Transcriptomic analysis reveals pathways underlying the multi‐antibiotic resistance of Klebsiella pneumoniae [PDF]
IET Systems BiologyKlebsiella pneumoniae, an opportunistic pathogen, is pervasively distributed across the world. Its escalating antibiotic resistance poses a serious threat to global public health. The mechanisms behind this resistance remain largely elusive.
Ying Liu +6 more
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Editorial for Special Issue "Antiprotozoal Activity of Natural Products" [PDF]
Antibiotics (Basel), 2023 Neglected tropical diseases (NTDs), a group of diverse infectious diseases, repre-sent the leading cause of morbidity and mortality among the world's low-income pop-ulations.
Cecilia Baldassarri +5 more
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Formylation of tetrahydrofolate by formyl phosphate [PDF]
FEBS Letters, 1990 Formyl phosphate is the putative intermediate in the formylation of tetrahydrofolate (THF) catalyzed by N10‐formylTHF synthetase. In this study the non‐enzymic reaction between formyl phosphate and THF was examined at 5°C. 1H‐NMR, HPLC and kinetic analysis of the proton‐catalyzed conversion of the product to N5,10‐methenylTHF were used to identify the ...
Jahansouz, Hossain +2 more
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Macrophage adaptation leads to parallel evolution of genetically diverseEscherichia colismall-colony variants with increased fitness in vivo and antibiotic collateral sensitivity [PDF]
, 2016 Small-colony variants (SCVs) are commonly observed in evolution experiments and clinical isolates, being associated with antibiotic resistance and persistent infections.
Costa, Henrique +2 more
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Efecto de la suplementación con vitaminas del complejo B sobre el declive cognitivo en pacientes con enfermedad de Alzheimer. Revisión sistemática y metanálisis [PDF]
, 2023 Introduction: Cognitive decline is a marker for the onset and progression of Alzheimer's disease (AD). Currently, modification of risk factors, such as nutrition, are promising for the treatment of AD.
Corredor, Valentina +6 more
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In Vivo Rate of Formaldehyde Condensation with Tetrahydrofolate [PDF]
Metabolites, 2020 Formaldehyde is a highly reactive compound that participates in multiple spontaneous reactions, but these are mostly deleterious and damage cellular components. In contrast, the spontaneous condensation of formaldehyde with tetrahydrofolate (THF) has been proposed to contribute to the assimilation of this intermediate during growth on C1 carbon sources
He, Hai +7 more
openaire +7 more sources
Biological Procedures Online, 2003 Tetrahydromethanopterin (H4MPT) is a tetrahydrofolate analog originally discovered in methanogenic archaea, but later found in other archaea and bacteria. The extent to which H4MPT occurs among living organisms is unknown.
Bechard Matthew E. +3 more
doaj +1 more source
Toward eradication of B-vitamin deficiencies : considerations for crop biofortification [PDF]
, 2018 'Hidden hunger' involves insufficient intake of micronutrients and is estimated to affect over two billion people on a global scale. Malnutrition of vitamins and minerals is known to cause an alarming number of casualties, even in the developed world ...
Strobbe, Simon +1 more
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MTHFD1 controls DNA methylation in Arabidopsis. [PDF]
, 2016 DNA methylation is an epigenetic mechanism that has important functions in transcriptional silencing and is associated with repressive histone methylation (H3K9me).
Bischof, Sylvain +16 more
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Mthfs is an essential gene in mice and a component of the purinosome
Frontiers in Genetics, 2011 Tetrahydrofolates (THF) are a family of cofactors that function as one-carbon donors in folate-dependent one-carbon metabolism, a metabolic network required for the de novo synthesis of purines, thymidylate, and for the remethylation of homocysteine to ...
Martha S Field +2 more
doaj +1 more source