Results 81 to 90 of about 14,507 (223)
Early Diagnosis of 6-Pyruvoyl-tetrahydropterin Synthase Deficiency
Pteridines, 1994 6-Pyruvoyl-tetrahydropterin synthase (PTPS) deficiency, which used to be called dihydrobiopterin synthase deficiency, is the most common kind of tetrahydrobiopterin deficiency. Early treatment by administration of tetrahydrobiopterin and neurotransmitter
Shintaku Haruo
doaj +1 more source
Linoleic acid-induced endothelial activation
Journal of Lipid Research, 2004 Hypertriglyceridemia, an important risk factor of atherosclerosis, is associated with increased circulating free fatty acids. Research to date indicates that linoleic acid (LA), the major fatty acid in the American diet, may be atherogenic by activating ...
Viswanathan Saraswathi +3 more
doaj +1 more source
Aging Cell, Volume 25, Issue 10, October 2026.Mitochondrial fission‐fusion imbalance contributes to age‐related cardio‐cerebral diseases like Alzheimer's disease, Parkinson's disease, Cerebral Infarction, Arteriosclerosis, Myocardial Infarction, Cardiac valve disease, Hypertension, and Cardiomyopathy. This review summarizes its regulatory mechanisms and interventions.
Yuyao Yin, Zijian Li
wiley +1 more source
Tetrahydrobiopterin deficiencies in the Maltese population [PDF]
, 2002 A higher than usual frequency of hyperphenylalaninaemia due to tetrahydrobiopterin (BH4) deficiencies, specifically Dihydropteridine Reductase (DHPR) deficiency, is present in the Maltese population.
34th ESHG Conference +7 more
core
Pteridines, 2000 The purpose of this study was to examine whether 17β-estradiol stimulates the synthesis of tetrahydrobiopterin : BH4), which is one of the cofactors of nitric oxide (NO) synthase, in mouse brain microvascular endothelial cells. Addition of 17()-estradiol
Shiota Kazuhiro +4 more
doaj +1 more source
Tetrahydrobiopterin in phenylketonuria: Who can benefit? [PDF]
, 2020 Phenylketonuria, abbreviated PKU, is a rare inherited metabolic disease. In this disease, a building block of protein (an amino acid) called phenylalanine cannot be converted to tyrosine. This results in high phenylalanine concentrations in blood and brain. If left untreated, this especially results in severe developmental delay as well as epilepsy and
openaire +2 more sources
Coinfections Dampen the Effects of Temperature on Host–Parasite Interactions
Ecology Letters, Volume 29, Issue 10, October 2026.Temperature can drive large shifts in host–parasite interactions, but these shifts need not correspond to strong effects on coinfecting parasite interactions. Coinfection may provide a stabilizing effect on disease in a warming world—but this effect can falter when hosts are faced with multiple stressors.
I. Will +3 more
wiley +1 more source
Catalytic residues and a predicted structure of tetrahydrobiopterin-dependent alkylglycerol mono-oxygenase [PDF]
, 2012 Alkylglycerol mono-oxygenase (EC 1.14.16.5) forms a third, distinct, class among tetrahydrobiopterin-dependent enzymes in addition to aromatic amino acid hydroxylases and nitric oxide synthases.
Watschinger, Katrin +11 more
core +1 more source
, 1997 Tetrahydrobiopterin is an essential cofactor in biosynthesis of nitric oxide. The present study was designed to determine the effect of decreased intracellular tetrahydrobiopterin levels on endothelial function of isolated cerebral arteries.
S. Milstien +3 more
core +1 more source
Glucocorticoids Inhibit Tetrahydrobiopterin-Dependent Endothelial Function
, 2001 Tetrahydrobiopterin (BH4) acts as an important co-factor for endothelial nitric oxide synthase (eNOS). Glucocorticoids have been shown to inhibit expression of the rate-limiting enzyme for tetrahydrobiopterin synthesis, GTP cyclohydrolase, in other cell
Douglas G. Johns +3 more
core +1 more source