Incomplete Wood-Ljungdahl pathway facilitates one-carbon metabolism in organohalide-respiring Dehalococcoides mccartyi. [PDF]
, 2014 The acetyl-CoA "Wood-Ljungdahl" pathway couples the folate-mediated one-carbon (C1) metabolism to either CO2 reduction or acetate oxidation via acetyl-CoA.
Alvarez-Cohen, Lisa +8 more
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Expression and Role of Methylenetetrahydrofolate Dehydrogenase 1 Like (MTHFD1L) in Bladder Cancer
Translational Oncology, 2019 Cancer cells utilize vitamin folate to fulfill their excessive demand for nucleotides and amino acids. Dihydrofolate reductase (DHFR), an enzyme involved in folate metabolism converts dihydrofolate into tetrahydrofolate, which is required for the de novo
Marie-Lisa Eich +9 more
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Comparative genomics and mutagenesis analyses of choline metabolism in the marine Roseobacter clade [PDF]
, 2015 Choline is ubiquitous in marine eukaryotes and appears to be widely distributed in surface marine waters; however, its metabolism by marine bacteria is poorly understood.
Andresen P.A. +6 more
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Remaining challenges in cellular flavin cofactor homeostasis and flavoprotein biogenesis
Frontiers in Chemistry, 2015 The primary role of the water-soluble vitamin B2 (riboflavin) in cell biology is connected with its conversion into FMN and FAD, the cofactors of a large number of dehydrogenases, oxidases and reductases involved in energetic metabolism, epigenetics ...
Teresa Anna eGiancaspero +9 more
doaj +1 more source
Cancer proteome and metabolite changes linked to SHMT2.
PLoS ONE, 2020 Serine hydroxymethyltransferase 2 (SHMT2) converts serine plus tetrahydrofolate (THF) into glycine plus methylene-THF and is upregulated at the protein level in lung and other cancers.
Jiefei Tong +19 more
doaj +2 more sources
Scientific Reports, 2023 Tumor cells generally require large amounts of nucleotides, and thus activate de novo purine synthesis (dnPS). In the dnPS reactions, 10-formyltetrahydorofolate (10-fTHF) supplied by one-carbon metabolism is utilized as a formyl group donor.
Masato Sasaki +9 more
doaj +1 more source
Current knowledge and recent advances in understanding metabolism of the model cyanobacterium Synechocystis sp. PCC 6803 [PDF]
, 2020 Cyanobacteria are key organisms in the global ecosystem, useful models for studying metabolic and physiological processes conserved in photosynthetic organisms, and potential renewable platforms for production of chemicals.
Lea-Smith, David +2 more
core +3 more sources
Biomédica: revista del Instituto Nacional de Salud, 2013 Introducción. La dihidrofolato reductasa (DHFR) se ha utilizado como blanco molecular en tratamientos antibacterianos, anticancerígenos y antipalúdicos.
Edison Osorio +4 more
doaj +1 more source
Genomic potential and physiological characteristics of C1 metabolism in novel acetogenic bacteria
Frontiers in Microbiology, 2023 Acetogenic bacteria can utilize C1 compounds, such as carbon monoxide (CO), formate, and methanol, via the Wood-Ljungdahl pathway (WLP) to produce biofuels and biochemicals.
Jihyun Yu +17 more
doaj +1 more source
The toxic side of one-carbon metabolism and epigenetics
Redox Biology, 2021 One-carbon metabolism is a central metabolic hub that provides one-carbon units for essential biosynthetic reactions and for writing epigenetics marks.
Agustín E. Morellato +2 more
doaj +1 more source