Results 61 to 70 of about 8,933 (186)

Impact of Mutating the Key Residues of a Bifunctional 5,10-Methylenetetrahydrofolate Dehydrogenase-Cyclohydrolase from Escherichia coli on Its Activities

, 2015
Methylenetetrahydrofolate dehydrogenase-cyclohydrolase (FolD) catalyzes interconversion of 5,10-methylene-tetrahydrofolate and 10-formyl-tetrahydrofolate in the one-carbon metabolic pathway.
Varshney, Umesh, Sah, Shivjee, Shivjee Sah (550107), Umesh Varshney (195227)   +3 more
core   +1 more source

Synthesis of Amines for Active Pharmaceutical Ingredients Using the Whole‐Cell Factory Saccharomyces Cerevisae

ChemBioChem, Volume 27, Issue 9, 14 May 2026.
This review highlights advances in engineering Saccharomyces cerevisiae for the sustainable biocatalytic production of pharmaceutically relevant amines, amino alcohols, amino acids, and complex alkaloids. It focuses on strategies to increase productivity, including enhanced enzyme expression, cofactor regeneration, precursor channeling, pathway ...
Natalia Kwiatos, Stephen Ossel, Francesco G. Mutti   +2 more
wiley   +1 more source

Perspectives for Advancing Biotechnological Succinic Acid Production

Microbial Biotechnology, Volume 19, Issue 5, May 2026.
Succinic acid is an important molecule for sustainable chemical manufacturing, but its industrial production faces high costs and sustainability challenges, which are linked to feedstocks and excessive acid/base consumption. This opinion explores production routes based on next‐generation feedstocks and low‐pH fermentations to inspire novel cost ...
Christoph Gunkel, Bastian Blombach
wiley   +1 more source

Folate metabolic pathway.

, 2018
Depiction of folate uptake and reduction, transmethylation, and transulfuration pathways. Genes in the shaded circles were analyzed for single nucleotide polymorphisms.
Zhongxue Chen (137919), Shirisha Chittiboyina (2393389), Barbara A. Hocevar (539956), Lisa M. Kamendulis (306718), E. Gabriela Chiorean (539963)   +4 more
core   +1 more source

Electroenzymatic Cascades for Nitrogen Upgrading: Beyond Ammonia Towards Value‐Added Nitrogen Chemicals

ChemCatChem, Volume 18, Issue 7, 14 April 2026.
This review maps how electroenzymatic cascades that couple nitrogen‐cycle enzymes with C─N bond forming auxilary enzymes, powered by direct electron transfer (DET) or mediated electron transfer (MET), can upgrade N2 and waste nitrogen streams into value‐added amines, amides, amino acids, and other nitrogen‐based chemicals.
Rohit G. Jadhav, Vamshi Krishna Kamaja, Wassim El Housseini, Monica Brachi, Shelley D. Minteer   +4 more
wiley   +1 more source

Schematic to show the role of choline in one-carbon metabolism intersecting with the methionine-homocysteine cycle.

, 2013
Measured metabolites are shown in orange boxes; enzymes are shown in bolded alphabets. 10-Formyl-THF: 10-formyl-tetrahydrofolate; 5,10-CH = THF: 5,10-methenyltetrahydrofolate; 5,10-CH2-THF: 5,10-methylenetetrahydrofolate; 5-CH3-THF: 5 ...
Sheila M. Innis (310920), Roger A. Dyer (310917), Brian T. F. Wu (310916), D. Janette King (310918), Kelly J. Richardson (310919)   +4 more
core   +1 more source

MTHFD2-mediated redox homeostasis promotes gastric cancer progression under hypoxic conditions

Redox Report
Objectives: Cancer cells undergo metabolic reprogramming to adapt to high oxidative stress, but little is known about how metabolic remodeling enables gastric cancer cells to survive stress associated with aberrant reactive oxygen species (ROS ...
Hai-Yu Mo, Ruo-Bing Wang, Meng-Yao Ma, Yi Zhang, Xin-Yu Li, Wang-Rong Wen, Yi Han, Tian Tian   +7 more
doaj   +1 more source

Identification of Proteins and Genes Expressed by Methylophaga thiooxydans During Growth on Dimethylsulfide and Their Presence in Other Members of the Genus

Frontiers in Microbiology, 2019
Dimethylsulfide is a volatile organic sulfur compound that provides the largest input of biogenic sulfur from the oceans to the atmosphere, and thence back to land, constituting an important link in the global sulfur cycle.
Eileen Kröber, Hendrik Schäfer
doaj   +1 more source

Reprogramming SREBP1‐dependent lipogenesis and inflammation in high‐risk breast with licochalcone A: A novel path to cancer prevention

International Journal of Cancer, Volume 158, Issue 7, Page 1927-1940, 1 April 2026.
What's new? Endocrine drugs repurposed from treatment protocols are the primary medications available for breast cancer (BC) prevention in at‐risk women. Adverse effects, however, significantly minimize uptake and prevention impact. Here, the authors investigated licochalcone A (LicA), a non‐endocrine anti‐inflammatory agent with reported hematologic ...
Atieh Hajirahimkhan, Elizabeth T. Bartom, Carolina H. Chung, Xingyu Guo, Kyli Berkley, Seyyedmohsen Hosseinibarkooie, Zahra Assadi, Shao Huan Samuel Weng, Raymond Moellering, Oukseub Lee, Ruohui Chen, Wonhwa Cho, Sriram Chandrasekaran, Susan E. Clare, Seema A. Khan   +14 more
wiley   +1 more source

The evolution path of C-1-tetrahydrofolate synthase in eukaryotic representatives including M. extorquens, S. aureus, S. cerevisiae, D. melanogaster, D. rerio, X. laevis, M. musculus, H. sapiens.

, 2012
It illustrated how three independent proteins (domains) fused and mutated during the evolutionary path, which resulted in the gain and loss of multiple-functionality.
Wei-Juan Huang (157911), Zhi-Liang Ji (19314), Quan Zou (157931), Xian-Ying Cheng (157908), Jing-Xian Zhang (157919), Hai-Lei Zhang (157916), Shi-Chang Hu (157913), Hong-Huang Lin (157922), Yu-Zong Chen (157926), Hao Wang (39217)   +9 more
core   +1 more source