Results 81 to 90 of about 14,039 (215)
Frontiers in Neuroscience, 2020 Neuropathic pain is a common complication of diabetes with high morbidity and poor treatment outcomes. Accumulating evidence suggests the immune system is involved in the development of diabetic neuropathy, whilst neuro-immune interactions involving the ...
Ananda Staats Pires +13 more
doaj +1 more source
Food Science &Nutrition, Volume 14, Issue 8, August 2026.Temperature‐dependent phytochemical changes modulate cardioprotective responses in healthy mice. ABSTRACT Modern lifestyle and diet, characterized by low fruit and vegetable intake, contribute to the rising prevalence of diet‐related disorders, particularly cardiovascular diseases.
Vedran Balta +6 more
wiley +1 more source
Pteridines, 2000 The purpose of this study was to examine whether 17β-estradiol stimulates the synthesis of tetrahydrobiopterin : BH4), which is one of the cofactors of nitric oxide (NO) synthase, in mouse brain microvascular endothelial cells. Addition of 17()-estradiol
Shiota Kazuhiro +4 more
doaj +1 more source
Tetrahydrobiopterin in phenylketonuria: Who can benefit? [PDF]
, 2020 Phenylketonuria, abbreviated PKU, is a rare inherited metabolic disease. In this disease, a building block of protein (an amino acid) called phenylalanine cannot be converted to tyrosine. This results in high phenylalanine concentrations in blood and brain. If left untreated, this especially results in severe developmental delay as well as epilepsy and
openaire +2 more sources
Microcirculation, Volume 33, Issue 6, August 2026.ABSTRACT Objective To propose and make testable a mechanistic hypothesis for post‐exertional malaise (PEM) in a clinically distinct subset of Long COVID patients, in whom delayed exertional symptoms coexist with consistently normal macrovascular investigations.
Yiannis K. Karipidis +1 more
wiley +1 more source
Ribavirin inhibits angiogenesis by tetrahydrobiopterin depletion.
, 2007 Ribavirin is a broad-spectrum antiviral drug that is used to treat hepatitis C virus (HCV)-infected patients. The virological response after ribavirin treatment appears to be insufficient to fully explain ribavirin-induced beneficial effects ...
Michaelis, Martin +6 more
core +1 more source
, 1996 Tetrahydrobiopterin is an essential cofactor in the biosynthesis of nitric oxide, but in the presence of O2, autooxidation of tetrahydrobiopterin leads to the production of superoxide anions and the subsequent chemical inactivation of nitric oxide. As a
H. Kinoshita, Z. S. Katusic
core +1 more source
[Tetrahydrobiopterin as putative mediator in septic shock.]
, 2013 Enhanced serum levels neopterin are associated with various immune-related diseases like septic shock and vascular leakage syndrome. Tetrahydrobiopterin (THB, 100 muM) but not bioterin induces appreciable endothelium-dependent vasodilatation and enhances
Wemer J +4 more
core
Tetrahydrobiopterin Deficiency: From Phenotype to Genotype [PDF]
, 2017 As a result of the selective screening worldwide during the last 18 years, approximately 250 patients with tetrahydrobiopterin deficiency were discovered.
Heizmann, Claus W. +3 more
core
Human carbonyl and aldose reductases: new catalytic functions in tetrahydrobiopterin biosynthesis.
, 1991 New catalytic functions of human carbonyl- and aldose reductase in tetrahydrobiopterin biosynthesis are proposed. 6-Pyruvoyl tetrahydropterin, an intermediate in the biosynthesis of tetrahydrobiopterin, was converted to 6-lactoyl tetrahydropterin and 1 ...
Park YS +6 more
core +1 more source