Results 11 to 20 of about 155,408 (190)

A Challenging Case of Acute Methotrexate Toxicity. [PDF]

Clin Case Rep
ABSTRACT Catastrophic methotrexate toxicity, characterized by life‐threatening pancytopenia and neutropenic enterocolitis, may occur even after a single low therapeutic dose, particularly in patients with renal impairment or dehydration. Early recognition and prompt multidisciplinary management are essential to improve outcomes.
Asgari S, Alizadeh N, Zaresharifi S, Farzin M.   +3 more
europepmc   +2 more sources

Methanol Metabolism in the Cytochrome and Menaquinone-Containing Acetogen Moorella thermoacetica. [PDF]

Environ Microbiol
The thermophilic acetogenic bacterium Moorella thermoacetica is a promising platform organism to convert C1 compounds to valuable products. Gaseous C1 substrates are technically difficult to use for fermentation in an industrial scale, but methanol, which can be produced chemically from carbon dioxide, is a suitable alternative.
Rosenbaum FP, Poehlein A, Daniel R, Müller V.   +3 more
europepmc   +2 more sources

Antibodies to the glutamate dehydrogenase of Plasmodium falciparum [PDF]

, 1986
Polyclonal antisera raised against Plasmodium knowlesi reacted with NADP-specific glutamate dehydrogenase (GLDH) of P. knowlesi, GLDH of P. falciparum and GLDH of Proteus spp. The antisera did not react with NAD(P) GLDH from bovine liver.
Cooksley, S, Wilson, R J, Hempelmann, E, Ling, I T, Bates, P A   +4 more
core   +4 more sources

Prevalence and determinants of folic acid uptake among women of childbearing age in the Ho municipality of the volta region of Ghana

International Journal of Food Properties, 2022
Folic acid is an essential vitamin that is found in certain green lush vegetables, such as kale, spinach, and cabbage. An estimated 300,000 children are born with NTDs globally each year resulting in the death of approximately 88,000.
Lucy Makafui Nutakor, Stephen Manortey
doaj   +1 more source

A Common Polymorphism in the MTHFD1 Gene Is a Modulator of Risk of Congenital Heart Disease

Journal of Cardiovascular Development and Disease, 2022
Several environmental and genetic factors may influence the risk of congenital heart defects (CHDs), which can have a substantial impact on pediatric morbidity and mortality. We investigated the association of polymorphisms in the genes of the folate and
Nataša Karas Kuželički, Alenka Šmid, Maša Vidmar Golja, Tina Kek, Borut Geršak, Uroš Mazič, Irena Mlinarič-Raščan, Ksenija Geršak   +7 more
doaj   +1 more source

Genetic polymorphism rs6922269 in the MTHFD1L gene is associated with survival and baseline active vitamin B12 levels in post-acute coronary syndromes patients. [PDF]

PLoS ONE, 2014
BACKGROUND AND AIMS: The methylene-tetrahydrofolate dehydrogenase (NADP+ dependent) 1-like (MTHFD1L) gene is involved in mitochondrial tetrahydrofolate metabolism.
Barry R Palmer, Sandy Slow, Katrina L Ellis, Anna P Pilbrow, Lorraine Skelton, Chris M Frampton, Suetonia C Palmer, Richard W Troughton, Tim G Yandle, Rob N Doughty, Gillian A Whalley, Michael Lever, Peter M George, Stephen T Chambers, Chris Ellis, A Mark Richards, Vicky A Cameron   +16 more
doaj   +1 more source

Folate Related Pathway Gene Analysis Reveals a Novel Metabolic Variant Associated with Alzheimer’s Disease with a Change in Metabolic Profile

Metabolites, 2022
Metabolic disorders may be important potential causative pathways to Alzheimer’s disease (AD). Cerebrospinal fluid (CSF) decreasing output, raised intracranial pressure, and ventricular enlargement have all been linked to AD.
Jaleel Miyan, Charlotte Buttercase, Emma Beswick, Salma Miyan, Ghazaleh Moshkdanian, Naila Naz   +5 more
doaj   +1 more source

Microbial Electrosynthesis Reshapes Energy Metabolism and Physiology in Clostridium ljungdahlii. [PDF]

Microb Biotechnol
Microbial electrosynthesis drives Clostridium ljungdahlii into a distinct stress‐associated physiological state, different from gas fermentation. Comparative multi‐omics and electron microscopy reveal physiological constraints that help explain the poor performance of MES.
Al Sbei S, Boto ST, Krüger T, Papenfort K, Westermann M, Jost A, Harnisch F, Brakhage AA, Rosenbaum MA.   +8 more
europepmc   +2 more sources

Metagenome Assembled Genome of a Novel Verrucomicrobial Methanotroph From Pantelleria Island

Frontiers in Microbiology, 2021
Verrucomicrobial methanotrophs are a group of aerobic bacteria isolated from volcanic environments. They are acidophiles, characterized by the presence of a particulate methane monooxygenase (pMMO) and a XoxF-type methanol dehydrogenase (MDH ...
Nunzia Picone, Pieter Blom, Carmen Hogendoorn, Jeroen Frank, Theo van Alen, Arjan Pol, Antonina L. Gagliano, Mike S. M. Jetten, Walter D’Alessandro, Paola Quatrini, Huub J. M. Op den Camp   +10 more
doaj   +1 more source

Sex-Specific Metabolic Effects of Dietary Folate Withdrawal in Wild-Type and Aldh1l1 Knockout Mice

Metabolites, 2022
ALDH1L1 (10-formyltetrahydrofolate dehydrogenase), an enzyme of folate metabolism, is highly expressed in the liver. It regulates the overall flux of folate-bound one-carbon groups by converting 10-formyltetrahydrofolate to tetrahydrofolate and CO2 in a ...
Jaspreet Sharma, Blake R. Rushing, Madeline S. Hall, Kristi L. Helke, Susan L. McRitchie, Natalia I. Krupenko, Susan J. Sumner, Sergey A. Krupenko   +7 more
doaj   +1 more source