Results 91 to 100 of about 14,039 (215)

Tetrahydrobiopterin protects soluble guanylate cyclase against oxidative inactivation

Pteridines, 2013
Tetrahydrobiopterin (BH4) is a major endogenous vasoprotective agent that improves endothelial function by increasing nitric oxide (NO) synthesis and scavenging of superoxide and peroxynitrite.
Schmidt Kurt, Werner Ernst R., Mayer Bernd   +2 more
doaj   +1 more source

Molecular diagnosis of phenylketonuria: From defective protein to disease-causing gene mutation [PDF]

Journal of Medical Biochemistry, 2009
Phenylketonuria (PKU) is the most common inborn error of amino acid metabolism, with an average incidence of 1/10000 in Caucasians. PKU is caused by more than 500 mutations in the phenylalanine hydroxylase gene (PAH) which result in phenylalanine ...
Pavlović Sonja, Stojiljković Maja
doaj  

Effect of Sepiapterin, 7,8-Dihydrobiopterin, 5,6,7,8-Tetrahydrobiopterin and Xanthopterin on Cholesterol and Phospholipid Content and Phospholipid Biosynthesis in vitro

Pteridines, 1995
Incorporation of fatty acids into phospholipids has been investigated using samples of rat live tissue homogenate, Krebs-Ringer-phosphate buffer (pH = 7A) containing 0.3% albumin, farry acid mixture and glycerol.
Rudzite Vera, Jurika Edite, Baier-Bitterlich Gabriele, Wachter Helmut, Fuchs Dietmar   +4 more
doaj   +1 more source

Native and Phosphorylated Bovine Adrenal Tyrosine 3-Monooxygenase. Interactions with Tetrahydropterins and Substrate and Stability of the Formed 4a-Hydroxy-Tetrahydrobiopterin

Pteridines, 1989
The catalytic activity of tyrosine 3-monooxygenase (tyrosine hydroxylase) is dependent on a tetrahydropterin cofactor and ezyme-bound iron. The oxidation of tetrahydrobiopterin by bovine adrenal tyrosine hydroxylase was studied by high performance liquid
Haavik Jan, Andersson Kristoffer K., Flatmark Torgeir, Petersson Leif   +3 more
doaj   +1 more source

Say NO to ROS: Their Roles in Embryonic Heart Development and Pathogenesis of Congenital Heart Defects in Maternal Diabetes

Antioxidants, 2019
Congenital heart defects (CHDs) are the most prevalent and serious birth defect, occurring in 1% of all live births. Pregestational maternal diabetes is a known risk factor for the development of CHDs, elevating the risk in the child by more than four ...
Anish Engineer, Tana Saiyin, Elizabeth R. Greco, Qingping Feng   +3 more
doaj   +1 more source

Pterin Metabolism In Haemodialysis Patients

Pteridines, 1989
Patients undertaking maintenance haemodialysis may develop a variety of neurological disorders, the most serious of which is aluminium induced encephalopathy.
Altmann Paul, Sawyer Nick, Cunningham John, Marsh Frank, Hamon Chris, Blair John A.   +5 more
doaj   +1 more source

Influences of Catecholamine Contents on Tetrahydrobiopterin Metabolism

Pteridines, 1998
The influence of changes in catecholamine metabolism on tetrahydrobiopterin biosynthesis was investigated in cultured rat pheochromocytoma PC12 cells. The increase in the cellular dopamine content after treatment with the MAO-COMT inhibitor or dopamine ...
Kuzuya Hiroshi, Sakamoto Hideo, Fujita Ko   +2 more
doaj   +1 more source

Administration of tetrahydrobiopterin improves the microcirculation and outcome in an ovine model of septic shock.

, 2012
Supplementation with tetrahydrobiopterin, a nitric oxide synthase cofactor, may reduce microvascular endothelial dysfunction in severe sepsis. We studied whether tetrahydrobiopterin administration exerts beneficial effects in an ovine septic shock model ...
Su, FUHONG, Salgado, Diamantino, Vincent, Jean Louis, He, Xinrong, Taccone, Fabio, Lorent, Sophie, de Souza Barros, Dalton, De Backer, Daniel, Velissaris, Dimitrios   +8 more
core   +1 more source

Tetrahydrobiopterin, superoxide, and vascular dysfunction [PDF]

Free Radical Biology and Medicine, 2009
(6R)-5,6,7,8-Tetrahydrobiopterin (BH(4)) is an endogenously produced pterin that is found widely distributed in mammalian tissues. BH(4) works as a cofactor of aromatic amino acid hydroxylases and nitric oxide synthases. In the vasculature a deficit of BH(4) is implicated in the mechanisms of several diseases including atherosclerosis, hypertension ...
openaire   +2 more sources

Tetrahidrobiopterina e 2-metil-3-fenil-6-aminoquinoxalina: efeito no metabolismo cerebral e envolvimento em processos cognitivos [PDF]

, 2015
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Neurociências, Florianópolis, 2015.O número de pacientes acometidos por doenças neurodegenerativas crônicas vem crescendo nas últimas ...
Silva, Lucila de Bortoli da
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