A Detoxification Enzyme for Apis mellifera Newly Characterized by Recombinant Expression: 10-Formyl Tetrahydrofolate Dehydrogenase [PDF]
Frontiers in Insect Science, 2022 Honeybees are important managed pollinators that perform important ecological and economic functions. In recent decades, the obligate ectoparasite Varroa destructor severely affected survival of honeybees as it either feeds on hemolymph and fat bodies or acts as a vector for viruses.
Mating, Moritz +2 more
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Three metabolic pathways replenishing the one-carbon pool collectively support growth and virulence of Listeria monocytogenes [PDF]
eLifeThe bacterium Listeria monocytogenes can grow in the cytoplasm of infected human cells, but there it relies on specific biosynthetic pathways for intracellular nutrient supply.
Sandra Freier +9 more
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The crystal structure of a bacterial, bifunctional 5, 10 methylene-tetrahydrofolate dehydrogenase/cyclohydrolase [PDF]
Protein Science, 1999 AbstractThe structure of a bifunctional 5, 10‐methylene‐tetrahydrofolate dehydrogenase/cyclohydrolase from Escherichia coli has been determined at 2.5 Å resolution in the absence of bound substrates and compared to the NADP‐bound structure of the homologous enzyme domains from a trifunctional human synthetase enzyme.
Betty W Shen
exaly +3 more sources
Sorbitol Uptake and Oxygen Transfer Shape AOX1 Promoter Induction in Formate Dehydrogenase‐Deficient Komagataella phaffii [PDF]
Microbial BiotechnologyIn Komagataella phaffii, the use of formate as an AOX1 promoter (PAOX1) inducer in combination with sorbitol, a non‐repressive carbon source, has emerged as a promising alternative to methanol‐based expression systems.
Cristina Bustos +3 more
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Engineering serine metabolism to enhance AOX1 promoter self-induction in formate dehydrogenase-deficient Komagataella phaffii [PDF]
Microbial Cell FactoriesBackground The methylotrophic yeast Komagataella phaffii is a premier host for recombinant protein (rProt) production, which traditionally relies on methanol induction of the alcohol oxidase 1 promoter (P AOX1 ).
Rocio Cozmar +2 more
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The role of tetrahydrofolate dehydrogenase in the hepatic supply of tetrahydrobiopterin in rats [PDF]
Biochemical Journal, 1976 The reduction of 7,8-dihydrobiopterin to 5,6,7,8-tetrahydrobiopterin by rat liver tetrahydrofolate dehydrogenase (5,6,7,8-tetrahydrofolate-NADP+ oxidoreductase, EC 1.5.1.3) is competitively inhibited by trimethoprim lactate (apparent Ki 0.285 muM). An apparent Michaelis constant of 43 muM for dihydrobiopterin was obtained, which is 430 times higher ...
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Biochemical and Biophysical Research Communications, 2014 Dimethylglycine dehydrogenase (DMGDH) is a mammalian mitochondrial enzyme which plays an important role in the utilization of methyl groups derived from choline. DMGDH is a flavin containing enzyme which catalyzes the oxidative demethylation of dimethylglycine in vitro with the formation of sarcosine (N-methylglycine), hydrogen peroxide and ...
Svetlana Pakhomova +2 more
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Amino acid metabolism of the thermophilic acetogen Thermacetogenium phaeum. [PDF]
PLoS ONEAnaerobic microbial degradation of the amino acids glycine and serine either occurs through enzymes of the so-called Stickland reaction or alternatively through the glycine cleavage system (GCS).
Yanlin Cai +3 more
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Pteridines, 2021 To investigate methylene tetrahydrofolate dehydrogenase 2 (MTHFD2) expression, biological function, and correlation with head and neck squamous cell carcinoma (HNSCC) patient’s prognosis.
Sun Biqiang +5 more
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Crystals, 2023 The methylenetetrahydrofolate dehydrogenase–cyclohydrolase (FolD) enzyme has a dual activity of N5,N10-methylenetetrahydrofolate dehydrogenase and cyclohydrolase.
Sehyeok Im +4 more
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