Results 41 to 50 of about 1,973 (233)

The presence and distribution of reduced folates in Escherichia coli dihydrofolate reductase mutants. [PDF]

, 1990
Escherichia coli DNA photolyase was overproduced and purified from each of two mutant E. coli strains lacking dihydrofolate reductase. The extent of over-production in the mutants was comparable to that seen in the wild type strain.
Hamm-Alvarez, Sarah F, Rajagopalan, KV, Sancar, Aziz   +2 more
core   +2 more sources

Diving Deeper Into Mechanisms of Acrylamide‐Induced Toxicity: RNA Sequencing Reveals Transcriptomic Alteration and Retrotransposon Expression in Drosophila melanogaster

Environmental Toxicology, EarlyView.
ABSTRACT Given the inevitability of human and animal exposure to acrylamide, there is increasing concern regarding its potential health risks. While a number of molecular mechanisms have been proposed, the complexity of acrylamide toxicological pathways and interactions remains incompletely characterized.
Oluwabukola Mary Farodoye, Titilayomi Ayomide Otenaike, Daniela Moreira Mombach, Monica Medeiros Silva, Amos Olalekan Abolaji, Elgion Lucio Da Silva Loreto   +5 more
wiley   +1 more source

A detailed study of methotrexate treatment in ectopic pregnancy [PDF]

, 2020
Methotrexate is a folic acid antagonist, it works by inhibiting the dihydrofolate by interfering with the DNA synthesis. Ectopic pregnancy is a life threatening condition that may cause maternal mortality. The main aim of this review to show the efficacy
R, Alfiya, Shaiju S Dharan, Sowparnika Treasa Sabu   +2 more
core   +2 more sources

Methionine synthase supports tumour tetrahydrofolate pools

Nature Metabolism, 2021
Mammalian cells require activated folates to generate nucleotides for growth and division. The most abundant circulating folate species is 5-methyl tetrahydrofolate (5-methyl-THF), which is used to synthesize methionine from homocysteine via the cobalamin-dependent enzyme methionine synthase (MTR).
Jonathan M. Ghergurovich, Xincheng Xu, Joshua Z. Wang, Lifeng Yang, Rolf-Peter Ryseck, Lin Wang, Joshua D. Rabinowitz   +6 more
openaire   +2 more sources

Red blood cell membrane proteome as a reporter of disease severity, transfusion impact and genetic background in transfusion‐dependent β‐thalassaemia

British Journal of Haematology, EarlyView.
Summary Omics technologies have transformed research in haemoglobinopathies, yet the proteome of RBCs remains largely unexplored in transfusion‐dependent thalassaemia (TDT). In this proteomic analysis, Red blood cell (RBC) membranes from 48 adults with TDT were compared with healthy controls.
Konstantina Theocharaki, Sophia Delicou, Aikaterini Ntzoura‐Kani, Nikolaos Simantiris, Marianna Politou, Veroniki Komninaka, Martina Samiotaki, Jerome Zoidakis, Marianna H. Antonelou   +8 more
wiley   +1 more source

Serum Folate Concentration Corresponding to the Red Blood Cell Folate Threshold for Increased Risk of Neural Tube Defects Among Ethiopian Women of Reproductive Age

Maternal &Child Nutrition, EarlyView.
ABSTRACT Neural tube defects (NTDs) are severe birth defects linked to insufficient maternal folate status during early pregnancy. Red blood cell (RBC) folate concentration is the recommended biomarker for predicting NTD risk, with a threshold of 748 nmol/L using the US Centers for Disease Control and Prevention (CDC) microbiological assay. However, in
Biniyam Tesfaye, Meseret Woldeyohannes, Masresha Tessema, Charles Dale Arnold, Christine M. McDonald, Kenneth H. Brown   +5 more
wiley   +1 more source

Disruption of Asparagine Synthetase Is Associated to Increased Biomass in Lotus japonicus

Plant Biotechnology Journal, EarlyView.
ABSTRACT Asparagine (Asn) constitutes the major form of nitrogen translocated within Lotus japonicus plants. In this work we use knock‐out (KO) LORE1 mutants‐deficient in the asparagine synthetase gene (LjASN1), which is the most highly expressed ASN gene in plants grown under non‐symbiotic (NS) conditions, but much less expressed under symbiotic (S ...
Sara Rosa‐Téllez, Margarita García‐Calderón, David Barbosa Medeiros, Antonio J. Márquez, Alisdair R. Fernie, Marco Betti   +5 more
wiley   +1 more source

Folate bioavailability [PDF]

, 2009
An inadequate folate status is associated with increased risk of anaemia and neural tube defects. In many countries a folate intake below recommendations has been reported for women in childbearing age.
Öhrvik, Veronica
core  

Riboflavin status, MTHFR genotype and blood pressure: current evidence and implications for personalised nutrition [PDF]

, 2016
Clinical deficiency of the B-vitamin riboflavin (vitamin B2) is largely confined to developing countries; however accumulating evidence indicates that suboptimal riboflavin status is a widespread problem across the developed world. Few international data
Hughes, CF, McAuley, E., McNulty, H., Strain, JJ, Ward, M   +4 more
core   +1 more source

DNA Methylation Shapes Seed‐Borne Microbiome and Proteome Responses During Early Maize‐Beneficial Bacteria Interactions

Plant, Cell &Environment, EarlyView.
ABSTRACT Microorganism and plant interactions are crucial for development and environmental adaptation. Plant growth promoting bacteria enhance agricultural productivity in a sustainable manner, while epigenetic modifications such as DNA methylation regulate gene expression and adaptive responses.
Pedro Igor Zocateli, Geovanna Vitória Olímpio, Felipe Astolpho de Almeida, Letícia Oliveira da Rocha, Diego Vinicius de Sena Martins, Sara Sangi, Fábio Lopes Olivares, Elyabe Monteiro de Matos, Juliana Siqueira, Lyderson Facio Viccini, Roberta Pena da Paschoa, Vanildo Silveira, Clícia Grativol   +12 more
wiley   +1 more source