Results 71 to 80 of about 20,824 (230)

Endothelial Cell Tetrahydrobiopterin [PDF]

Circulation Research, 2007
See related article, pages 830–838 The predilection of atherosclerosis for specific locations in the vasculature strongly suggests that the response of the arterial wall to alterations in blood flow is an important factor in vascular disease pathogenesis.
De Bono, J, Channon, K
openaire   +1 more source

Disease Burden and Pharmacological Treatment Patterns in Children and Adults With Phenylketonuria: A Real‐World Matched Cohort Study

Journal of Inherited Metabolic Disease, Volume 49, Issue 3, May 2026.
ABSTRACT Phenylketonuria (PKU) is caused by defective catabolism of phenylalanine (Phe), resulting in Phe accumulation and subsequent neurocognitive impairment. This retrospective study used a large United States claims database linked to laboratory records (6/2018–05/2023) to compare comorbidities, healthcare resource utilization, and healthcare costs
Nicola Longo, Barbara K. Burton, Shailja Vaghela, Fan Mu, Aolin Wang, Jess Smith, Emily Reichert, Ryan B. Simpson, Vanja Sikirica, Sue Perera   +9 more
wiley   +1 more source

New approaches of morfofunktional pharmacological correction of violations of cardiovascular system in experimental preeclampsia [PDF]

, 2016
Experimental Modeling ADMA-like preeclampsia administration to rats was performed by Nnitro-L-arginine methyl ester, from 14 to 20 days of pregnancy.
Gureev, V. V.
core   +2 more sources

Autophagy induction by tetrahydrobiopterin deficiency [PDF]

Autophagy, 2011
Tetrahydrobiopterin (BH₄) deficiency is a genetic disorder associated with a variety of metabolic syndromes such as phenylketonuria (PKU). In this article, the signaling pathway by which BH₄ deficiency inactivates mTORC1 leading to the activation of the autophagic pathway was studied utilizing BH₄-deficient Spr(-/-) mice generated by the knockout of ...
Kwak, SS Kwak, Sang-Su, Suk, JK Suk, Jin-Kyu, Choi, JH Choi, Ji-Hye, Yang, SK Yang, Seung-Kyung, Kim, JW Kim, Jin-Woo, Sohn, SH Sohn, Seong-Hyang, Chung, JH Chung, Jae-Hoon, Hong, YH Hong, Yong-Hee, Lee, DH Lee, Dong-Hwan, Ahn, JK Ahn, Jeong-Keun, Min, HS Min, Hye-Sun, Fu, YM Fu, Ya-Min, Meadows, GG Meadows, Gary G., Joe, CO Joe, Cheol-O   +13 more
openaire   +2 more sources

Comparative Analysis of Dietary Patterns in Children With Phenylketonuria Phenotypes and Controls: Implications for Nutritional Status

Journal of Inherited Metabolic Disease, Volume 49, Issue 3, May 2026.
ABSTRACT Individuals with phenylketonuria (PKU), caused by different variants of the phenylalanine hydroxylase gene, need to restrict their intake of phenylalanine. This study evaluated dietary patterns and physical activity levels in children with different PKU phenotypes compared to healthy controls. Eighty‐two children were recruited (22 classic PKU
Dolores Garcia‐Arenas, Aida Ormazabal, Paula Isern, Blanca Barrau‐Martinez, Arnau Gonzalez‐Rodriguez, Alba Tor‐Roca, Rafael Llorach, Jaume Campistol‐Plana, Mireia Urpi‐Sarda, Consortium PKU.cat.   +9 more
wiley   +1 more source

Long‐Term Safety and Efficacy of Pegvaliase in Japanese Adults With Phenylketonuria: Final Results of a Phase III Trial

JIMD Reports, Volume 67, Issue 3, May 2026.
ABSTRACT Phenylketonuria (PKU) is an inborn error of metabolism leading to phenylalanine (Phe) accumulation and consequent neurological, neurocognitive, and psychiatric symptoms. Pegvaliase, a pegylated recombinant phenylalanine ammonia lyase that metabolizes Phe, effectively reduced blood Phe in phase III studies in the United States. This multicenter,
Yoko Nakajima, Mika Ishige, Tetsuya Ito, Takashi Hamazaki, Mitsuhiro Kuwahara, Lawrence Lee, Haruo Shintaku   +6 more
wiley   +1 more source

Tetrahydrobiopterin and Endothelial Dysfunction in Cardiovascular Diseases

Pteridines, 2006
Endothelial vasodilator dysfunction is a characteristic feature of patients at risk for coronary atheroscierosis. We have reported that insulin resistance may be a pathogenic factor for endothehal dysfunction through impaired endothelial nitric oxide ...
Shinozaki Kazuya, Kashiwagi Atsunori, Masada Masahiro, Okamura Tomio   +3 more
doaj   +1 more source

Response of Phenylketonuria to Tetrahydrobiopterin [PDF]

The Journal of Nutrition, 2007
A favorable response, indicated by decline of blood phenylalanine (Phe) in patients with phenylketonuria (PKU), to orally administered 6-R-L-erythro-5, 6, 7, 8-tetrahydrobiopterin (BH4) has been reported in many countries following the first publication in 1999. In this review, we describe the experience in the United States with PKU patients and their
Kimberlee, Michals-Matalon, Gita, Bhatia, Flemming, Guttler, Stephen K, Tyring, Reuben, Matalon   +4 more
openaire   +2 more sources

Emerging Role of Ferroptosis in Diabetes and Associated Complications: When Metabolic Dysregulation Meets Cell Death

Cell Proliferation, Volume 59, Issue 5, May 2026.
This study identifies ferroptosis as a key driver of diabetes and its complications via iron metabolism and lipid peroxidation, elucidates organelle interactions underlying cell vulnerability, and provides insights for targeted therapies against metabolic disorders.
Zheng Wang, Ying Zhang, Yue Xu, Mengyuan Yang, Yuan Wei, Yuan Li, Tongyue Yang, Xu Wang, Chaona Yang, Qi Feng, Guolan Xing   +10 more
wiley   +1 more source

Stimulation of Tetrahydrobiopterin Synthesis by Basic Fibroblast Growth Factor in Vascular Endothelial Cells

Pteridines, 2003
The purpose of this study was to examine whether basic fibroblast growth factor (bFGF) stimulates tetrahydrobiopterin (BH4) synthesis in mouse brain microvascular endothelial cells.
Shimizu Shunichi, Miyasaka Yoshiyuki, Yamamoto Shinichiro, Ishii Masakazu, Kiuchi Yuji   +4 more
doaj   +1 more source