Results 1 to 10 of about 10,671 (149)

Synthesis of 1,2,3,4‐Tetrahydroisoquinoline‐3‐Carboxylic Acid‐Embedded Decapeptides: In Silico Studies and In Vitro Evaluation Against Breast Cancer [PDF]

ChemistryOpen
Cancer is a leading cause of mortality worldwide, which has led to further research in developing more effective therapeutics. We synthesized amphipathic cationic peptides incorporating 1,2,3,4‐tetrahydroisoquinoline‐3‐carboxylic acid (Tic acid) into ...
Sunil Tivari, Naurin Lalani, Pritam Bagwe, Prashant Chandole, Ramesh Pawar, Enrique Delgado‐Alvarado, Abdallah Othman Ghnaim, Yashwantsinh Jadeja   +7 more
doaj   +3 more sources

Isolation and X-ray Crystal Structure of Tetrahydroisoquinoline Alkaloids from Calycotome Villosa Subsp. intermedias [PDF]

Molecules, 2004
Two tetrahydroisoquinoline alkaloids were extracted from the alkaloid fraction of a methanol extract of the seeds of Calycotome Villosa Subsp. intermedia.
Mohammed Lachkar, Brahim El Bali, Michael Bolte, Rachid El Alami, Mohamed Bouktaib, Ibtissam Messouri, Ali El Antri   +6 more
doaj   +3 more sources

Structure-guided modification of a lead cholinesterase-targeting oxime to improve peripheral site binding [PDF]

Arhiv za Higijenu Rada i Toksikologiju
Based on our previous study on N‑substituted 2-hydroxyiminoacetamides as cholinesterase-targeting ligands, which highlighted 2-hydroxyimino-N-(3-(4-((2-methyl-1H-imidazol-1-yl)methyl)-1H-1,2,3-triazol-1-yl)-1-phenylpropyl)acetamide as lead compound ...
Maraković Nikola, Probst Nicolas, Čadež Tena, Zandona Antonio   +3 more
doaj   +2 more sources

Synthesis and characterization of metal dithiocarbamate derivatives of (S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline [PDF]

Scientific Reports
Five metal dithiocarbamate complexes [M(PTHIQDTC)2] [where PTHIQDTC is (S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline dithiocarbamate anion and M is Ni(II) (1), Sn(II) (2), Hg(II) (3), Pb(II) (4) and Zn(II) (5)] were synthesized from the reaction of MX2 (X ...
Azim Ziyaei Halimehjani, Vahid Amani, Fatemeh Naseri, Behrouz Notash   +3 more
doaj   +2 more sources

Diastereoselective Synthesis of (–)-6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylic Acid via Morpholinone Derivatives

Molecules, 2023
A simple and convenient synthesis of (–)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid is described, applying a combination of two synthetic methods: the Petasis reaction and Pomeranz–Fritsch–Bobbitt cyclization.
Maria Chrzanowska, Agnieszka Grajewska, Maria D. Rozwadowska   +2 more
doaj   +1 more source

Biological Activities of Tetrahydroisoquinolines Derivatives

Журнал органічної та фармацевтичної хімії, 2023
1,2,3,4-Tetrahydroisoquinoline (THIQ) is a common scaffold of many alkaloids isolated from several plants and mammalian species. THIQ derivatives possess a broad spectrum of biological activities, including antitumor, antitubercular, antitrypanosomal ...
Maryam A. Jordaan, Oluwakemi Ebenezer
doaj   +1 more source

Crystal structure and Hirshfeld surface analysis of 2-{[7-acetyl-4-cyano-6-hydroxy-8-(4-methoxyphenyl)-1,6-dimethyl-5,6,7,8-tetrahydroisoquinolin-3-yl]sulfanyl}-N-phenylacetamide

Acta Crystallographica Section E: Crystallographic Communications, 2021
The title molecule, C29H29N3O4S, adopts a conformation with the two phenyl substituents disposed on opposite sides of the mean plane of the isoquinoline unit.
Eman M. Sayed, Reda Hassanien, Shaaban K. Mohamed, Joel T. Mague, Mehmet Akkurt, Nasser Farhan, Etify A. Bakhite, Safiyyah A. H. Al-Waleedy   +7 more
doaj   +1 more source

Design, Synthesis, and Biological Evaluation of Marine Lissodendrins B Analogues as Modulators of ABCB1-Mediated Multidrug Resistance

Marine Drugs, 2023
Multidrug resistance (MDR) caused by ATP-Binding Cassette Subfamily B Member 1 (ABCB1, P-glycoprotein, P-gp) is a major barrier for the success of chemotherapy in clinics. In this study, we designed and synthesized a total of 19 Lissodendrins B analogues
Chaoming Wang, Jinman Zhang, Xianfeng Wei, Mengke Yang, Weiping Ma, Rilei Yu, Ming Liu, Tao Jiang   +7 more
doaj   +1 more source

Synthesis, Crystal Growth, and Computational Investigation of New Tetrahydroisoquinoline Derivatives Potent against Molecule Nitric Oxide Synthases

Crystals, 2023
In the present work, we describe the synthesis of new tetrahydroisoquinoline derivatives and the crystal structures of two of them. Density functional theory (DFT) investigations at the B3LYP/6-31+G(d,p) level provided their structural reactivity and ...
Youness El Bakri, Shaaban K. Mohamed, Atazaz Ahsin, Subramani Karthikeyan, Suzan Abuelhassan, Abdu E. Abdel-Rahman, Islam S. Marae, Etify A. Bakhite, Joel T. Mague, Rashad Al-Salahi   +9 more
doaj   +1 more source

Synthesis of Cyclic N-Acyl Amidines by [3 + 2] Cycloaddition of N-Silyl Enamines and Activated Acyl Azides

Molecules, 2022
In this study, we describe the synthesis of cyclic N-acyl amidines from readily available N-heteroarenes. The synthetic methodology utilized the versatile N-silyl enamine intermediates from the hydrosilylation of N-heteroarenes for the [3 + 2 ...
Dong Geun Jo, Changeun Kim, Sinjae Lee, Sooyeon Yun, Seewon Joung   +4 more
doaj   +1 more source