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Tetrahydrobiopterin Metabolism
1988Tetrahydrobiopterin is the cofactor for the hydroxylation of phenylalanine, tyrosine and tryptophan and is therefore essential for the production of monoamine neurotransmitters. Neopterin, a biosynthetic precusor of tetrahydrobiopterin, and biopterin appear in urine. In normal subjects the urinary neopterin to biopterin ratio has been found to be about
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Classifying tetrahydrobiopterin responsiveness in the hyperphenylalaninaemias
Journal of Inherited Metabolic Disease, 2008SummaryBackgroundA significant percentage of patients with hyperphenylalaninaemia (HPA) due to primary deficiency of the phenylalanine hydroxylase enzyme (PAH) respond to a dose of tetrahydrobiopterin (BH4) with an increased rate of phenylalanine (Phe) disposal. The effect is exploited therapeutically, with some patients on BH4 even tolerating a normal
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TETRAHYDROBIOPTERIN METABOLISM IN DEPRESSION
The Lancet, 1984J A, Blair +8 more
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Tetrahydrobiopterin and Dopamine Release
Psychiatry and Clinical Neurosciences, 1991Y, Watanabe +9 more
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Tetrahydrobiopterin for patients with phenylketonuria
The Lancet, 2007Angel L, Pey, Aurora, Martinez
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Regulation of Tetrahydrobiopterin Biosynthesis by Shear Stress
Circulation Research, 2007Julian D Widder +2 more
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