Results 11 to 20 of about 8,933 (186)

A Detoxification Enzyme for Apis mellifera Newly Characterized by Recombinant Expression: 10-Formyl Tetrahydrofolate Dehydrogenase. [PDF]

Front Insect Sci, 2022
Honeybees are important managed pollinators that perform important ecological and economic functions. In recent decades, the obligate ectoparasite Varroa destructor severely affected survival of honeybees as it either feeds on hemolymph and fat bodies or acts as a vector for viruses.
Mating M, Sharbati S, Einspanier R.
europepmc   +5 more sources

Folate in demethylation: The crystal structure of the rat dimethylglycine dehydrogenase complexed with tetrahydrofolate

Biochemical and Biophysical Research Communications, 2014
Dimethylglycine dehydrogenase (DMGDH) is a mammalian mitochondrial enzyme which plays an important role in the utilization of methyl groups derived from choline. DMGDH is a flavin containing enzyme which catalyzes the oxidative demethylation of dimethylglycine in vitro with the formation of sarcosine (N-methylglycine), hydrogen peroxide and ...
Zigmund Luka, Svetlana Pakhomova, Lioudmila V Loukachevitch   +2 more
exaly   +6 more sources

Non-canonical dihydrolipoyl transacetylase promotes chemotherapy resistance via mitochondrial tetrahydrofolate signaling [PDF]

Nature Communications
Chemotherapy is often a primary treatment for cancer. However, resistance leads to therapeutic failure. Acetylation dynamics play important regulatory roles in cancer cells, but the mechanisms by which acetylation mediates therapy resistance remain ...
Jung Seok Hwang, JiHoon Kang, Jaehyun Kim, Kiyoung Eun, Sophia West, Hannah E. Bacho, Vanessa Avalos, Sydney Shuff, Dong M. Shin, Nabil F. Saba, Kelly R. Magliocca, Cheng-Kui Qu, Haian Fu, Suresh S. Ramalingam, Andrey A. Ivanov, Taro Hitosugi, Sumin Kang   +16 more
doaj   +3 more sources

Methylene tetrahydrofolate dehydrogenase 2 (MTHFD2) is overexpressed in head and neck squamous cell carcinoma (HNSCC) and correlated with patient’s poor prognosis

Pteridines, 2021
To investigate methylene tetrahydrofolate dehydrogenase 2 (MTHFD2) expression, biological function, and correlation with head and neck squamous cell carcinoma (HNSCC) patient’s prognosis.
Sun Biqiang, He Zhijun, Liu Gan, Fu Xiao, Chen Zhiyong, Li Guoli   +5 more
doaj   +2 more sources

Crystal Structure and Sequence Analysis of N⁵, N¹⁰-Methylenetetrahydrofolate Dehydrogenase/Cyclohydrolase Enzyme from Porphyromonas gingivalis

Crystals, 2023
The methylenetetrahydrofolate dehydrogenase–cyclohydrolase (FolD) enzyme has a dual activity of N5,N10-methylenetetrahydrofolate dehydrogenase and cyclohydrolase.
Sehyeok Im, Hackwon Do, Jisub Hwang, Youn-Soo Shim, Jun Hyuck Lee   +4 more
doaj   +2 more sources

Microbial Electrosynthesis Reshapes Energy Metabolism and Physiology in Clostridium ljungdahlii. [PDF]

Microb Biotechnol
Microbial electrosynthesis drives Clostridium ljungdahlii into a distinct stress‐associated physiological state, different from gas fermentation. Comparative multi‐omics and electron microscopy reveal physiological constraints that help explain the poor performance of MES.
Al Sbei S, Boto ST, Krüger T, Papenfort K, Westermann M, Jost A, Harnisch F, Brakhage AA, Rosenbaum MA.   +8 more
europepmc   +2 more sources

Genomic and Transcriptomic Insights Into the Autotrophic Metabolism on H₂ + CO₂ or CO of the Thermophilic Acetogenic Model Organism Moorella thermoacetica. [PDF]

Environ Microbiol
Moorella thermoacetica is the model organism for elucidation of acetogenesis. The reduction of CO2 to acetate is well studied, but how redox carrier balancing and energy conservation are maintained during autotrophic growth and how H2 is oxidised remains enigmatic.
Rosenbaum FP, Poehlein A, Daniel R, Müller V.   +3 more
europepmc   +2 more sources

Sorbitol Uptake and Oxygen Transfer Shape AOX1 Promoter Induction in Formate Dehydrogenase‐Deficient Komagataella phaffii [PDF]

Microbial Biotechnology
In Komagataella phaffii, the use of formate as an AOX1 promoter (PAOX1) inducer in combination with sorbitol, a non‐repressive carbon source, has emerged as a promising alternative to methanol‐based expression systems.
Cristina Bustos, Rocio Cozmar, Julio Berrios, Patrick Fickers   +3 more
doaj   +2 more sources

The crystal structure of a bacterial, bifunctional 5, 10 methylene‐tetrahydrofolate dehydrogenase/cyclohydrolase [PDF]

Protein Science, 1999
AbstractThe structure of a bifunctional 5, 10‐methylene‐tetrahydrofolate dehydrogenase/cyclohydrolase from Escherichia coli has been determined at 2.5 Å resolution in the absence of bound substrates and compared to the NADP‐bound structure of the homologous enzyme domains from a trifunctional human synthetase enzyme.
Betty W Shen, Barry L Stoddard
exaly   +3 more sources

The role of tetrahydrofolate dehydrogenase in the hepatic supply of tetrahydrobiopterin in rats [PDF]

Biochemical Journal, 1976
The reduction of 7,8-dihydrobiopterin to 5,6,7,8-tetrahydrobiopterin by rat liver tetrahydrofolate dehydrogenase (5,6,7,8-tetrahydrofolate-NADP+ oxidoreductase, EC 1.5.1.3) is competitively inhibited by trimethoprim lactate (apparent Ki 0.285 muM). An apparent Michaelis constant of 43 muM for dihydrobiopterin was obtained, which is 430 times higher ...
exaly   +3 more sources