Results 31 to 40 of about 155,408 (190)

Nitric oxide modulates folate-mediated one-carbon metabolism and mitochondrial energy levels of peaches during cold storage

Frontiers in Nutrition, 2023
Folate-mediated one-carbon metabolism (FOCM) is closely associated with postharvest preservation. This study investigated the effects of exogenous nitric oxide (NO) on FOCM, storage quality, energy metabolism, and mitochondrial membrane integrity in cold-
Zhifeng Yang, Shuhua Zhu, Shuhua Zhu, Xiaoyu Wang, Changbao Chen, Dandan Huang, Jianrong Feng   +6 more
doaj   +1 more source

A systems biology approach uncovers cellular strategies used by Methylobacterium extorquens AM1 during the switch from multi- to single-carbon growth. [PDF]

PLoS ONE, 2010
When organisms experience environmental change, how does their metabolic network reset and adapt to the new condition? Methylobacterium extorquens is a bacterium capable of growth on both multi- and single-carbon compounds.
Elizabeth Skovran, Gregory J Crowther, Xiaofeng Guo, Song Yang, Mary E Lidstrom   +4 more
doaj   +1 more source

Exploring Different Drug Targets Responsible for the Inhibitory Activity of N, N′-Substituted Diamine Derivatives in Leishmania

Engineering Proceedings, 2023
The genome sequence of Leishmania has given rise to diverse novel drug targets, and their identification remains the first step in drug discovery. This study aims to identify the possible anti-leishmanicidal activity target(s) of N1, N4-[dibenzylbutane-4′
Ikenna F. Ezema, Victor C. Akwu, Obinna K. Didigwu, Jude E. Ogbonna, Augustine C. Ugwu, Charles O. Nnadi   +5 more
doaj   +1 more source

The correlation between MTHFD2 and the tumor microenvironment in head and neck squamous cell carcinoma [PDF]

Yixue xinzhi zazhi
Objective To investigate the expression, biological function, related signaling pathways, tumor mutation burden (TMB), immune infiltration and prognosis of methylene tetrahydrofolate dehydrogenase 2 (MTHFD2) in head and neck squamous carcinoma (HNSCC) by
SHI Zhenxiang, WU Sa, CAI Weisong, MING Xiaoping, CHEN Xiong   +4 more
doaj   +1 more source

The effect of tetrahydrofolate on the reduction of electron transfer flavoprotein by sarcosine and dimethylglycine dehydrogenases [PDF]

Biochemical Journal, 1982
Pig liver electron transfer flavoprotein (ETF) is rapidly reduced by sarcosine and dimethylglycine dehydrogenases to the anionic semiquinone form, the subsequent formation of the flavoquinol form being a much slower process. In the presence of tetrahydrofolate the yield of anionic semiquinone at the end of the rapid phase of reduction of ETF is only ...
D J, Steenkamp, M, Husain
openaire   +2 more sources

Hypertension in mice lacking 11beta-hydroxysteroid dehydrogenase type 2 [PDF]

, 1999
Deficiency of 11beta-hydroxysteroid dehydrogenase type 2 (11beta-HSD2) in humans leads to the syndrome of apparent mineralocorticoid excess (SAME), in which cortisol illicitly occupies mineralocorticoid receptors, causing sodium retention, hypokalemia ...
Mullins, A J, Edwards, Christopher R. W., Seckl, Jonathan R., Jonathan R. Seckl, Christopher R.W. Edwards, Stewart Fleming, Kotelevtsev, Yuri, John J. Mullins, Kotelevtsev, Y, Kenyon, C, Seckl, J R, Mullins, John J., Edwards, C R W, Fleming, S, Christopher Kenyon, Kenyon, Christopher, Brown, R W, Yuri Kotelevtsev, Roger W. Brown   +18 more
core   +1 more source

Aldehyde dehydrogenase 1A1 and gelsolin identified as novel invasion-modulating factors in conditioned medium of pancreatic cancer cells [PDF]

, 2008
Conditioned medium (CM) from clonal sub-populations of the pancreatic cancer cell line, MiaPaCa-2 with differing invasive abilities, were examined for their effect on in vitro invasion.
Naomi Walsh, Martin Clynes, Clynes, Martin, O'Donovan, Norma, Michael Henry, Walsh, Naomi, Dowling, Paul, Paula Meleady, Meleady, Paula, Norma O'Donovan, O\u27Donovan, Norma, Henry, Michael, Paul Dowling   +12 more
core   +2 more sources

Molecular genetics and pathophysiology of 17 beta-hydroxysteroid dehydrogenase 3 deficiency. [PDF]

, 1996
Autosomal recessive mutations in the 17 beta-hydroxysteroid dehydrogenase 3 gene impair the formation of testosterone in the fetal testis and give rise to genetic males with female external genitalia.
Blethen, Sandra L., Geissler, Wayne M., Mendonca, Berenice B., Schwarz, Hans P., Russell, David D., Bloise, Walter, Grumbach, Melvin M., Davis, Daphne L., Andersson, Stefan, New, Maria I., Wu, Ling, Witchel, Selma F., Griffin, James E., Cutler Jr., Gordon B., Wilson, Jean D.   +14 more
core   +1 more source

Dementia revealed: novel chromosome 6 locus for late-onset Alzheimer disease provides genetic evidence for folate-pathway abnormalities. [PDF]

PLoS Genetics, 2010
Genome-wide association studies (GWAS) of late-onset Alzheimer disease (LOAD) have consistently observed strong evidence of association with polymorphisms in APOE.
Adam C Naj, Gary W Beecham, Eden R Martin, Paul J Gallins, Eric H Powell, Ioanna Konidari, Patrice L Whitehead, Guiqing Cai, Vahram Haroutunian, William K Scott, Jeffery M Vance, Michael A Slifer, Harry E Gwirtsman, John R Gilbert, Jonathan L Haines, Joseph D Buxbaum, Margaret A Pericak-Vance   +16 more
doaj   +1 more source

Functional characterization of SlscADH1, a fruit-ripening associated short-chain alcohol dehydrogenase of tomato [PDF]

, 2012
A tomato short-chain dehydrogenase-reductase (SlscADH1) is preferentially expressed in fruit with a maximum expression at the breaker stage while expression in roots, stems, leaves and flowers is very weak.
Moummou, Hanane, Chervin, Christian, Latché, Alain, Pech, Jean-Claude, Benichou, Mohamed, Tonfack, Libert Brice, Ginies, Christian, Van der Rest, Benoît, Youmbi, Emmanuel   +8 more
core   +1 more source