Results 131 to 140 of about 23,011 (262)

Gene Transfer of Human Guanosine 5′-Triphosphate Cyclohydrolase I Restores Vascular Tetrahydrobiopterin Level and Endothelial Function in Low Renin Hypertension [PDF]

, 2003
Jie-Sheng Zheng, Xiang-Qun Yang, Keith J. Lookingland, Gregory D. Fink, Christian Heßlinger, Gregory Kapatos, Imre Kovesdi, Alex F. Chen   +7 more
openalex   +1 more source

Effects of Granulocyte-Colony-Stimulating Factor in Neutropenic AIDS-Patients [PDF]

, 1992
Bogner, Johannes R., Goebel, Frank-Detlef, Heinrich, B., Kronawitter, U., Matuschke, A.   +4 more
core   +1 more source

Diagnosis of tetrahydrobiopterin deficiency using filter paper blood spots: further development of the method and 5 years experience [PDF]

, 2018
In every newborn with even mild hyperphenylalaninemia (HPA) tetrahydrobiopterin (BH4) deficiencies need to be excluded as soon as possible. Differential diagnosis is most commonly performed by analysis of urinary neopterin and biopterin.
Abu Seda, Bettina, Blau, Nenad, Hoffmann, Georg, Opladen, Thomas, Rassi, Anahita, Thöny, Beat   +5 more
core  

Tetrahydrobiopterin responsiveness in phenylketonuria: prediction with the 48-hour loading test and genotype [PDF]

, 2013
Karen Anjema, Margreet van Rijn, Floris C. Hofstede, Annet M. Bosch, Carla E. M. Hollak, M. Estela Rubio‐Gozalbo, Maaike C. de Vries, Mirian C. H. Janssen, C Boelen, Johannes G. M. Burgerhof, Nenad Blau, M Heiner-Fokkema, Francjan J. van Spronsen   +12 more
openalex   +1 more source

A Phase 1 Study to Assess the Pharmacokinetics, Food Effect, Safety, and Tolerability of Sepiapterin in Healthy Japanese and Non-Japanese Participants

Pharmaceuticals
Background: Sepiapterin is a natural precursor of tetrahydrobiopterin (BH4), a key cofactor for phenylalanine hydroxylase. It is being developed for the treatment of patients with phenylketonuria. In this study, the ethnic differences in pharmacokinetics
Lan Gao, Diksha Kaushik, Kimberly Ingalls, Neil Smith, Ronald Kong   +4 more
doaj   +1 more source

Inducible nitric oxide synthase: identification of amino acid residues essential for dimerization and binding of tetrahydrobiopterin.

, 1995
Hyong Jin Cho, Emil Martin, Q W Xie, Shigeru Sassa, C F Nathan   +4 more
openalex   +2 more sources

Hyperglycemia Adversely Modulates Endothelial Nitric Oxide Synthase during Anesthetic Preconditioning through Tetrahydrobiopterin– and Heat Shock Protein 90–mediated Mechanisms [PDF]

, 2010
Julien Amour, Anna K. Brzezinska, Zachary Jager, Corbin D. Sullivan, Dorothée Weihrauch, Jianhai Du, Nikolina Vladic, Yang Shi, David C. Warltier, Phillip F. Pratt, Judy R. Kersten   +10 more
openalex   +1 more source

IMP dehydrogenase inhibitors reduce intracellular tetrahydrobiopterin levels through reduction of intracellular GTP levels. Indications of the regulation of GTP cyclohydrolase I activity by restriction of GTP availability in the cells.

, 1992
Kazuyuki Hatakeyama, T. Harada, Hiroyuki Kagamiyama   +2 more
openalex   +1 more source

A computational model for analysis of uncoupled NO synthase on nitric oxide and superoxide interaction in microcirculation [PDF]

, 2007
Nitric oxide (NO) produced by endothelial cells is a key component for blood-vessel dilation. Dilation is achieved through smooth muscle relaxation as a response to NO transport.
Kavdia, Mahendra, Richardson, William
core   +2 more sources

Tetrahydrobiopterin [PDF]

, 2020
openaire   +1 more source