Results 181 to 190 of about 20,824 (230)

Amelioration of radiation-induced skin injury by tetrahydrobiopterin: preclinical study and phase II trial. [PDF]

Mol Biomed
Li K, Song B, Yin R, Zhang S.
europepmc   +1 more source

Hippo Pathway Drives Durable Non-Cell-Autonomous Ferroptosis Resistance in Lung Cancer. [PDF]

Cancer Sci
Saleh MF, Nita A, Ohta Y, Kobayashi A, Li H, Sakamoto Y, Moroishi T.   +6 more
europepmc   +1 more source

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Tetrahydrobiopterin Radical Enzymology

Chemical Reviews, 2003
AbstractFor Abstract see ChemInform Abstract in Full Text.
Chin-Chuan Wei, Brian R Crane, Dennis J Stuehr   +2 more
exaly   +3 more sources

TETRAHYDROBIOPTERIN METABOLISM IN DEPRESSION

Lancet, The, 1984
J A, Blair, P A, Barford, C, Morar, A E, Pheasant, C G, Hamon, S B, Whitburn, R J, Leeming, G P, Reynolds, A, Coppen   +8 more
exaly   +3 more sources

Tetrahydrobiopterin

Current Hypertension Reports, 2008
The endothelium plays a pivotal role in vascular physiology through a variety of factors, foremost of which is nitric oxide (NO). However, the biochemical mechanisms leading to reduced NO availability and subsequent endothelial dysfunction are not clearly understood.
Muhiddin A, Ozkor, Arshed A, Quyyumi
openaire   +2 more sources

Tetrahydrobiopterin and maternal PKU

Molecular Genetics and Metabolism, 2005
A 29-year-old woman with PKU is presented, who was successfully treated with phenylalanine restriction as well as oral BH4 during this pregnancy, with a normal outcome. Her PAH mutation was R408W/F39L. Remarkably, the blood phenylalanine control was easily accomplished during this pregnancy.
Richard, Koch, Kathryn, Moseley, Flemming, Guttler   +2 more
openaire   +2 more sources

Tetrahydrobiopterin induced neonatal tyrosinaemia

European Journal of Pediatrics, 1996
Sir: Transient neonatal tyrosinaemia is thought to be caused by late maturation of the hepatic enzymes 4-hydroxyphenylpyruvate dioxygenase and tyrosine aminotransferase [4]. In addition to prematurity, high protein intake and ascorbate deficiency are suggested as risk factors [2].
N, Blau, M, Beck, D, Matern
openaire   +2 more sources

Tetrahydrobiopterin and Parkinson's disease

Acta Neurologica Scandinavica, 1989
Two patients with Parkinson's disease were treated with 1 g tetrahydrobiopterin (BH4) for 5 days. Clinical improvement was not observed. In the cerebrospinal fluid (CSF) a 4-8 fold increase in the concentration of homovanillic acid (HVA), and a 3-fold increase in the concentration of 5-hydroxyindole acetic acid (5-HIAA) was measured.
I C, Dissing, F, Güttler, H, Pakkenberg, H, Lou, A M, Gerdes, C, Lykkelund, V, Rasmussen   +6 more
openaire   +2 more sources

Tetrahydrobiopterin: biochemistry and pathophysiology

Biochemical Journal, 2011
BH4 (6R-L-erythro-5,6,7,8-tetrahydrobiopterin) is an essential cofactor of a set of enzymes that are of central metabolic importance, including four aromatic amino acid hydroxylases, alkylglycerol mono-oxygenase and three NOS (NO synthase) isoenzymes. Consequently, BH4 is present in probably every cell or tissue of higher organisms and plays a key role
Werner, E R, Blau, N, Thöny, B
openaire   +2 more sources