Results 181 to 190 of about 139,661 (236)

Review Article: Classic Bismuth Quadruple Therapy for Helicobacter pylori Infection—Questions Focused on Clinical Practice

Alimentary Pharmacology &Therapeutics, EarlyView.
BQT remains the most effective, safe, and practical regimen for H. pylori eradication, ensuring high cure rates across diverse resistance patterns and clinical settings. ABSTRACT Background Classic bismuth quadruple therapy (BQT)—the combination of a proton pump inhibitor, bismuth, tetracycline, and metronidazole—is a standard regimen for treating ...
Javier P. Gisbert, Pablo Parra, Olga P. Nyssen   +2 more
wiley   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

A PK/PD study on antihyperalgesia by an α2/3‐GABAA receptor PAM in mice: Lack of tolerance liability and potential involvement of γ1‐GABAA receptors

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose GABAA receptors (GABAARs) are heteropentameric ion channels that control almost all CNS functions, including spinal nociception. Most GABAARs contain a γ2 subunit but differ in their α and β subunit composition. TPA023B is an α2/α3 subtype selective, non‐sedative, positive allosteric modulator (PAM) with antihyperalgesic
Elena Neumann, Mariana O. Popa, Karen T. Elvers, Misa Oyama, Daniel Ulrich, Marcus Hanley, Gui Jie Feng, Thomas Hathaway, William T. Ralvenius, Thomas Grampp, Dietmar Benke, John R. Atack, Hanns Ulrich Zeilhofer   +12 more
wiley   +1 more source

Novel Histopathologic Features of Diffuse Blue‐Gray Hyperpigmentation Associated With Kratom Use: A Case Report and Literature Review

Journal of Cutaneous Pathology, EarlyView.
ABSTRACT Background Drug‐induced hyperpigmentation accounts for 10%–20% of acquired pigmentary disorders and can be misdiagnosed for other causes such as melasma, post inflammatory changes, or heavy metal deposition. Kratom (Mitragyna speciosa), a Southeast Asian plant with an opioid‐like profile, has been increasingly used in the United States for ...
Rita Kamoua, Kristen Paradine, Craig A. Rohan, Mary McDaniel, Diane Perkins   +4 more
wiley   +1 more source

Economic burden of hidradenitis suppurativa based on healthcare resource utilization: German claims data analysis

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Background and Objectives Hidradenitis suppurativa (HS) is a chronic, debilitating skin disease affecting approximately 0.1% of the German population. Patients with HS require substantial healthcare resource utilization. This study aimed to assess the economic burden associated with HS in Germany.
Falk G. Bechara, Tanja Tran, Sandeep Kiri, Romy Bley, Kathrin Schlüter, Claudia Grellmann, Sima Melnik, Sylke Schneider‐Burrus   +7 more
wiley   +1 more source

Accuracy and reliability of a continuous glucose monitoring system with a focus on hypoglycaemia

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Aims Glucose monitoring is increasingly based on continuous glucose monitoring (CGM) systems. However, data on the accuracy of CGM within the hypoglycaemic range is sparse. This study investigated CGM accuracy within the hypoglycaemic range in three different clinical settings of hypoglycaemia.
Lukas van Baal, Lorenz Raess, Annie Mathew, Harald Lahner, Nicole Unger, Dagmar Fuhrer   +5 more
wiley   +1 more source

Risk of acute pancreatitis with DPP‐4 inhibitors versus SGLT2 inhibitors in medication‐naïve individuals with diabetes: A target trial emulation

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Aims We investigated whether dipeptidyl peptidase‐4 inhibitor (DPP‐4i) use was associated with a higher risk of acute pancreatitis compared with sodium–glucose cotransporter 2 inhibitor (SGLT2i) use in antidiabetic medication‐naïve individuals.
Takashi Tatewaki, Akira Okada, Yuya Kimura, Hideo Yasunaga   +3 more
wiley   +1 more source

Beauveria Bassiana Triggers Soybean Systemic Resistance and Causes Sublethal Effects in Spodoptera frugiperda

Entomologia Experimentalis et Applicata, EarlyView.
The interaction of soybean plant and the endophytic microorganism Beauveria bassiana was evaluated by inoculating a single trifoliate leaf. The effects of this inoculation on the herbivory, larval development, and life traits of Spodoptera frugiperda were measured.
Carla Mariane Marassatto, Lucia Pires Ferreira, Joel da Cruz Couceiro, Marta Rodrigues de Oliveira, Aline Sartori Guidolin, Italo Delalibera Jr.   +5 more
wiley   +1 more source

Reduced Fecundity Associated with Wolbachia Infection in a Neotropical Drosophilid Redução da fecundidade associada à infecção por Wolbachia em um Drosofilídeo Neotropical

Ecological Entomology, EarlyView.
Using multiple infected and uninfected Drosophila sturtevanti lines, we investigated (i) the impact of Wolbachia on fecundity and (ii) its effects relative to antibiotic treatment. Based on over 1680 dissected ovaries, fecundity was similar between infected and uninfected flies.
Letícia Carlesso de Paula Sena, Marina Magalhães Moreira, Luísa de Paula Bouzada Dias, Jhonny José Magalhães Guedes, Karla Suemy Clemente Yotoko   +4 more
wiley   +1 more source

Use of a 3D‐printed custom‐designed tracheostomy tube to stabilise a permanent tracheostoma in a 25‐year‐old Icelandic mare

Equine Veterinary Education, EarlyView.
Summary A 25‐year‐old Icelandic mare diagnosed with bilateral temporohyoid‐osteoarthropathy, moderate pharyngeal instability and bilateral laryngeal paralysis was presented because of intermittent stridor and dyspnoea worsening during exercise. As a previous ceratohyoidectomy had not improved these symptoms substantially, a permanent tracheostomy was ...
D. C. Debald, J. P. Schramel, E. Haltmayer, N. M. Biermann   +3 more
wiley   +1 more source