Results 31 to 40 of about 8,772 (148)

The correlation between MTHFD2 and the tumor microenvironment in head and neck squamous cell carcinoma [PDF]

Yixue xinzhi zazhi
Objective To investigate the expression, biological function, related signaling pathways, tumor mutation burden (TMB), immune infiltration and prognosis of methylene tetrahydrofolate dehydrogenase 2 (MTHFD2) in head and neck squamous carcinoma (HNSCC) by
SHI Zhenxiang, WU Sa, CAI Weisong, MING Xiaoping, CHEN Xiong   +4 more
doaj   +1 more source

The effect of tetrahydrofolate on the reduction of electron transfer flavoprotein by sarcosine and dimethylglycine dehydrogenases [PDF]

Biochemical Journal, 1982
Pig liver electron transfer flavoprotein (ETF) is rapidly reduced by sarcosine and dimethylglycine dehydrogenases to the anionic semiquinone form, the subsequent formation of the flavoquinol form being a much slower process. In the presence of tetrahydrofolate the yield of anionic semiquinone at the end of the rapid phase of reduction of ETF is only ...
D J, Steenkamp, M, Husain
openaire   +2 more sources

Dementia revealed: novel chromosome 6 locus for late-onset Alzheimer disease provides genetic evidence for folate-pathway abnormalities. [PDF]

PLoS Genetics, 2010
Genome-wide association studies (GWAS) of late-onset Alzheimer disease (LOAD) have consistently observed strong evidence of association with polymorphisms in APOE.
Adam C Naj, Gary W Beecham, Eden R Martin, Paul J Gallins, Eric H Powell, Ioanna Konidari, Patrice L Whitehead, Guiqing Cai, Vahram Haroutunian, William K Scott, Jeffery M Vance, Michael A Slifer, Harry E Gwirtsman, John R Gilbert, Jonathan L Haines, Joseph D Buxbaum, Margaret A Pericak-Vance   +16 more
doaj   +1 more source

Flavin-Based Electron Bifurcation, Ferredoxin, Flavodoxin, and Anaerobic Respiration With Protons (Ech) or NAD+ (Rnf) as Electron Acceptors: A Historical Review

Frontiers in Microbiology, 2018
Flavin-based electron bifurcation is a newly discovered mechanism, by which a hydride electron pair from NAD(P)H, coenzyme F420H2, H2, or formate is split by flavoproteins into one-electron with a more negative reduction potential and one with a more ...
Wolfgang Buckel, Rudolf K. Thauer
doaj   +1 more source

Extending the Farquhar–von Caemmerer–Berry photosynthesis model to account for various photorespiratory bypasses

New Phytologist, EarlyView.
We extend a widely used C3‐photosynthesis model to account for various photorespiratory bypasses, thereby, providing a useful resource and framework that enforces future novel bypass work and scrutinize if the results go counter to theory. Our model analyses show that of the 17 published bypass pathways, full‐decarboxylating bypasses (that have been ...
Xinyou Yin, Kaining Jin, Guoxin Chen, Tiegang Lu   +3 more
wiley   +1 more source

Edible Insect Allergens: An Emerging Food Safety Challenge

Sustainable Food Proteins, Volume 4, Issue 3, September 2026.
Allergic responses to edible insects arise via two main pathways: cross‐reactivity with homologous arthropod allergens and primary sensitization to edible insect proteins, both leading to IgE‐mediated immune activation. ABSTRACT Edible insects are increasingly promoted as sustainable protein sources; however, their allergenic potential remains a ...
Changqi Liu, Cassandra Maya, John J. Love, Huilian Che, Ke Chen, Jing Zhao   +5 more
wiley   +1 more source

The pugilistDominant Mutation of Drosophila melanogaster: A Simple-Sequence Repeat Disorder Reveals Localized Transport in the Eye.

PLoS ONE, 2016
The pugilist-Dominant mutation results from fusion of a portion of the gene encoding the tri-functional Methylene Tetrahydrofolate Dehydrogenase (E.C.1.5.1.5, E.C.3.5.4.9, E.C.6.3.4.3) to approximately one kb of a heterochromatic satellite repeat ...
Yikang S Rong, Mary M Golic, Kent G Golic   +2 more
doaj   +1 more source

Aldh1l2 knockout mouse metabolomics links the loss of the mitochondrial folate enzyme to deregulation of a lipid metabolism observed in rare human disorder

Human Genomics, 2020
Background Mitochondrial folate enzyme ALDH1L2 (aldehyde dehydrogenase 1 family member L2) converts 10-formyltetrahydrofolate to tetrahydrofolate and CO2 simultaneously producing NADPH.
Natalia I. Krupenko, Jaspreet Sharma, Peter Pediaditakis, Kristi L. Helke, Madeline S. Hall, Xiuxia Du, Susan Sumner, Sergey A. Krupenko   +7 more
doaj   +1 more source

De novo or Salvage? Nucleotide Availability as a Driver of Bacterial Adaptation and Virulence

MicrobiologyOpen, Volume 15, Issue 4, August 2026.
Bacterial pathogens survive in different host environments by switching between making nucleotides by de novo synthesis and scavenging them from the host. This flexibility supports growth and virulence making nucleotide metabolism an attractive therapeutic target.
Riya Joshi, Alastair G. McEwan, Ulrike Kappler   +2 more
wiley   +1 more source

Nucleotide Metabolism in Health and Disease

MedComm, Volume 7, Issue 8, August 2026.
Nucleotide metabolism, including de novo synthesis, salvage pathways, and catabolism, when dysregulated contributes to cancer, immune disorders, metabolic and urological diseases, and radiation injury. Metabolites such as adenosine, cGAMP, NAD, and cAMP and enzymes like RNR are promising therapeutic targets and biomarkers.
Xiaoying Zhao, Yiyu Zeng, Yike Xu, Shu Rao, Mouna Khouchani, Hassna Soummane, Jingyi Li, Rui Liu   +7 more
wiley   +1 more source