Results 211 to 220 of about 161,489 (263)
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Obstetrics and Gynecology Clinics of North America, 1992
The tetracyclines are inexpensive drugs that are of primary value in treating nonpregnant women who have acute urethral syndrome or endocervicitis due to Chlamydia trachomatis. They are contraindicated in pregnancy because they are injurious to fetal teeth and bone.
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The tetracyclines are inexpensive drugs that are of primary value in treating nonpregnant women who have acute urethral syndrome or endocervicitis due to Chlamydia trachomatis. They are contraindicated in pregnancy because they are injurious to fetal teeth and bone.
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Journal of the American Chemical Society, 2005
We describe a convergent, enantioselective synthesis of (-)-tetracycline (1) from benzoic acid (17 steps, 1.1% yield). Benzoic acid was transformed into the AB precursor 2 in 10 steps (11% yield), as previously described, and the latter compound was activated toward Diels-Alder cycloaddition by the introduction of an alpha-phenylthio group (two steps ...
Mark G, Charest +2 more
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We describe a convergent, enantioselective synthesis of (-)-tetracycline (1) from benzoic acid (17 steps, 1.1% yield). Benzoic acid was transformed into the AB precursor 2 in 10 steps (11% yield), as previously described, and the latter compound was activated toward Diels-Alder cycloaddition by the introduction of an alpha-phenylthio group (two steps ...
Mark G, Charest +2 more
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Cellular and Molecular Life Sciences, 2009
Resistance to tetracycline emerged soon after its discovery six decades ago. Extensive clinical and non-clinical uses of this class of antibiotic over the years have combined to select for a large number of resistant determinants, collectively termed the tetracycline resistome.
Maulik, Thaker +2 more
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Resistance to tetracycline emerged soon after its discovery six decades ago. Extensive clinical and non-clinical uses of this class of antibiotic over the years have combined to select for a large number of resistant determinants, collectively termed the tetracycline resistome.
Maulik, Thaker +2 more
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Gel chromatography of tetracycline and derivatives of tetracycline
Journal of Chromatography A, 1968Abstract The elution characteristics of tetracycline (TC), anhydrotetracycline (ATC) and 4- epi -anhydrotetracycline (EATC) were studied on Sephadex gel under various conditions of pH and salt concentration. The adsorption of the compounds was strong in acid solvents but diminished as the pH was elevated.
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The history of the tetracyclines
Annals of the New York Academy of Sciences, 2011The history of the tetracyclines involves the collective contributions of thousands of dedicated researchers, scientists, clinicians, and business executives over the course of more than 60 years. Discovered as natural products from actinomycetes soil bacteria, the tetracyclines were first reported in the scientific literature in 1948.
Mark L, Nelson, Stuart B, Levy
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Oral Surgery, Oral Medicine, Oral Pathology, 1969
Abstract Tumors induced in hamsters were examined at various times following single intraperitoneal tetracycline injections. The distribution of tetracycline fluorescence in the tumor was found to vary with time in such a way as to permit the resolution of two distinct patterns, transitory and permanent.
T, Iida, E, Gassner, F S, Sayegh
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Abstract Tumors induced in hamsters were examined at various times following single intraperitoneal tetracycline injections. The distribution of tetracycline fluorescence in the tumor was found to vary with time in such a way as to permit the resolution of two distinct patterns, transitory and permanent.
T, Iida, E, Gassner, F S, Sayegh
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Neuroprotection by tetracyclines
Trends in Pharmacological Sciences, 2004The neuroprotective properties of tetracyclines have been clearly established in rodent models of acute and chronic neurodegeneration during the past few years. Recent findings have provided novel insights into the molecular and cellular mechanisms of protection of neurons and oligodendrocytes by tetracyclines.
María, Domercq, Carlos, Matute
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American Journal of Diseases of Children, 1966
THE TETRACYCLINES were used quite extensively in clinical practice for almost a decade after their introduction before a significant number of specific references to the adverse effects of these drugs began to appear in the medical literature.
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THE TETRACYCLINES were used quite extensively in clinical practice for almost a decade after their introduction before a significant number of specific references to the adverse effects of these drugs began to appear in the medical literature.
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Chloramphenicol and Tetracyclines
Medical Clinics of North America, 1987Tetracyclines have a broad range of clinical usefulness because of their broad antimicrobial spectrum of activity. For most routine gram positive and gram negative infections, alternative agents are available, but for Chlamydiae, Rickettsiae, Brucella, and Borrelia they still remain agents of choice.
E L, Francke, H C, Neu
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Tetracyclines in ophthalmology
Survey of Ophthalmology, 1985Tetracycline and its congeners demonstrate antimicrobial activity against bacteria, Chlamydiae and Toxoplasma gondii. Ophthalmologists can use these drugs to treat bacterial and chlamydial infections, and also for ocular rosacea and similar disorders.
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