The Role of Tetraether Lipid Composition in the Adaptation of Thermophilic Archaea to Acidity [PDF]
Frontiers in Microbiology, 2013 Diether and tetraether lipids are fundamental components of the archaeal cell membrane. Archaea adjust the degree of tetraether lipid cyclization in order to maintain functional membranes and cellular homeostasis when confronted with pH and/or thermal ...
Eric eBoyd +4 more
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Discovery, structure and mechanism of a tetraether lipid synthase. [PDF]
Nature, 2022 Archaea synthesize isoprenoid-based ether-linked membrane lipids, which enable them to withstand extreme environmental conditions, such as high temperatures, high salinity, and low or high pH values1–5.
Lloyd CT +6 more
europepmc +7 more sources
First Isolation and Structure Elucidation of GDNT‐β‐Glu – Tetraether Lipid Fragment from Archaeal Sulfolobus Strains [PDF]
ChemistryOpen, 2021 Due to their special chemical structure, tetraether lipids (TEL) represent essential elements of archaeal membranes, providing these organisms with extraordinary properties.
Dr. Alexander Scholte +7 more
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Biological Membranes in Extreme Conditions: Simulations of Anionic Archaeal Tetraether Lipid Membranes. [PDF]
PLoS ONE, 2016 In contrast to the majority of organisms that have cells bound by di-ester phospholipids, archaeal membranes consist of di- and tetraether phospholipids.
Luis Felipe Pineda De Castro +2 more
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The Polar Lipid Fraction E from Sulfolobus acidocaldarius Can Be Used as Liposomal Drug Stabilizing Agents to Reduce the Leakage of the Antivascular Drug Combretastatin A4 Disodium Phosphate from Tetraether/Diester Hybrid Archaeosomes [PDF]
Biophysica, 2021 Liposomes have many advantages as therapeutic capsules over free drugs such as small molecule drugs and nucleic acids. Cholesterol is commonly used as a membrane stabilizing agent in liposomal drugs (e.g., mRNA-lipid nanoparticle COVID-19 vaccines ...
Varsha P. Daswani +2 more
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Engineering archaeal membrane‐spanning lipid GDGT biosynthesis in bacteria: Implications for early life membrane transformations [PDF]
mLifeEukaryotes are hypothesized to be archaeal–bacterial chimeras. Given the different chemical structures of membrane phospholipids in archaea and bacteria, transformations of membranes during eukaryogenesis that led to the bacterial‐type membranes of ...
Huahui Chen +9 more
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On physical properties of tetraether lipid membranes: effects of cyclopentane rings. [PDF]
Archaea, 2012 This paper reviews the recent findings related to the physical properties of tetraether lipid membranes, with special attention to the effects of the number, position, and configuration of cyclopentane rings on membrane properties.
Chong PL, Ayesa U, Daswani VP, Hur EC.
europepmc +5 more sources
Tetraether archaeal lipids promote long-term survival in extreme conditions. [PDF]
Mol MicrobiolThe sole unifying feature of the incredibly diverse Archaea is their isoprenoid‐based ether‐linked lipid membranes. Unique lipid membrane composition, including an abundance of membrane‐spanning tetraether lipids, impart resistance to extreme conditions.
Liman GLS +6 more
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Fusion of Bipolar Tetraether Lipid Membranes Without Enhanced Leakage of Small Molecules. [PDF]
Sci Rep, 2019 A major challenge in liposomal research is to minimize the leakage of encapsulated cargo from either uncontrolled passive permeability across the liposomal membrane or upon fusion with other membranes.
Leriche G +5 more
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Certain, but Not All, Tetraether Lipids from the Thermoacidophilic Archaeon Sulfolobus acidocaldarius Can Form Black Lipid Membranes with Remarkable Stability and Exhibiting Mthk Channel Activity with Unusually High Ca2+ Sensitivity. [PDF]
Int J Mol Sci, 2021 Bipolar tetraether lipids (BTL) have been long thought to play a critical role in allowing thermoacidophiles to thrive under extreme conditions. In the present study, we demonstrated that not all BTLs from the thermoacidophilic archaeon Sulfolobus ...
Bonanno A, Chong PL.
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