Effect of polymorphisms in folate-related genes on in vitro methotrexate sensitivity in pediatric acute lymphoblastic leukemia [PDF]
, 2005 We studied whether common polymorphisms in genes involved in folate metabolism affect methotrexate (MTX) sensitivity. Ex vivo MTX sensitivity of lymphoblasts obtained from pediatric patients with acute lymphoblastic leukemia (ALL; n ...
Hooijberg, J.H. +7 more
core +1 more source
Integration of biomass formulations of genome-scale metabolic models with experimental data reveals universally essential cofactors in prokaryotes [PDF]
, 2017 The composition of a cell in terms of macromolecular building blocks and other organic molecules underlies the metabolic needs and capabilities of a species.
Bernard +50 more
core +2 more sources
Comparative genomic analysis of Leishmania (Viannia) peruviana and Leishmania (Viannia) braziliensis [PDF]
, 2015 BACKGROUND: The Leishmania (Viannia) braziliensis complex is responsible for most cases of New World tegumentary leishmaniasis. This complex includes two closely related species but with different geographic distribution and disease phenotypes, L.
Baldeviano, G. Christian +11 more
core +7 more sources
Méthotrexate en médecine interne: Methotrexate in Internal Medicine [PDF]
, 2021 Méthotrexate (MTX) is an immunosuppressant belonging to the class of anti-metabolites or antifolates. It is always prescribed at high dose in oncology and at low dose for the treatment of autoimmune diseases.
Alaoui, Fatima Zahra +4 more
core +2 more sources
pH plays a role in the mode of action of trimethoprim on Escherichia coli [PDF]
, 2018 Metabolomics-based approaches were applied to understand interactions of trimethoprim with Escherichia coli K-12 at sub-minimum inhibitory concentrations (MIC≈0.2, 0.03 and 0.003 mg L-1).
Allwood, JW +4 more
core +2 more sources
IBA57 recruits ISCA2 to form a [2Fe-2S] cluster-mediated complex [PDF]
, 2018 The maturation of mitochondrial iron-sulfur proteins requires a complex protein machinery. Human IBA57 protein was proposed to act in a late phase of this machinery, along with GLRX5, ISCA1, and ISCA2.
Banci, L. +4 more
core +2 more sources
Therapeutic Effect of Folate and Cobalamin in Diabetics [PDF]
, 2021 Diabetes Mellitus type 2 is a metabolic ailment. It is a condition when insulin is produced by our body but, it is not used properly by us. The number of diabetic patients is increasing in the whole world.
Qudsia, Farah, Riaz, Samreen
core +2 more sources
The Mechanism of the Condensation of Formaldehyde with Tetrahydrofolic Acid
Journal of Biological Chemistry, 1966 Abstract The bell-shaped pH rate profile for the reaction of tetrahydrofolic acid with formaldehyde to form 5,10-methylene tetrahydrofolic acid has been shown to result from a change in rate-determining step with changing acidity. In alkaline solution, the rate-determining step is the acid-catalyzed dehydration of hydroxymethyl tetrahydrofolic acid and
R G, Kallen, W P, Jencks
openaire +2 more sources
Metabolism‐Based Biomarkers for Rapid Phenotypic Antibiotic Susceptibility Testing
Advanced Science, EarlyView.Metabolic differences emerging after antibiotic exposure provide rapid phenotypic signals of susceptibility and resistance. This review summarizes metabolic biomarkers for rapid phenotypic AST, associated with nutrient uptake, respiratory activity, metabolic reprogramming, and enzymatic function. ABSTRACT The accelerating global crisis of antimicrobial
Sha Yu +7 more
wiley +1 more source
Cancer Chemotherapy and Pharmacology, 2000 To detect possible interactions between (-)-formyl-tetrahydrofolic acid (leucovorin, (-)-fTHF) and (+)-formyl-tetrahydrofolic acid ((+)-fTHF) on the plasma and intracellular pharmacokinetics following their simultaneous administration.Plasma levels of (-)-fTHF, (-)-methyl-THF, and (+)-fTHF were determined in samples from four volunteers following the ...
Schleyer, E. +6 more
openaire +3 more sources