Cell extracts of Methylobacterium extorquens AM1 were recently found to catalyze the dehydrogenation of methylene tetrahydromethanopterin (methylene H4MPT) with NAD(+) and NADP(+). The purification of a 32-kDa NADP-specific methylene H4MPT dehydrogenase (
Thauer, R. ; https://orcid.org/ +4 more
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Scheme of C1 metabolism of the methylotroph Methylobacterium extorquens AM1.
The bacterium oxidizes methanol to formaldehyde that is condensed with a tetrahydromethanopterin and further oxidized to formate. Formate reacts with tetrahydropterin and formyl-tetrahydrofolate is further converted to methylenetetrahydrofolate (part 1 ...
Georg Fuchs (361294) +2 more
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(A) Schematic depiction showing the sarcosine pathway ongoing in mitochondrion. Red rectangles highlight the amino acids, whose tissue levels were increased due to sarcosine treatment.
Marie Stiborova (2710300) +10 more
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Physical map location of the Escherichia coli gene encoding the bifunctional enzyme 5,10-methylene-tetrahydrofolate dehydrogenase/5,10-methenyl-tetrahydrofolate cyclohydrolase [PDF]
G P, Dimri +3 more
openaire +3 more sources
NADPH-Related Enzymes and Cancer: Facts and Insights Into the Application of Immunohistochemistry. [PDF]
Scudeler CM +6 more
europepmc +1 more source
Folate is required for the synthesis of nucleotides, the regeneration of methionine, and methylation reactions. The one-carbon tetrahydrofolate (THF) pathways in higher organisms are separated into the cytoplasmic and mitochondrial compartments.
Christensen, Karen E.
core
Influence of <i>MTHFD1L</i> variants on the susceptibility to hypertension in the Chinese Han population. [PDF]
Li Q +7 more
europepmc +1 more source
Glutamate potentiates susceptibility of P. aeruginosa clinical isolates to gentamycin: a new adjuvant hope for an old antibiotic. [PDF]
Nageeb WM +3 more
europepmc +1 more source
Biochemical parallels between catabolic pathways for lignin-associated aromatic dimers. [PDF]
Michener JK.
europepmc +1 more source
The critical role of methylenetetrahydrofolate dehydrogenases in immune regulation and auto-immunity. [PDF]
Bunyard P, Makrecka-Kuka M, McMillan L.
europepmc +1 more source

