Results 71 to 80 of about 14,507 (223)

Tetrahydrobiopterin synthesis and metabolism is impaired in dystrophin-deficient mdx mice and humans

, 2021
Tetrahydrobiopterin synthesis and metabolism is impaired in dystrophin-deficient mdx mice and ...
PM McCourt (14447310), JM Ervasti (14447313), P Karachunski (13421778), CW Baumann (14447190), DA Lowe (14446512), AA Larson (14447307), B Kemp (13280805), A Lindsay (13633552), J Holm (7775717)   +8 more
core  

Tetrahydrobiopterin and Endothelial Dysfunction in Cardiovascular Diseases

Pteridines, 2006
Endothelial vasodilator dysfunction is a characteristic feature of patients at risk for coronary atheroscierosis. We have reported that insulin resistance may be a pathogenic factor for endothehal dysfunction through impaired endothelial nitric oxide ...
Shinozaki Kazuya, Kashiwagi Atsunori, Masada Masahiro, Okamura Tomio   +3 more
doaj   +1 more source

Aortic valve disease: Novel animal models for advancing our understanding of the underlying mechanisms

Animal Models and Experimental Medicine, Volume 9, Issue 10, Page 1964-1981, October 2026.
Due to the complex pathophysiology of aortic valve disease (AVD) and the resulting lack of effective pharmacotherapy, existing animal models are valuable research tools, but each has its own strengths and limitations. This review systematically surveys the major AVD models, compares their induction methods, pathological features, advantages and ...
Liya Hou, Xue Liu, Wangxing Hu, Xianbao Liu, Wei Zhu   +4 more
wiley   +1 more source

Stimulation of Tetrahydrobiopterin Synthesis by Basic Fibroblast Growth Factor in Vascular Endothelial Cells

Pteridines, 2003
The purpose of this study was to examine whether basic fibroblast growth factor (bFGF) stimulates tetrahydrobiopterin (BH4) synthesis in mouse brain microvascular endothelial cells.
Shimizu Shunichi, Miyasaka Yoshiyuki, Yamamoto Shinichiro, Ishii Masakazu, Kiuchi Yuji   +4 more
doaj   +1 more source

Treatment With Tetrahydrobiopterin Improves White Matter Maturation in a Mouse Model for Prenatal Hypoxia in Congenital Heart Disease

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background Reduced oxygen delivery in congenital heart disease causes delayed brain maturation and white matter abnormalities in utero. No treatment currently exists. Tetrahydrobiopterin (BH4) is a cofactor for neuronal nitric oxide synthase.
Jennifer Romanowicz, Camille Leonetti, Zaenab Dhari, Ludmila Korotcova, Shruti D. Ramachandra, Nemanja Saric, Paul D. Morton, Shivani Bansal, Amrita Cheema, Vittorio Gallo, Richard A. Jonas, Nobuyuki Ishibashi   +11 more
doaj   +1 more source

Tetrahydrobiopterin biosynthesis as an off-target of sulfa drugs [PDF]

, 2013
The introduction of sulfa drugs for the chemotherapy of bacterial infections in 1935 revolutionized medicine. Although their mechanism of action is understood, the molecular bases for most of their side effects remain obscure.
Johnsson K, Johnsson, Kai (author), Pojer, Florence (author), Pedersen MG, Gorska, Katarzyna Irena (author), Haruki, Hirohito (author), Pedersen, Miriam Grnølund (author), Haruki H, Gorska KI, Pojer F   +9 more
core   +1 more source

Molecular and Cellular Underpinnings of Primary Hypertension: An Integrative Mechanistic Framework

Journal of Cellular Physiology, Volume 241, Issue 10, October 2026.
ABSTRACT Hypertension is a highly prevalent clinical condition and a major contributor to global cardiovascular morbidity and mortality. Despite extensive research, its complex and multifaceted pathogenesis is yet to be fully elucidated. This paper explores the updated understanding of primary hypertension as a systemic disorder rather than an isolated
Dima Nasrallah, Alaa Abdelhamid, Omar Tluli, Yaman Al‐Haneedi, Mera Abu Hussien, Ali H. Eid   +5 more
wiley   +1 more source

Kynurenine, Tetrahydrobiopterin, and Cytokine Inflammatory Biomarkers in Individuals Affected by Diabetic Neuropathic Pain

Frontiers in Neuroscience, 2020
Neuropathic pain is a common complication of diabetes with high morbidity and poor treatment outcomes. Accumulating evidence suggests the immune system is involved in the development of diabetic neuropathy, whilst neuro-immune interactions involving the ...
Ananda Staats Pires, Ananda Staats Pires, Benjamin Heng, Vanessa X. Tan, Alexandra Latini, Marc A. Russo, Marc A. Russo, Danielle M. Santarelli, Dominic Bailey, Katie Wynne, Katie Wynne, Jayden A. O’Brien, Gilles J. Guillemin, Paul J. Austin   +13 more
doaj   +1 more source

Tetrahydrobiopterin Deficiency: From Phenotype to Genotype [PDF]

, 2017
As a result of the selective screening worldwide during the last 18 years, approximately 250 patients with tetrahydrobiopterin deficiency were discovered.
Heizmann, Claus W., Blau, Nenad, Thöny, Beat, Dhondt, Jean-Louis   +3 more
core  

Tetrahydrobiopterin Metabolism in Mental Retardation [PDF]

Optimal ‘conditions for the separation and detection of pteridines by high performance liquid chromatography (HPLC) were obtained. The retention time, reproducibility relative fluorescence and minimal detection limits of various pterins under fixed ...
Morar, Chandrakant
core   +1 more source