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Carbon-carbon bond formation using aromatics from biomass.
Chem Commun (Camb)Dunås P, Paterson AJ, Lewis SE, Kann N.
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Tetrahydroisoquinolines: A review
Progress in Neuro-Psychopharmacology, 1981Abstract 1. 1. This article reviews some important aspects concerning the chemistry, biochemistry, and pharmacology of Tetrahydroisoquinolines. 2. 2. Special attention is given to the hypothesis which attempts to explain the physiopathology of certain behavioral disorders observed after chronic ingestion of alcohol. 3. 3.
M E, Zarranz de Ysern, L A, Ordoñez
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Biosynthesis of Tetrahydroisoquinoline Antibiotics
Current Topics in Medicinal Chemistry, 2016The tetrahydroisoquinoline (THIQ) alkaloids are naturally occurring antibiotics isolated from a variety of microorganisms and marine invertebrates. This family of natural products exhibit broad spectrum antimicrobial and strong antitumor activities, and the potency of clinical application has been validated by the marketing of ecteinascidin 743 (ET-743)
Gong-Li, Tang +3 more
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New Synthesis of Tetrahydroisoquinolines
Russian Journal of Organic Chemistry, 2022Abstract: The reaction of cyclohexylidenecyanothioacetamide with N,N-dimethylformamide dimethyl acetal was studied. This transformation, depending on the reaction conditions, leads to different results: when the starting reagents are refluxed without a solvent, 3-(methylsulfanyl)-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile is formed, and refluxing in
I. V. Dyachenko +4 more
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Multicomponent Synthesis of Tetrahydroisoquinolines
Organic Letters, 2018A multicomponent synthesis of tetrahydroisoquinolines from carboxylic acids, alkynyl ethers, and dihydroisoquinolines is described. This process features readily available starting materials, simple experimental procedures for achievement of molecule complexity, and structural diversity. The preliminary control experiment and crossover reaction provide
Linwei Zeng +3 more
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Tetrahydroisoquinoline and 1-methyl-tetrahydroisoquinoline as novel endogenous amines in rat brain
Biochemical and Biophysical Research Communications, 1986This is the first report to identify 1,2,3,4-tetrahydroisoquinoline and 1-methyl-1,2,3,4-tetrahydroisoquinoline as endogenous amines from non-treated rat brain. The detection was performed by coupled gas chromatography - multiple ion detection, using heptafluorobutyric anhydride and pentafluoropropionic anhydride as derivatizing reagents.
M, Kohno, S, Ohta, M, Hirobe
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Tetrahydroisoquinolines as MCH-R1 antagonists
Bioorganic & Medicinal Chemistry Letters, 2006A series of potent and selective inhibitors of h-MCH-R1 has been developed based on the piperidine glycineamide compounds I and II. These structurally more rigid tetrahydroisoquinolines (III and IV) showed better pharmacokinetics. The highly potent compounds 12d and 12g displayed excellent rat pk.
T K, Sasikumar +8 more
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Tetrahydroisoquinolines and the serotonergic system
Drug and Alcohol Dependence, 1979Abstract Although its oxidation to acetate overwhelmingly predominates, acetaldehyde (ACH) formed during ethanol metabolism can be “trapped” by condensation with catecholamines (CAs) or DOPA. The condensation products, tetrahydroisoquinolines (TIQs), have been detected in the brains of mice chronically exposed to ethanol [1] and in the urine of ...
J J, Hannigan, M A, Collins
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Optimized synthesis of tetrahydroisoquinoline-hydantoins
Tetrahedron Letters, 2004AbstractFor Abstract see ChemInform Abstract in Full Text.
Julie Charton +4 more
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