Results 171 to 180 of about 14,507 (223)

Specific Potentiation of Endothelium-Dependent Contractions in SHR by Tetrahydrobiopterin

Hypertension, 2003
This study was designed to determine the effect of pteridines, R- and S-tetrahydrobiopterin, sepiapterin, and dihydrobiopterin on endothelium-dependent contractions to acetylcholine in isolated aortas from spontaneously hypertensive rat and normotensive ...
Paul Michel Georges Remi Vanhoutte, Michel Félétou, Ji Nan Zhang   +2 more
exaly   +2 more sources

Tetrahydrobiopterin and alkylglycerol monooxygenase substantially alter the murine macrophage lipidome

Proceedings of the National Academy of Sciences of the United States of America, 2015
Tetrahydrobiopterin is a cofactor synthesized from GTP with well-known roles in enzymatic nitric oxide synthesis and aromatic amino acid hydroxylation. It is used to treat mild forms of phenylketonuria. Less is known about the role of tetrahydrobiopterin
Giuseppe Astarita, Markus Ralser, Keith Channon   +2 more
exaly   +2 more sources

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Tetrahydrobiopterin

Current Hypertension Reports, 2008
The endothelium plays a pivotal role in vascular physiology through a variety of factors, foremost of which is nitric oxide (NO). However, the biochemical mechanisms leading to reduced NO availability and subsequent endothelial dysfunction are not clearly understood.
Muhiddin A, Ozkor, Arshed A, Quyyumi
openaire   +2 more sources

The auto‐oxidation of tetrahydrobiopterin

European Journal of Biochemistry, 1988
The product of the aerobic oxidation of tetrahydrobiopterin, quinonoid dihydrobiopterin, is unstable and rapidly rearranges to form a 7,8‐dihydropteridine. Kaufman [Kaufman, S. (1967) J. Biol. Chem. 242, 3934–3943] identified the stable product produced in 0.1 M phosphate pH 6.8, as 7,8‐dihydrobiopterin. However, Armarego et al. [Armarego, W. L.
M D, Davis, S, Kaufman, S, Milstien
openaire   +2 more sources

Tetrahydrobiopterin and maternal PKU

Molecular Genetics and Metabolism, 2005
A 29-year-old woman with PKU is presented, who was successfully treated with phenylalanine restriction as well as oral BH4 during this pregnancy, with a normal outcome. Her PAH mutation was R408W/F39L. Remarkably, the blood phenylalanine control was easily accomplished during this pregnancy.
Richard, Koch, Kathryn, Moseley, Flemming, Guttler   +2 more
openaire   +2 more sources

Tetrahydrobiopterin and Parkinson's disease

Acta Neurologica Scandinavica, 1989
Two patients with Parkinson's disease were treated with 1 g tetrahydrobiopterin (BH4) for 5 days. Clinical improvement was not observed. In the cerebrospinal fluid (CSF) a 4-8 fold increase in the concentration of homovanillic acid (HVA), and a 3-fold increase in the concentration of 5-hydroxyindole acetic acid (5-HIAA) was measured.
I C, Dissing, F, Güttler, H, Pakkenberg, H, Lou, A M, Gerdes, C, Lykkelund, V, Rasmussen   +6 more
openaire   +2 more sources

Tetrahydrobiopterin Radical Enzymology

Chemical Reviews, 2003
AbstractFor Abstract see ChemInform Abstract in Full Text.
Chin-Chuan, Wei, Brian R, Crane, Dennis J, Stuehr   +2 more
openaire   +2 more sources