Results 21 to 30 of about 8,933 (186)

Amino acid metabolism of the thermophilic acetogen Thermacetogenium phaeum. [PDF]

PLoS ONE
Anaerobic microbial degradation of the amino acids glycine and serine either occurs through enzymes of the so-called Stickland reaction or alternatively through the glycine cleavage system (GCS).
Yanlin Cai, Andreas Marquardt, David Schleheck, Nicolai Müller   +3 more
doaj   +2 more sources

Activated brown adipose tissue releases exosomes containing mitochondrial methylene tetrahydrofolate dehydrogenase (NADP dependent) 1-like protein (MTHFD1L). [PDF]

Biosci Rep, 2022
Brown adipose tissue (BAT) is a promising weapon to combat obesity and metabolic disease. BAT is thermogenic and consumes substantial amounts of glucose and fatty acids as fuel for thermogenesis and energy expenditure.
Leow MK, Rengaraj A, Narasimhan K, Verma SK, Yaligar J, Thu GLT, Sun L, Goh HJ, Govindharajulu P, Sadananthan SA, Michael N, Meng W, Gallart-Palau X, Sun L, Karnani N, Sze NSK, Velan SS.   +16 more
europepmc   +2 more sources

Engineering serine metabolism to enhance AOX1 promoter self-induction in formate dehydrogenase-deficient Komagataella phaffii [PDF]

Microbial Cell Factories
Background The methylotrophic yeast Komagataella phaffii is a premier host for recombinant protein (rProt) production, which traditionally relies on methanol induction of the alcohol oxidase 1 promoter (P AOX1 ).
Rocio Cozmar, Julio Berrios, Patrick Fickers   +2 more
doaj   +2 more sources

Prevalence and determinants of folic acid uptake among women of childbearing age in the Ho municipality of the volta region of Ghana

International Journal of Food Properties, 2022
Folic acid is an essential vitamin that is found in certain green lush vegetables, such as kale, spinach, and cabbage. An estimated 300,000 children are born with NTDs globally each year resulting in the death of approximately 88,000.
Lucy Makafui Nutakor, Stephen Manortey
doaj   +1 more source

Genetic polymorphism rs6922269 in the MTHFD1L gene is associated with survival and baseline active vitamin B12 levels in post-acute coronary syndromes patients. [PDF]

PLoS ONE, 2014
BACKGROUND AND AIMS: The methylene-tetrahydrofolate dehydrogenase (NADP+ dependent) 1-like (MTHFD1L) gene is involved in mitochondrial tetrahydrofolate metabolism.
Barry R Palmer, Sandy Slow, Katrina L Ellis, Anna P Pilbrow, Lorraine Skelton, Chris M Frampton, Suetonia C Palmer, Richard W Troughton, Tim G Yandle, Rob N Doughty, Gillian A Whalley, Michael Lever, Peter M George, Stephen T Chambers, Chris Ellis, A Mark Richards, Vicky A Cameron   +16 more
doaj   +1 more source

A Common Polymorphism in the MTHFD1 Gene Is a Modulator of Risk of Congenital Heart Disease

Journal of Cardiovascular Development and Disease, 2022
Several environmental and genetic factors may influence the risk of congenital heart defects (CHDs), which can have a substantial impact on pediatric morbidity and mortality. We investigated the association of polymorphisms in the genes of the folate and
Nataša Karas Kuželički, Alenka Šmid, Maša Vidmar Golja, Tina Kek, Borut Geršak, Uroš Mazič, Irena Mlinarič-Raščan, Ksenija Geršak   +7 more
doaj   +1 more source

Folate Related Pathway Gene Analysis Reveals a Novel Metabolic Variant Associated with Alzheimer’s Disease with a Change in Metabolic Profile

Metabolites, 2022
Metabolic disorders may be important potential causative pathways to Alzheimer’s disease (AD). Cerebrospinal fluid (CSF) decreasing output, raised intracranial pressure, and ventricular enlargement have all been linked to AD.
Jaleel Miyan, Charlotte Buttercase, Emma Beswick, Salma Miyan, Ghazaleh Moshkdanian, Naila Naz   +5 more
doaj   +1 more source

Metagenome Assembled Genome of a Novel Verrucomicrobial Methanotroph From Pantelleria Island

Frontiers in Microbiology, 2021
Verrucomicrobial methanotrophs are a group of aerobic bacteria isolated from volcanic environments. They are acidophiles, characterized by the presence of a particulate methane monooxygenase (pMMO) and a XoxF-type methanol dehydrogenase (MDH ...
Nunzia Picone, Pieter Blom, Carmen Hogendoorn, Jeroen Frank, Theo van Alen, Arjan Pol, Antonina L. Gagliano, Mike S. M. Jetten, Walter D’Alessandro, Paola Quatrini, Huub J. M. Op den Camp   +10 more
doaj   +1 more source

Sex-Specific Metabolic Effects of Dietary Folate Withdrawal in Wild-Type and Aldh1l1 Knockout Mice

Metabolites, 2022
ALDH1L1 (10-formyltetrahydrofolate dehydrogenase), an enzyme of folate metabolism, is highly expressed in the liver. It regulates the overall flux of folate-bound one-carbon groups by converting 10-formyltetrahydrofolate to tetrahydrofolate and CO2 in a ...
Jaspreet Sharma, Blake R. Rushing, Madeline S. Hall, Kristi L. Helke, Susan L. McRitchie, Natalia I. Krupenko, Susan J. Sumner, Sergey A. Krupenko   +7 more
doaj   +1 more source

Expression and Role of Methylenetetrahydrofolate Dehydrogenase 1 Like (MTHFD1L) in Bladder Cancer

Translational Oncology, 2019
Cancer cells utilize vitamin folate to fulfill their excessive demand for nucleotides and amino acids. Dihydrofolate reductase (DHFR), an enzyme involved in folate metabolism converts dihydrofolate into tetrahydrofolate, which is required for the de novo
Marie-Lisa Eich, Maria Del Carmen Rodriguez Pena, Darshan Shimoga Chandrashekar, Alcides Chaux, Sumit Agarwal, Jennifer B. Gordetsky, James E. Ferguson, Guru P. Sonpavde, George J. Netto, Sooryanarayana Varambally   +9 more
doaj   +1 more source