Results 111 to 120 of about 14,507 (223)

A Phase 1 Study to Assess the Pharmacokinetics, Food Effect, Safety, and Tolerability of Sepiapterin in Healthy Japanese and Non-Japanese Participants

Pharmaceuticals
Background: Sepiapterin is a natural precursor of tetrahydrobiopterin (BH4), a key cofactor for phenylalanine hydroxylase. It is being developed for the treatment of patients with phenylketonuria. In this study, the ethnic differences in pharmacokinetics
Lan Gao, Diksha Kaushik, Kimberly Ingalls, Neil Smith, Ronald Kong   +4 more
doaj   +1 more source

Nitric oxide (NO) traffic in endothelial NO synthase. Evidence for a new NO binding site dependent on tetrahydrobiopterin?

, 2002
International audienceNitric oxide (NO) traffic within the reduced ferrous-nitrosyl complex of endothelial nitric-oxide synthase (eNOS) has been studied by ultrafast time-resolved absorption spectroscopy.
Berka, V., Vos, Marten, H., Slama-Schwok, Anny, Tsai, Ah-Lim, Négrerie, Michel, Lambry, Jean-Christophe, Martin, Jean-Louis, Vos, Marten,   +7 more
core   +1 more source

The Effects of Some Neurotoxins on Tetrahydrobiopterin Metabolism [PDF]

Previous studies in man have shown that following dosing with L--3,4-dihydroxyphenylalanine (L-DOPA) and cotrimoxazole, plasma biopterins were raised.
Edwards, Paul
core   +1 more source

Biosynthesis of tetrahydrobiopterin : purification and characterization of 6-pyruvoyl-tetrahydropterin synthase from human liver

, 1986
6-Pyruvoyl-tetrahydropterin synthase, which catalyzes the first step in the conversion of 7,8-dihydroneopterin triphosphate to tetrahydrobiopterin, was purified approximately 140,000-fold to apparent homogeneity from human liver.
Hans-Christoph CURTIUS, Redweik, Udo, Udo REDWEIK, Walter LEIMBACHER, Curtius, Hans-Christoph, Leimbacher, Walter, Sandro GHISLA, Ghisla, Sandro, Shin-Ichiro TAKIKAWA, Takikawa, Shin-Ichiro   +9 more
core   +1 more source

Mini Review The metabolic and molecular bases of tetrahydrobiopterin-responsive phenylalanine hydroxylase deWciency [PDF]

, 2004
About two-thirds of all mild phenylketonuria (PKU) patients are tetrahydrobiopterin (BH 4 )-responsive and thus can be potentially treated with BH 4 instead of a low-phenylalanine diet.
Nenad Blau, Heidi Erlandsen
core  

Tetrahydrobiopterin [PDF]

, 2020
openaire   +1 more source

L-dopa responsive dystonia due to sepiapterin reductase deficiency, a tetrahydrobiopterin deficiency presenting without hyperphenylalaninaemia [PDF]

, 2003
Sepiapterin reductase (SPR) catalyses the last step in the biosynthesis of tetrahydrobiopterin (BH4), the essential cofactor for the aromatic amino acid hydroxylases as well as glycerol-ether monooxygenase and the three isoforms of nitric oxide ...
35th European Human Genetics Conference (ESHG), Scerri, Christian A., Felice, A. E., Farrugia, Rosienne, Soler, D., Parascandolo, Raymond   +5 more
core  

Chapter 10: Tetrahydrobiopterin: An Essential Cofactor of Nitric Oxide Synthase with an Elusive Role

, 2000
This chapter surveys the roles of pterins in biology and provides an understanding of biochemical pathways that determine tetrahydrobiopterin (BH4) levels in mammalian cells and how they are regulated.
Smith, C.L.
core  

Tetrahydrobiopterin biosynthesis : Studies with specifically labeled (2H)NAD(P)H and 2H2O and of the enzymes involved

, 1985
The biosynthesis of tetrahydrobiopterin from either dihydroneopterin triphosphate, sepiapterin, dihydrosepiapterin or dihydrobiopterin was investigated using extracts from human liver, dihydrofolate reductase and purified sepiapterin reductase from human
Heintel, Dorothee, Curtius, Hans-Christoph, Leimbacher, Walter, Niederwieser, Alois, Kuster, Thomas, Ghisla, Sandro   +5 more
core   +1 more source

Tetrahydrobiopterin and dysfunction of endothelial nitric oxide synthase in coronary arteries.

, 1995
BACKGROUND: The L-arginine/nitric oxide pathway plays a key role in the regulation of arterial tone. Biosynthesis of nitric oxide requires activation of nitric oxide synthase in the presence of tetrahydrobiopterin as a cofactor.
COSENTINO, Francesco, Katusić ZS
core