Results 101 to 110 of about 20,824 (230)
Purine nucleotides reduce superoxide production by nitric oxide synthase in a murine sepsis model [PDF]
, 2009 Sepsis involves a systemic inflammatory response of multiple endogenous mediators, resulting in many of the injurious and sometimes fatal physiological symptoms of the disease.
BARBEIRO, D.F. +6 more
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Maintenance of cellular tetrahydrobiopterin homeostasis
BMB Reports, 2010 Tetrahydrobiopterin (BH4) is a multifunctional cofactor of aromatic amino acid hydroxylases and nitric oxide synthase (NOS) as well as an intracellular antioxidant in animals. Through regulation of NOS activity BH4 plays a pivotal role not only in a variety of normal cellular functions but also in the pathogenesis of cardiovascular and ...
Hye-Lim, Kim, Young Shik, Park
openaire +3 more sources
Pteridines, 1989 The catalytic activity of tyrosine 3-monooxygenase (tyrosine hydroxylase) is dependent on a tetrahydropterin cofactor and ezyme-bound iron. The oxidation of tetrahydrobiopterin by bovine adrenal tyrosine hydroxylase was studied by high performance liquid
Haavik Jan +3 more
doaj +1 more source
Antioxidants, 2019 Congenital heart defects (CHDs) are the most prevalent and serious birth defect, occurring in 1% of all live births. Pregestational maternal diabetes is a known risk factor for the development of CHDs, elevating the risk in the child by more than four ...
Anish Engineer +3 more
doaj +1 more source
The key role of nitric oxide in hypoxia: hypoxic vasodilation and energy supply-demand matching [PDF]
, 2013 Significance: a mismatch between energy supply and demand induces tissue hypoxia with the potential to cause cell death and organ failure. Whenever arterial oxygen concentration is reduced, increases in blood flow - 'hypoxic vasodilation' - occur in an ...
Alex Dyson +23 more
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Pterin Metabolism In Haemodialysis Patients
Pteridines, 1989 Patients undertaking maintenance haemodialysis may develop a variety of neurological disorders, the most serious of which is aluminium induced encephalopathy.
Altmann Paul +5 more
doaj +1 more source
Influences of Catecholamine Contents on Tetrahydrobiopterin Metabolism
Pteridines, 1998 The influence of changes in catecholamine metabolism on tetrahydrobiopterin biosynthesis was investigated in cultured rat pheochromocytoma PC12 cells. The increase in the cellular dopamine content after treatment with the MAO-COMT inhibitor or dopamine ...
Kuzuya Hiroshi +2 more
doaj +1 more source
Different SNP Combinations in the GCH1 Gene and Use of Labor Analgesia [PDF]
, 2010 Background: The aim of this study was to investigate if there is an association between different SNP combinations in the guanosine triphosphate cyclohydrolase (GCH1) gene and a number of pain behavior related outcomes during labor.
Fatimah Dabo +4 more
core +1 more source
Mediators of leukocyte yctivation play a role in disseminated intravascular coagulation during orthotopic liver transplantation [PDF]
, 1994 Leukocytes play an important role in the development of disseminated intravascular coagulation (DIC). In the reperfusion phase of OLT a DIC-like situation has been described and has been held responsible for the high blood loss during this phase.
Bechstein, W. O. +6 more
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The interplay between genotype, metabolic state and cofactor treatment governs phenylalanine hydroxylase function and drug response [PDF]
, 2017 The discovery of a pharmacological treatment for phenylketonuria (PKU) raised new questions about function and dysfunction of phenylalanine hydroxylase (PAH), the enzyme deficient in this disease.
Blau, Nenad +8 more
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