Results 1 to 10 of about 13,771 (175)

A Detoxification Enzyme for Apis mellifera Newly Characterized by Recombinant Expression: 10-Formyl Tetrahydrofolate Dehydrogenase. [PDF]

Front Insect Sci, 2022
Honeybees are important managed pollinators that perform important ecological and economic functions. In recent decades, the obligate ectoparasite Varroa destructor severely affected survival of honeybees as it either feeds on hemolymph and fat bodies or acts as a vector for viruses.
Mating M, Sharbati S, Einspanier R.
europepmc   +3 more sources

Methylene tetrahydrofolate dehydrogenase 2 (MTHFD2) is overexpressed in head and neck squamous cell carcinoma (HNSCC) and correlated with patient’s poor prognosis

Pteridines, 2021
To investigate methylene tetrahydrofolate dehydrogenase 2 (MTHFD2) expression, biological function, and correlation with head and neck squamous cell carcinoma (HNSCC) patient’s prognosis.
Biqiang Sun
exaly   +2 more sources

Sorbitol Uptake and Oxygen Transfer Shape AOX1 Promoter Induction in Formate Dehydrogenase‐Deficient Komagataella phaffii [PDF]

Microbial Biotechnology
In Komagataella phaffii, the use of formate as an AOX1 promoter (PAOX1) inducer in combination with sorbitol, a non‐repressive carbon source, has emerged as a promising alternative to methanol‐based expression systems.
Cristina Bustos, Rocio Cozmar, Julio Berrios, Patrick Fickers   +3 more
doaj   +2 more sources

Non-canonical dihydrolipoyl transacetylase promotes chemotherapy resistance via mitochondrial tetrahydrofolate signaling [PDF]

Nature Communications
Chemotherapy is often a primary treatment for cancer. However, resistance leads to therapeutic failure. Acetylation dynamics play important regulatory roles in cancer cells, but the mechanisms by which acetylation mediates therapy resistance remain ...
Jung Seok Hwang, JiHoon Kang, Jaehyun Kim, Kiyoung Eun, Sophia West, Hannah E. Bacho, Vanessa Avalos, Sydney Shuff, Dong M. Shin, Nabil F. Saba, Kelly R. Magliocca, Cheng-Kui Qu, Haian Fu, Suresh S. Ramalingam, Andrey A. Ivanov, Taro Hitosugi, Sumin Kang   +16 more
doaj   +2 more sources

Engineering serine metabolism to enhance AOX1 promoter self-induction in formate dehydrogenase-deficient Komagataella phaffii [PDF]

Microbial Cell Factories
Background The methylotrophic yeast Komagataella phaffii is a premier host for recombinant protein (rProt) production, which traditionally relies on methanol induction of the alcohol oxidase 1 promoter (P AOX1 ).
Rocio Cozmar, Julio Berrios, Patrick Fickers   +2 more
doaj   +2 more sources

The crystal structure of a bacterial, bifunctional 5, 10 methylene‐tetrahydrofolate dehydrogenase/cyclohydrolase [PDF]

Protein Science, 1999
AbstractThe structure of a bifunctional 5, 10‐methylene‐tetrahydrofolate dehydrogenase/cyclohydrolase from Escherichia coli has been determined at 2.5 Å resolution in the absence of bound substrates and compared to the NADP‐bound structure of the homologous enzyme domains from a trifunctional human synthetase enzyme.
B W, Shen, D H, Dyer, J Y, Huang, L, D'Ari, J, Rabinowitz, B L, Stoddard   +5 more
exaly   +3 more sources

The role of tetrahydrofolate dehydrogenase in the hepatic supply of tetrahydrobiopterin in rats [PDF]

Biochemical Journal, 1976
The reduction of 7,8-dihydrobiopterin to 5,6,7,8-tetrahydrobiopterin by rat liver tetrahydrofolate dehydrogenase (5,6,7,8-tetrahydrofolate-NADP+ oxidoreductase, EC 1.5.1.3) is competitively inhibited by trimethoprim lactate (apparent Ki 0.285 muM). An apparent Michaelis constant of 43 muM for dihydrobiopterin was obtained, which is 430 times higher ...
exaly   +3 more sources

Amino acid metabolism of the thermophilic acetogen Thermacetogenium phaeum. [PDF]

PLoS ONE
Anaerobic microbial degradation of the amino acids glycine and serine either occurs through enzymes of the so-called Stickland reaction or alternatively through the glycine cleavage system (GCS).
Yanlin Cai, Andreas Marquardt, David Schleheck, Nicolai Müller   +3 more
doaj   +2 more sources

Folate in demethylation: The crystal structure of the rat dimethylglycine dehydrogenase complexed with tetrahydrofolate

Biochemical and Biophysical Research Communications, 2014
Dimethylglycine dehydrogenase (DMGDH) is a mammalian mitochondrial enzyme which plays an important role in the utilization of methyl groups derived from choline. DMGDH is a flavin containing enzyme which catalyzes the oxidative demethylation of dimethylglycine in vitro with the formation of sarcosine (N-methylglycine), hydrogen peroxide and ...
Zigmund Luka, Conrad Wagner
exaly   +4 more sources

Methylene tetrahydrofolate dehydrogenase/cyclohydrolase and the synthesis of 10-CHO-THF are essential in Leishmania major. [PDF]

Mol Microbiol, 2009
Summary10‐Formyl tetrahydrofolate (10‐CHO‐THF) is a key metabolite in C1 carbon metabolism, arising through the action of formate‐tetrahydrofolate ligase (FTL) and/or 5,10‐methenyltetrahydrofolate cyclohydrolase/5,10‐methylene tetrahydrofolate dehydrogenase (DHCH).Leishmania majorpossesses singleDHCH1andFTLgenes encoding exclusively cytosolic proteins,
Murta SM, Vickers TJ, Scott DA, Beverley SM.   +3 more
europepmc   +4 more sources