Results 21 to 30 of about 757 (166)

Effect of chronic alcohol ingestion on hepatic folate distribution in the rat

, 1994
The mechanism by which ethanol impairs folate metabolism remains uncertain. In the present study, we used our new technique (affinity/HPLC) for folate analysis to study the effect of chronic alcohol ingestion on the content and distribution of folates in
Barak, AJ, Selhub, J, Beckenhauer, HC, Camilo, ME, Tuma, DJ, Hidiroglou, N, Nixon, PF   +6 more
core   +1 more source

Excited State Electronic Structures of 5,10-Methenyltetrahydrofolate and 5,10-Methylenetetrahydrofolate Determined by Stark Spectroscopy

, 2016
Folates are ubiquitous cofactors that participate in a wide variety of critical biological processes. 5,10-Methenyltetrahydrofolate and its photodegradation product 5,10-methylenetetrahydrofolate are both associated with the light-driven DNA repair ...
Robert J. Stanley (1748773), Raymond F. Pauszek (1748776), Goutham Kodali (1309383)   +2 more
core   +1 more source

The Mechanism of the Condensation of Formaldehyde with Tetrahydrofolic Acid

Journal of Biological Chemistry, 1966
Abstract The bell-shaped pH rate profile for the reaction of tetrahydrofolic acid with formaldehyde to form 5,10-methylene tetrahydrofolic acid has been shown to result from a change in rate-determining step with changing acidity. In alkaline solution, the rate-determining step is the acid-catalyzed dehydration of hydroxymethyl tetrahydrofolic acid and
R G, Kallen, W P, Jencks
openaire   +2 more sources

Spontaneous Non‐Catalyzed Molecular Reactions and Interactions in the Human Body: Biomedical Implications

Advanced Science, EarlyView.
ABSTRACT The human body functions as a natural reactor for a vast network of chemical and biological reactions and physical interactions among small molecules, proteins, cells, and numerous other components. These reactions/interactions are essential for maintaining normal physiological functions.
Yuhao Cai, Chao Zhao
wiley   +1 more source

Enterohepatic circulation kinetics of bile-active folate derivatives and folate homeostasis in rats

, 1995
We examined the effect of enteric infusion of 5,10-methylenetetrahydrofolate (5,10-CH2-H4PteGlu), tetrahydrofolate (H4PteGlu), 10-formyltetrahydrofolate (10-HCO-H4PteGlu), and 5-methyltetrahydrofolate (5-CH3-H4PteGlu) on concentrations of plasma 5-CH3 ...
H. C. Shin, M. Shimoda, F. Takakuwa, E. Kokue   +3 more
core   +1 more source

MTHFD1 controls DNA methylation in Arabidopsis [PDF]

, 2016
DNA methylation is an epigenetic mechanism that has important functions in transcriptional silencing and is associated with repressive histone methylation (H3K9me).
Garcia-Salinas, Carolina, Zhai, Jixian, Wirtz, Markus, Hell, Ruediger, Jacobsen, Steven E, Cokus, Shawn J, Ramos-Parra, Perla A, Smith, Danielle C, Long, Jeff A, Díaz de la Garza, Rocío I, Bischof, Sylvain, Groth, Martin, Moissiard, Guillaume, John, Amala, Hale, Christopher J, Wang, Haifeng, Feng, Suhua   +16 more
core   +1 more source

Methionine synthase supports tumour tetrahydrofolate pools

Nature Metabolism, 2021
Mammalian cells require activated folates to generate nucleotides for growth and division. The most abundant circulating folate species is 5-methyl tetrahydrofolate (5-methyl-THF), which is used to synthesize methionine from homocysteine via the cobalamin-dependent enzyme methionine synthase (MTR).
Jonathan M. Ghergurovich, Xincheng Xu, Joshua Z. Wang, Lifeng Yang, Rolf-Peter Ryseck, Lin Wang, Joshua D. Rabinowitz   +6 more
openaire   +2 more sources

Bioresponsive pseudoGlucosinolates (psGSLs) Release Isothiocyanates (ITCs) in the Presence of Nitroreductases

Chemistry – A European Journal, EarlyView.
This work introduces the concept of pseudoglucosinolates (psGSLs) and reports the synthesis and evaluation of nitroreductase‐responsive psGSLs. These compounds represent a complementary prodrug strategy to natural glucosinolates (GSLs) for the controlled release of isothiocyanates (ITCs), enabling bio‐responsive protein labeling, as demonstrated in ...
Claire C. Jimidar, Charity S. G. Ganskow, Mervic D. Kagho, Aishi Chakrabarti, Lorenz Wiese, Michael Zollo, Ulrike Beutling, Leona C. Cesar, Julia Morud, Kamila Bugaj, Mark Brönstrup, Stephan A. Sieber, Stephan M. Hacker, Philipp Klahn   +13 more
wiley   +1 more source

The presence and distribution of reduced folates in Escherichia coli dihydrofolate reductase mutants.

, 1990
Escherichia coli DNA photolyase was overproduced and purified from each of two mutant E. coli strains lacking dihydrofolate reductase. The extent of over-production in the mutants was comparable to that seen in the wild type strain.
Rajagopalan, KV, Hamm-Alvarez, Sarah F, Sancar, Aziz   +2 more
core   +1 more source

Inherited metabolic epilepsies–established diseases, new approaches

Epilepsia Open, EarlyView.
Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley   +1 more source