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Evaluation of tetraether lipid-based liposomal carriers for encapsulation and retention of nucleoside-based drugs [PDF]
Bioorganic and Medicinal Chemistry Letters, 2017 Although liposomal nanoparticles are one of the most versatile class of drug delivery systems, stable liposomal formulation of small neutral drug molecules still constitutes a challenge due to the low drug retention of current lipid membrane technologies.
Geoffray Leriche +2 more
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Chemistry and Physics of Lipids, 2012 Liquid chromatography-tandem mass spectrometry of membrane lipid cores from Sulfolobus species reveals isomeric forms of ring-containing isoprenoid glycerol dialkyl glycerol tetraether components not previously recognised via the use of NMR and liquid ...
H W Morgan, M Suleman, Brendan J Keely
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Geochemistry, Geophysics, Geosystems, 2011 The TEX86 (TetraEther indeX of tetraethers consisting of 86 carbon atoms) is a proxy for sea surface temperature (SST) based on the distribution of isoprenoidal glycerol dialkyl glycerol tetraether (GDGT) membrane lipids synthesized by marine pelagic ...
Johan W H Weijers +2 more
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Archaeal Tetraether Lipids: Unique Structures and Applications
Applied Biochemistry and Biotechnology, 2002The extremely stable biomolecules manufactured by organisms from extreme environments are of great scientific and engineering interest in the development of robust and stable industrial biocatalysts. Identification of molecules that impart stability under extremes will also have a profound impact on our understanding of cellular survival.
Michael J, Hanford, Tonya L, Peeples
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Oral peptide delivery by tetraether lipid liposomes
International Journal of Pharmaceutics, 2011The aim of this study is to improve of oral peptide delivery by a novel type of liposomes containing tetraether lipids (TELs) derived from archaea bacteria. Liposomes were used for the oral delivery of the somatostatin analogue octreotide. TELs were extracted from Sulfolobus acidocaldarius and subsequently purified to single compounds.
Johannes, Parmentier +3 more
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Purification and characterization of a liposomal-forming tetraether lipid fraction
Biochemical and Biophysical Research Communications, 1990Polar lipid E, PLE, a native tetraether lipid mixture from Sulfolobus acidocaldarius is shown to spontaneously form multilamellar liposomes in aqueous media. PLE lipids were isolated as a single fraction from the crude lipid extract of S. acidocaldarius on a reverse-phase column followed by TLC and methanol precipitation.
S L, Lo, E L, Chang
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Biradical Tetraether Lipids from Thermoacidophilic Archaebacteria
1988Archaebacteria are a novel class of micro-organisms, commonly encountered in exceptional ecological niches: methanogens in the absence of oxygen and in the presence of hydrogen and carbon dioxide, halophiles at high salt concentration, thermophiles at high temperature ranging from 60° to 105°. A variety of phylogenetic arguments has led some authors to
A. Gulik +3 more
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Stability and proton-permeability of liposomes composed of archaeal tetraether lipids
Biochimica et Biophysica Acta (BBA) - Biomembranes, 1994Liposomes composed of tetraether lipids originating from the thermoacidophilic archaeon Sulfolobus acidocaldarius were analyzed for their stability and proton permeability from 20 degrees C up to 80 degrees C. At room temperature, these liposomes are considerably more stable and have a much lower proton permeability than liposomes composed of diester ...
Elferink, Marieke G.L. +3 more
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Calditol tetraether lipids of the archaebacterium Sulfolobus solfataricus. Biosynthetic studies.
The Biochemical journal, 1990Lipids from the archaebacterium Sulfolobus solfataricus are based on 72-membered macrocyclic tetraethers made up from two C40 diol units differently cyclized and either two glycerol moieties or one glycerol moiety and a unique branched-chain nonitol named calditol (glycerodialkylnonitol tetraethers, GDNTs). To elucidate the biosynthesis of calditol and
B Nicolaus +5 more
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Total Synthesis of Archaeal 72-Membered Macrocyclic Tetraether Lipids
The Journal of Organic Chemistry, 1998Total synthesis of archaeal 72-membered macrocyclic tetraether lipids 3a and 3b is reported. The synthesis was principally composed of preparation of the functionalized half-sized diether compounds 11 and 15 first followed by appropriate dimerization through Julia coupling and final macrocyclization of the crucial dialdehydes 23 and 31 by McMurry ...
T. Eguchi, K. Ibaragi, K. Kakinuma
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