Results 41 to 50 of about 8,933 (186)

Proteome- and Transcriptome-Driven Reconstruction of the Human Myocyte Metabolic Network and Its Use for Identification of Markers for Diabetes

Cell Reports, 2015
Skeletal myocytes are metabolically active and susceptible to insulin resistance and are thus implicated in type 2 diabetes (T2D). This complex disease involves systemic metabolic changes, and their elucidation at the systems level requires genome-wide ...
Leif Väremo, Camilla Scheele, Christa Broholm, Adil Mardinoglu, Caroline Kampf, Anna Asplund, Intawat Nookaew, Mathias Uhlén, Bente Klarlund Pedersen, Jens Nielsen   +9 more
doaj   +1 more source

The correlation between MTHFD2 and the tumor microenvironment in head and neck squamous cell carcinoma [PDF]

Yixue xinzhi zazhi
Objective To investigate the expression, biological function, related signaling pathways, tumor mutation burden (TMB), immune infiltration and prognosis of methylene tetrahydrofolate dehydrogenase 2 (MTHFD2) in head and neck squamous carcinoma (HNSCC) by
SHI Zhenxiang, WU Sa, CAI Weisong, MING Xiaoping, CHEN Xiong   +4 more
doaj   +1 more source

The effect of tetrahydrofolate on the reduction of electron transfer flavoprotein by sarcosine and dimethylglycine dehydrogenases [PDF]

Biochemical Journal, 1982
Pig liver electron transfer flavoprotein (ETF) is rapidly reduced by sarcosine and dimethylglycine dehydrogenases to the anionic semiquinone form, the subsequent formation of the flavoquinol form being a much slower process. In the presence of tetrahydrofolate the yield of anionic semiquinone at the end of the rapid phase of reduction of ETF is only ...
D J, Steenkamp, M, Husain
openaire   +2 more sources

Dementia revealed: novel chromosome 6 locus for late-onset Alzheimer disease provides genetic evidence for folate-pathway abnormalities. [PDF]

PLoS Genetics, 2010
Genome-wide association studies (GWAS) of late-onset Alzheimer disease (LOAD) have consistently observed strong evidence of association with polymorphisms in APOE.
Adam C Naj, Gary W Beecham, Eden R Martin, Paul J Gallins, Eric H Powell, Ioanna Konidari, Patrice L Whitehead, Guiqing Cai, Vahram Haroutunian, William K Scott, Jeffery M Vance, Michael A Slifer, Harry E Gwirtsman, John R Gilbert, Jonathan L Haines, Joseph D Buxbaum, Margaret A Pericak-Vance   +16 more
doaj   +1 more source

Transsulfuration pathway and antioxidant system.

, 2023
Tetrahydrofolate (THF); 5,10-methylene-tetrahydrofolate (5,10-Methylene-THF); methionine synthase (MS); methionine (Met);betaine homocysteine methyltransferase (BHMT); dimethylglycine (DMG); S-adenosylmethionine (SAM); methionine adenosyltransferase (MAT)
Levente Czeglédi (16846318), Endre Szilágyi (16846309), Piroska Bíróné Molnár (16846312), János Oláh (11726171), Melinda Paholcsek (658293), Georgina Pesti-Asbóth (16846306), László Babinszky (16846315), Judit Remenyik (10687154), László Stündl (12378762), Zoltán Cziáky (5197859)   +9 more
core   +1 more source

Flavin-Based Electron Bifurcation, Ferredoxin, Flavodoxin, and Anaerobic Respiration With Protons (Ech) or NAD+ (Rnf) as Electron Acceptors: A Historical Review

Frontiers in Microbiology, 2018
Flavin-based electron bifurcation is a newly discovered mechanism, by which a hydride electron pair from NAD(P)H, coenzyme F420H2, H2, or formate is split by flavoproteins into one-electron with a more negative reduction potential and one with a more ...
Wolfgang Buckel, Rudolf K. Thauer
doaj   +1 more source

Inherited metabolic epilepsies–established diseases, new approaches

Epilepsia Open, EarlyView.
Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley   +1 more source

DNA Methylation Shapes Seed‐Borne Microbiome and Proteome Responses During Early Maize‐Beneficial Bacteria Interactions

Plant, Cell &Environment, EarlyView.
ABSTRACT Microorganism and plant interactions are crucial for development and environmental adaptation. Plant growth promoting bacteria enhance agricultural productivity in a sustainable manner, while epigenetic modifications such as DNA methylation regulate gene expression and adaptive responses.
Pedro Igor Zocateli, Geovanna Vitória Olímpio, Felipe Astolpho de Almeida, Letícia Oliveira da Rocha, Diego Vinicius de Sena Martins, Sara Sangi, Fábio Lopes Olivares, Elyabe Monteiro de Matos, Juliana Siqueira, Lyderson Facio Viccini, Roberta Pena da Paschoa, Vanildo Silveira, Clícia Grativol   +12 more
wiley   +1 more source

Dihydropteridine Reductase as an Alternative to Dihydrofolate Reductase for Synthesis of Tetrahydrofolate in Thermus thermophilus

, 2004
A strategy devised to isolate a gene coding for a dihydrofolate reductase from Thermus thermophilus DNA delivered only clones harboring instead a gene (the T.
Legrain, Christiane, Glansdorff, Nicolas, Wilquet, Valérie, Van De Casteele, Christine, Gigot, Daniel   +4 more
core   +1 more source

The pugilistDominant Mutation of Drosophila melanogaster: A Simple-Sequence Repeat Disorder Reveals Localized Transport in the Eye.

PLoS ONE, 2016
The pugilist-Dominant mutation results from fusion of a portion of the gene encoding the tri-functional Methylene Tetrahydrofolate Dehydrogenase (E.C.1.5.1.5, E.C.3.5.4.9, E.C.6.3.4.3) to approximately one kb of a heterochromatic satellite repeat ...
Yikang S Rong, Mary M Golic, Kent G Golic   +2 more
doaj   +1 more source