Results 51 to 60 of about 162,449 (380)

Computational approaches to shed light on molecular mechanisms in biological processes [PDF]

, 2006
Computational approaches based on Molecular Dynamics simulations, Quantum Mechanical methods and 3D Quantitative Structure-Activity Relationships were employed by computational chemistry groups at the University of Milano-Bicocca to study biological ...
Bonati, L, Bruschi, M, Cosentino, U, De Gioia, L, Fantucci, PC, Moro, G, Pandini, A, Papaleo, E, Pitea, D, Saracino, GAA, Zampella, G   +10 more
core   +1 more source

Antibiotic-Resistant Bacteria, Antimicrobial Resistance Genes, and Antibiotic Residue in Food from Animal Sources: One Health Food Safety Concern

Microorganisms, 2023
Antibiotic-resistant bacteria causing foodborne serious illnesses can be found in contaminated food. Therefore, this study aimed to identify the pathogens, genes, and antimicrobial residues present in raw milk and meat.
Muhammad Usman Qamar, Aatika, Muhammad Ismail Chughtai, Hasan Ejaz, Bi Bi Zainab Mazhari, Uzma Maqbool, Awadh Alanazi, Yasir Alruwaili, Kashaf Junaid   +8 more
doaj   +1 more source

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source

Comparison of chemical clustering methods using graph- and fingerprint-based similarity measures [PDF]

, 2003
This paper compares several published methods for clustering chemical structures, using both graph- and fingerprint-based similarity measures. The clusterings from each method were compared to determine the degree of cluster overlap. Each method was also
Blankley, C.J., Raymond, J.W., Willett, P.   +2 more
core   +1 more source

Tetracycline and Lactation

The Journal of the American Dental Association, 1983
The Journal of the American Dental Association 107 (1983) 12,14-12,14.
UNIVERSITY OF FLORIDA, GAINESVILLE, FLAUNIVERSITY OF FLORIDAGAINESVILLEFLA ( host institution ), Hendeles, Leslie, Trask, Philip A.   +2 more
openaire   +4 more sources

Cis‐unsaturated sphingolipids support growth of sphingoid base‐deficient yeast but impair plasma membrane integrity

FEBS Open Bio, EarlyView.
Sphingoid base structures, the sphingolipid backbones, vary among species. We established yeast cells in which the native sphingoid base was replaced with plant‐type bases containing cis or trans double bonds. This is, to our knowledge, the first eukaryotic model mostly composed of sphingolipids containing cis‐unsaturated sphingoid base, providing a ...
Takashi Higuchi, Saki Sugihara, Yohei Ishibashi, Kono Yushi, Hazuki Yamauchi, Motohiro Tani   +5 more
wiley   +1 more source

Dual-Channel Probe of Carbon Dots Cooperating with Lanthanide Complex Employed for Simultaneously Distinguishing and Sequentially Detecting Tetracycline and Oxytetracycline

Nanomaterials, 2021
Tetracycline (TC) and oxytetracycline (OTC) are the most widely used broad-spectrum antimicrobial agents in tetracycline drugs, and their structures and properties are very similar, so it is a great challenge to distinguish and detect these two ...
Lei Jia, Zhitao Xu, Rujie Chen, Xiangzhen Chen, Jun Xu   +4 more
doaj   +1 more source

Seasonal variations in antibiotic resistance gene transport in the Almendares River, Havana, Cuba [PDF]

, 2012
Numerous studies have quantified antibiotic resistance genes (ARG) in rivers and streams around the world, and significant relationships have been shown that relate different pollutant outputs and increased local ARG levels.
Charles W Knapp, Charles W Knapp, David eWerner, David W eGraham, Emma eBowen, Lazaro eLima, Susana eOlivares-Rieumont   +6 more
core   +2 more sources

A Fast and Easily Parallelizable Biosensor Method for Measuring Extractable Tetracyclines in Soils.

Environmental Science and Technology, 2019
Quantification of extractable antibiotics in soils is important to assessing their bioavailability and mobility, and ultimately their ecotoxicological and health risks.
Zhao Ma, Juan Liu, Hui Li, Wei Zhang, Mark A. Williams, Yanzheng Gao, F. Gudda, Chao Lu, Bing Yang, Michael Gatheru Waigi   +9 more
semanticscholar   +1 more source

LIN28B Promotes Cancer Cell Dissemination and Angiogenesis

Advanced Biology, EarlyView.
Children diagnosed with high‐risk neuroblastoma have a 5‐year event‐free survival rate of less than 50% and poor outcomes after recurrence. Deregulation of the LIN28B oncogene can be addressed in these patients. Upregulation of LIN28B is shown to support the metastatic cascade.
Diana Corallo, Sara Menegazzo, Marcella Pantile, Silvia Bresolin, Carlo Zanon, Alessandro Davini, Massimiliano Mazzone, Alessandra Biffi, Sanja Aveic   +8 more
wiley   +1 more source