Results 71 to 80 of about 8,933 (186)

MOESM9 of Combining loss of function of FOLYLPOLYGLUTAMATE SYNTHETASE1 and CAFFEOYL-COA 3-O-METHYLTRANSFERASE1 for lignin reduction and improved saccharification efficiency in Arabidopsis thaliana

, 2019
Additional file 9: Fig. S5. Schematic representation of shikimate pathway, aromatic amino acids (AAA) pathway, and lignin pathway association with C1 metabolism. Adapted from the following papers [13, 17, 37, 43, 93–98].
Nikki Howard (6665162), Nancy Engle (3436811), Arthur Ragauskas (19610), Elison Blancaflor (3416690), Yunqiao Pu (678767), Guifen Li (416172), Avinash Srivastava (3416675), Timothy Tschaplinski (3436805), Richard Dixon (3416687), Jaime Barros (6665153), Yuhong Tang (56216), Mitch Lecoultre (6665156), Hongli Xie (6665141), Richard Nelson (3510236), Chang Yoo (3436814), Michael Hahn (346193), Liang Sun (92795), Sivakumar Pattathil (282269), Sivasankari Venketachalam (6665147)   +18 more
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Gut Luminal Exosomes in Young and Old Mice: Multi‐Omic Characteristics and Regulation of Gut Permeability

Aging Cell, Volume 25, Issue 4, April 2026.
This graphical abstract shows that gut luminal exosomes (LFEs) change with aging, with old mice producing LFEs that disrupt gut barrier integrity, alter microbiome composition, and promote insulin resistance. In contrast, LFEs from young mice improve gut barrier function and metabolic health, and transferring these LFEs can partially reverse age ...
Abdelnaby Khalyfa, Lyu Zhen, Trupti Joshi, David Gozal   +3 more
wiley   +1 more source

Wood-Ljungdahl pathway and involved genes of C. difficile 630.

, 2013
ACS, acetyl-CoA synthase; CODH, carbon monoxide dehydrogenase; CoFeS, corrinoid-iron-sulfur protein; THF, tetrahydrofolate.
Melanie Straub (405398), Peter Dürre (405399), Michael Köpke (405397)   +2 more
core   +1 more source

The role of the folate pathway in pancreatic cancer risk.

PLoS ONE, 2018
BackgroundPancreatic cancer is the third leading cause of cancer related deaths in the United States. Several dietary factors have been identified that modify pancreatic cancer risk, including low folate levels.
Shirisha Chittiboyina, Zhongxue Chen, E Gabriela Chiorean, Lisa M Kamendulis, Barbara A Hocevar   +4 more
doaj   +1 more source

The Role of One‐Carbon Metabolism in Cancer and Its Therapeutic Significance

MedComm – Oncology, Volume 5, Issue 1, March 2026.
One‐Carbon metabolism in T‐cell activation and tumor competition. T‐cell activation shifts metabolic pathways, promoting anabolic metabolism and bioenergetic capacity. One‐carbon metabolism plays a crucial role in histone and DNA methylation in activated T cells.
Yuting Jiang, Guoliang Zhou, Qian Zhang, Shengtao Zhou   +3 more
wiley   +1 more source

Alternative Pathway for Methyl Supply through the Coupling of SHMT1 and PEMT to Maintain Astrocytic Homeostasis in Parkinson's Disease

Advanced Science, Volume 13, Issue 7, 3 February 2026.
In Parkinson's disease, SHMT1 downregulation disrupts its interaction with PEMT in astrocytes, reducing SAM levels. This leads to H3K4me1 hypomethylation and decreased Slc1a2/Glul expression, ultimately exacerbating neuroexcitotoxicity and dopaminergic neuron loss.
Yue‐Han Chen, Rong‐Xin Zhu, Nuo‐Xi Zhang, Ting‐Ting Sun, Xi‐Wei Zhang, Yu‐Jie Zhao, Ben‐Yu He, Hang Yao, Ren‐Hong Du, Lei Cao, Wen‐Bin Zhang, Wei‐Guo Liu, Yun Cai, Cong Wang, Gang Hu, Yao Wei, Yang Liu, Ming Lu   +17 more
wiley   +1 more source

Arabidopsis 10-formyl tetrahydrofolate deformylases are essential for photorespiration

, 2008
In prokaryotes, PurU (10-formyl tetrahydrofolate [THF] deformylase) metabolizes 10-formyl THF to formate and THF for purine and Gly biosyntheses. The Arabidopsis thaliana genome contains two putative purU genes, At4g17360 and At5g47435.
Collakova, Eva, Gregory, Jesse F, Naponelli, Valeria, Shachar-Hill, Yair, Goyer, Aymeric, Hanson, Andrew D, Krassovskaya, Inga   +6 more
core   +1 more source

Metformin‐Mediated Glycaemic Regulation as a Potential Strategy for Breast Cancer Prevention

Cancer Medicine, Volume 15, Issue 2, February 2026.
Metformin (MET), a common antihyperglycemic drug, shows promising anti‐cancer effects in breast cancer (BC). It activates adenosine monophosphate‐activated protein kinase (AMPK), regulating cellular energy and inducing cell cycle arrest, anti‐proliferation, and microenvironment alterations.
Ambulugala Gamage Rajika Greshamali Jinadasa, N. D. Amal Wageesha, Sameera R. Samarakoon, Sagarika Ekanayake, H. M. Kasuni Akalanka   +4 more
wiley   +1 more source

Domain structure and function of 10-formyltetrahydrofolate dehydrogenase.

, 1994
10-Formyltetrahydrofolate dehydrogenase catalyzes the NADP(+)-dependent oxidation of 10-formyltetrahydrofolate to CO2 and tetrahydrofolate. Previous studies have shown that the enzyme binds the physiological pentaglutamate form of tetrahydrofolate ...
SCHIRCH V., VILLAR E, BARRA, Donatella, SCHIRCH D, MARAS, Bruno   +4 more
core  

Structure of methylene-tetrahydromethanopterin dehydrogenase from Methylobacterium extorquens AM1

, 2002
NADP-dependent methylene-H4MPT dehydrogenase, MtdA, from Methylobacterium extorquens AM1 catalyzes the dehydrogenation of methylene-tetrahydro-methanopterin and methylene-tetrahydrofolate with NADP(+) as cosubstrate.
Ermler, Ulrich, Grabarse, Wolfgang, Hagemeier, Christoph H., Vorhott, J., Hagemeier, C., Roth, A., Demmer, U., Grabarse, W., Vorholt, J. A., Demmer, Ulrike, Warkentin, Eberhard, Hagemeier, C. H., Warkentin, E., Vorholt, Julia A., Ermler, U. ; https://orcid.org/, Demmer, U. ; https://orcid.org/, Vorholt, J., Vorhott, J. A., Roth, Annette, Ermler, U.   +19 more
core   +1 more source