes are essential for cellular recycling, nutrient signaling, autophagy, and pathogenic bacteria and viruses invasion. Lysosomal fusion is fundamental to cell survival and requires HOPS, a conserved heterohexameric tethering complex.
Dmitry Shvarev, Jannis Schoppe, Caroline König, Angela Perz, Nadia Füllbrunn, Stephan Kiontke, Lars Langemeyer, Dovile Januliene, Kilian Schnelle, Daniel Kümmel, Florian Fröhlich, Arne Moeller, Christian Ungermann   +12 more
doaj   +1 more source

Tethering complexes in the Arabidopsis endomembrane system

Frontiers in Cell and Developmental Biology, 2016
Targeting of endomembrane transport containers is of the utmost importance for proper land plant growth and development. Given the immobility of plant cells, localized membrane vesicle secretion and recycling are amongst the main processes guiding proper
Nemanja eVukasinovic, Viktor eZarsky
doaj   +1 more source