Results 31 to 40 of about 8,933 (186)

Remaining challenges in cellular flavin cofactor homeostasis and flavoprotein biogenesis

Frontiers in Chemistry, 2015
The primary role of the water-soluble vitamin B2 (riboflavin) in cell biology is connected with its conversion into FMN and FAD, the cofactors of a large number of dehydrogenases, oxidases and reductases involved in energetic metabolism, epigenetics ...
Teresa Anna eGiancaspero, Matilde eColella, Carmen eBrizio, Graziana eDifonzo, Giuseppina Maria eFiorino, Piero eLeone, Roderich eBrandsch, Francesco eBonomi, Stefania eIametti, Maria eBarile   +9 more
doaj   +1 more source

Cancer proteome and metabolite changes linked to SHMT2.

PLoS ONE, 2020
Serine hydroxymethyltransferase 2 (SHMT2) converts serine plus tetrahydrofolate (THF) into glycine plus methylene-THF and is upregulated at the protein level in lung and other cancers.
Jiefei Tong, Jonathan R Krieger, Paul Taylor, Rick Bagshaw, Jae Kang, Swathi Jeedigunta, Leanne E Wybenga-Groot, Wen Zhang, Heba Badr, Shideh Mirhadi, Nhu-An Pham, Étienne Coyaud, Man Yu, Ming Li, Michael Cabanero, Brian Raught, Jason T Maynes, Cynthia Hawkins, Ming Sound Tsao, Michael F Moran   +19 more
doaj   +2 more sources

One-carbon metabolizing enzyme ALDH1L1 influences mitochondrial metabolism through 5-aminoimidazole-4-carboxamide ribonucleotide accumulation and serine depletion, contributing to tumor suppression

Scientific Reports, 2023
Tumor cells generally require large amounts of nucleotides, and thus activate de novo purine synthesis (dnPS). In the dnPS reactions, 10-formyltetrahydorofolate (10-fTHF) supplied by one-carbon metabolism is utilized as a formyl group donor.
Masato Sasaki, Kazuo Yamamoto, Takeshi Ueda, Hayato Irokawa, Kouki Takeda, Ryoya Sekine, Fumie Itoh, Yutaka Tanaka, Shusuke Kuge, Nobuyuki Shibata   +9 more
doaj   +1 more source

Caracterización bioquímica de la enzima bifuncional dihidrofolato reductasa-timidilato sintasa de Leishmania (Viannia) y su evaluación como blanco molecular

Biomédica: revista del Instituto Nacional de Salud, 2013
Introducción. La dihidrofolato reductasa (DHFR) se ha utilizado como blanco molecular en tratamientos antibacterianos, anticancerígenos y antipalúdicos.
Edison Osorio, Carolina Aguilera, Nelson Naranjo, Marcel Marin, Carlos Muskus   +4 more
doaj   +1 more source

Genomic potential and physiological characteristics of C1 metabolism in novel acetogenic bacteria

Frontiers in Microbiology, 2023
Acetogenic bacteria can utilize C1 compounds, such as carbon monoxide (CO), formate, and methanol, via the Wood-Ljungdahl pathway (WLP) to produce biofuels and biochemicals.
Jihyun Yu, Jihyun Yu, Mi-Jeong Park, Joungmin Lee, Soo Jae Kwon, Soo Jae Kwon, Jae Kyu Lim, Jae Kyu Lim, Hyun Sook Lee, Hyun Sook Lee, Sung Gyun Kang, Sung Gyun Kang, Jung-Hyun Lee, Jung-Hyun Lee, Kae Kyoung Kwon, Kae Kyoung Kwon, Yun Jae Kim, Yun Jae Kim   +17 more
doaj   +1 more source

Neonatal hydrocephalus is a result of a block in folate handling and metabolism involving 10 formyl tetrahydrofolate dehydrogenase. [PDF]

, 2016
Folate is vital in a range of biological processes and folate deficiency is associated with neurodevelopmental disorders such as neural tube defects and hydrocephalus (HC).
Naz, Naila, Requena Jimenez, Alicia, Vilaplana, Anna, Megan Gurney, Miyan, Jaleel; id_orcid, Naila Naz, Alicia Requena Jimenez, Anna Sanjuan‐Vilaplana, Gurney, Megan, Jaleel Miyan   +9 more
core   +1 more source

The toxic side of one-carbon metabolism and epigenetics

Redox Biology, 2021
One-carbon metabolism is a central metabolic hub that provides one-carbon units for essential biosynthetic reactions and for writing epigenetics marks.
Agustín E. Morellato, Carla Umansky, Lucas B. Pontel   +2 more
doaj   +1 more source

Nitric oxide modulates folate-mediated one-carbon metabolism and mitochondrial energy levels of peaches during cold storage

Frontiers in Nutrition, 2023
Folate-mediated one-carbon metabolism (FOCM) is closely associated with postharvest preservation. This study investigated the effects of exogenous nitric oxide (NO) on FOCM, storage quality, energy metabolism, and mitochondrial membrane integrity in cold-
Zhifeng Yang, Shuhua Zhu, Shuhua Zhu, Xiaoyu Wang, Changbao Chen, Dandan Huang, Jianrong Feng   +6 more
doaj   +1 more source

A systems biology approach uncovers cellular strategies used by Methylobacterium extorquens AM1 during the switch from multi- to single-carbon growth. [PDF]

PLoS ONE, 2010
When organisms experience environmental change, how does their metabolic network reset and adapt to the new condition? Methylobacterium extorquens is a bacterium capable of growth on both multi- and single-carbon compounds.
Elizabeth Skovran, Gregory J Crowther, Xiaofeng Guo, Song Yang, Mary E Lidstrom   +4 more
doaj   +1 more source

Exploring Different Drug Targets Responsible for the Inhibitory Activity of N, N′-Substituted Diamine Derivatives in Leishmania

Engineering Proceedings, 2023
The genome sequence of Leishmania has given rise to diverse novel drug targets, and their identification remains the first step in drug discovery. This study aims to identify the possible anti-leishmanicidal activity target(s) of N1, N4-[dibenzylbutane-4′
Ikenna F. Ezema, Victor C. Akwu, Obinna K. Didigwu, Jude E. Ogbonna, Augustine C. Ugwu, Charles O. Nnadi   +5 more
doaj   +1 more source