Results 21 to 30 of about 155,408 (190)

Expression and Role of Methylenetetrahydrofolate Dehydrogenase 1 Like (MTHFD1L) in Bladder Cancer

Translational Oncology, 2019
Cancer cells utilize vitamin folate to fulfill their excessive demand for nucleotides and amino acids. Dihydrofolate reductase (DHFR), an enzyme involved in folate metabolism converts dihydrofolate into tetrahydrofolate, which is required for the de novo
Marie-Lisa Eich, Maria Del Carmen Rodriguez Pena, Darshan Shimoga Chandrashekar, Alcides Chaux, Sumit Agarwal, Jennifer B. Gordetsky, James E. Ferguson, Guru P. Sonpavde, George J. Netto, Sooryanarayana Varambally   +9 more
doaj   +1 more source

Glycerol dehydrogenase: Structure, specificity, and mechanism of a family III polyol dehydrogenase [PDF]

, 2001
Background: Bacillus stearothermophilus glycerol dehydrogenase (GlyDH) (glycerol:NAD+ 2-oxidoreductase, EC 1.1.1.6) catalyzes the oxidation of glycerol to dihydroxyacetone (1,3-dihydroxypropanone) with concomitant reduction of NAD+ to NADH.
Baker PJ, Sveta Sedelnikova, Taylor R, Sedelnikova S, Baker, Patrick J., Rice DW, Muir, Nicola M., Gore, Michael G., Burke J, David W. Rice, Ruzheinikov, Sergey N., Bullough, Per A., Sedelnikova, Sveta, Sergey N. Ruzheinikov, Per A. Bullough, Patrick J. Baker, Gore MG, Burke, Jacky, Michael G. Gore, Muir NM, Bullough PA, Nicola M. Muir, Rice, David W., Robert Taylor, Ruzheinikov SN, Jacky Burke, Taylor, Robert   +26 more
core   +1 more source

Remaining challenges in cellular flavin cofactor homeostasis and flavoprotein biogenesis

Frontiers in Chemistry, 2015
The primary role of the water-soluble vitamin B2 (riboflavin) in cell biology is connected with its conversion into FMN and FAD, the cofactors of a large number of dehydrogenases, oxidases and reductases involved in energetic metabolism, epigenetics ...
Teresa Anna eGiancaspero, Matilde eColella, Carmen eBrizio, Graziana eDifonzo, Giuseppina Maria eFiorino, Piero eLeone, Roderich eBrandsch, Francesco eBonomi, Stefania eIametti, Maria eBarile   +9 more
doaj   +1 more source

Cancer proteome and metabolite changes linked to SHMT2.

PLoS ONE, 2020
Serine hydroxymethyltransferase 2 (SHMT2) converts serine plus tetrahydrofolate (THF) into glycine plus methylene-THF and is upregulated at the protein level in lung and other cancers.
Jiefei Tong, Jonathan R Krieger, Paul Taylor, Rick Bagshaw, Jae Kang, Swathi Jeedigunta, Leanne E Wybenga-Groot, Wen Zhang, Heba Badr, Shideh Mirhadi, Nhu-An Pham, Étienne Coyaud, Man Yu, Ming Li, Michael Cabanero, Brian Raught, Jason T Maynes, Cynthia Hawkins, Ming Sound Tsao, Michael F Moran   +19 more
doaj   +2 more sources

One-carbon metabolizing enzyme ALDH1L1 influences mitochondrial metabolism through 5-aminoimidazole-4-carboxamide ribonucleotide accumulation and serine depletion, contributing to tumor suppression

Scientific Reports, 2023
Tumor cells generally require large amounts of nucleotides, and thus activate de novo purine synthesis (dnPS). In the dnPS reactions, 10-formyltetrahydorofolate (10-fTHF) supplied by one-carbon metabolism is utilized as a formyl group donor.
Masato Sasaki, Kazuo Yamamoto, Takeshi Ueda, Hayato Irokawa, Kouki Takeda, Ryoya Sekine, Fumie Itoh, Yutaka Tanaka, Shusuke Kuge, Nobuyuki Shibata   +9 more
doaj   +1 more source

Caracterización bioquímica de la enzima bifuncional dihidrofolato reductasa-timidilato sintasa de Leishmania (Viannia) y su evaluación como blanco molecular

Biomédica: revista del Instituto Nacional de Salud, 2013
Introducción. La dihidrofolato reductasa (DHFR) se ha utilizado como blanco molecular en tratamientos antibacterianos, anticancerígenos y antipalúdicos.
Edison Osorio, Carolina Aguilera, Nelson Naranjo, Marcel Marin, Carlos Muskus   +4 more
doaj   +1 more source

Genomic potential and physiological characteristics of C1 metabolism in novel acetogenic bacteria

Frontiers in Microbiology, 2023
Acetogenic bacteria can utilize C1 compounds, such as carbon monoxide (CO), formate, and methanol, via the Wood-Ljungdahl pathway (WLP) to produce biofuels and biochemicals.
Jihyun Yu, Jihyun Yu, Mi-Jeong Park, Joungmin Lee, Soo Jae Kwon, Soo Jae Kwon, Jae Kyu Lim, Jae Kyu Lim, Hyun Sook Lee, Hyun Sook Lee, Sung Gyun Kang, Sung Gyun Kang, Jung-Hyun Lee, Jung-Hyun Lee, Kae Kyoung Kwon, Kae Kyoung Kwon, Yun Jae Kim, Yun Jae Kim   +17 more
doaj   +1 more source

The toxic side of one-carbon metabolism and epigenetics

Redox Biology, 2021
One-carbon metabolism is a central metabolic hub that provides one-carbon units for essential biosynthetic reactions and for writing epigenetics marks.
Agustín E. Morellato, Carla Umansky, Lucas B. Pontel   +2 more
doaj   +1 more source

Genome-wide analysis of the UDP-glucose dehydrogenase gene family in Arabidopsis, a key enzyme for matrix polysaccharides in cell walls [PDF]

, 2007
Arabidopsis cell walls contain large amounts of pectins and hemicelluloses, which are predominantly synthesized via the common precursor UDP-glucuronic acid.
Tenhaken, Raimund, Klinghammer, Michaela
core   +1 more source

Proteome- and Transcriptome-Driven Reconstruction of the Human Myocyte Metabolic Network and Its Use for Identification of Markers for Diabetes

Cell Reports, 2015
Skeletal myocytes are metabolically active and susceptible to insulin resistance and are thus implicated in type 2 diabetes (T2D). This complex disease involves systemic metabolic changes, and their elucidation at the systems level requires genome-wide ...
Leif Väremo, Camilla Scheele, Christa Broholm, Adil Mardinoglu, Caroline Kampf, Anna Asplund, Intawat Nookaew, Mathias Uhlén, Bente Klarlund Pedersen, Jens Nielsen   +9 more
doaj   +1 more source