Results 101 to 110 of about 14,507 (223)

Tetrahydrobiopterin determines vascular remodeling through enhanced endothelial cell survival and regeneration.

, 2016
BACKGROUND: Endothelial cell (EC) survival and regeneration are important determinants of the response to vascular injury that leads to neointimal hyperplasia and accelerated atherosclerosis.

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Tetrahydrobiopterin, superoxide, and vascular dysfunction [PDF]

Free Radical Biology and Medicine, 2009
(6R)-5,6,7,8-Tetrahydrobiopterin (BH(4)) is an endogenously produced pterin that is found widely distributed in mammalian tissues. BH(4) works as a cofactor of aromatic amino acid hydroxylases and nitric oxide synthases. In the vasculature a deficit of BH(4) is implicated in the mechanisms of several diseases including atherosclerosis, hypertension ...
openaire   +2 more sources

Statin Increases GTP Cyclohydrolase I mRNA and 5,6,7,8-Tetrahydrobiopterin in Vascular Endothelial Cells

Pteridines, 2006
We investigated the effects of HMG-CoA reductase inhibitors, so-called statins, on 5,6,7,8-tctrahydrobioptcrin (BH4) metabolism in human umbilical vein endothelial cells (HUVEC).
Hattori Yoshiyuki, Nakanishi Nobuo
doaj   +1 more source

The nitric oxide synthase cofactor tetrahydrobiopterin reduces allograft ischemia-reperfusion injury after lung transplantation

, 1999
Objective: Exogenous nitric oxide reduces ischemia-reperfusion injury after solid organ transplantation. Tetrahydrobiopterin, an essential cofactor for nitric oxide synthases, may restore impaired endothelium-dependent nitric oxide synthesis.
Schaffner A, Sven Hillinger, Roland Walter, Hillinger S, Stammberger U, Rudolf Speich, Weder W, Ralph A. Schmid, Walter Weder, Andreas Zollinger, Andreas Schaffner, Gabriele Schoedon, Zollinger A, Uz Stammberger, Walter R, Speich R, Schmid RA, Schoedon G   +17 more
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Immune activation and inflammation in patients with cardiovascular disease are associated with elevated phenylalanine-to-tyrosine ratios

Pteridines, 2013
Higher serum neopterin concentrations and kynurenine-to-tryptophan (Kyn/Trp) ratios are associated with increased mortality in patients with coronary artery disease (CAD). Preferentially, Th1-type cytokine interferon-γ stimulates tryptophan breakdown and
Mangge Harald, Schnedl Wolfgang J., Schröcksnadel Sebastian, Geisler Simon, Murr Christian, Fuchs Dietmar   +5 more
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Comparison of Cost Analysis in Patients with Tetrahydrobiopterin-Responsive and Non-Responsive Phenylketonuria in Turkey

Phenylketonuria is an inherited metabolic disorder that leads to neurobehavioral dysfunction. The main treatment is a low-phenylalanine diet and/or the cofactor tetrahydrobiopterin.
Tanyel Zubarioglu, Merve Karaca Sahin, Ayse Cigdem Aktuglu Zeybek, Mehmet Serif Cansever, Ertugrul Kıykım, Karaca Sahin, Merve, Kıykım, Ertugrul, Zubarioglu, Tanyel, Cansever, Mehmet Şerif, Aktuglu Zeybek, Ayşe Çiğdem   +9 more
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Maximal dietary responsiveness after tetrahydrobiopterin (BH4) in 19 phenylalanine hydroxylase deficiency patients: What super-responders can expect

Molecular Genetics and Metabolism Reports
Background: Inherited phenylalanine hydroxylase deficiency, also known as phenylketonuria (PKU), causes poor growth and neurologic deficits in the untreated state.
Jariya Upadia, Kea Crivelly, Grace Noh, Amy Cunningham, Caroline Cerminaro, Yuwen Li, Meredith Mckoin, Madeline Chenevert, Hans C. Andersson   +8 more
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6R-L-erythro-5,6,7,8-Tetrahydrobiopterin and Dopamine Release

Pteridines, 1995
We previously reported that intracerebroventricular administration of 6R-L-erythro-5,6,7,8-tetrahydrobiopterin (6R-BJL), a cofactor for aromatic amino acid hydroxylases and nitric oxide synthase, induces an increase in DOPA levels (as an index of DA ...
Miwa Soichi, Koshimura Kunio
doaj   +1 more source

Ribavirin inhibits angiogenesis by tetrahydrobiopterin depletion.

, 2007
Ribavirin is a broad-spectrum antiviral drug that is used to treat hepatitis C virus (HCV)-infected patients. The virological response after ribavirin treatment appears to be insufficient to fully explain ribavirin-induced beneficial effects ...
Michaelis, Martin, Cinatl, Jindrich, Schmidt, Helmut, Suhan, Tatyana, Doerr, Hans Wilhelm, Michaelis, U. Ruth, Mohamed, Annisuddin   +6 more
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6R-tetrahydrobiopterin treated PKU patients below 4years of age: Physical outcomes, nutrition and genotype

, 2015
Background and Aims Phenylalanine-restricted diets have proven effective in treating phenylketonuria. However, such diets have occasionally been reported to hinder normal development.
González-Lamuño, Domingo, Bueno, María A., Llarena, Marta, Couce, María L., García, María C., Lage, Sergio, Dalmau, Jaime, Ruiz, María A., Andrade, Fernando, Aldámiz-Echevarría, Luis, Blasco, Javier, González, David, Peña-Quintana, Luis, Vitoria, Isidro, Sánchez-Valverde, Felix, Ruiz, Mónica, Alcalde, Carlos, Gil, David   +17 more
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