Results 21 to 30 of about 10,671 (149)
Salsolinol: an Unintelligible and Double-Faced Molecule—Lessons Learned from In Vivo and In Vitro Experiments [PDF]
, 2017 Salsolinol (1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline) is a tetrahydroisoquinoline derivative whose presence in humans was first detected in the urine of Parkinsonian patients on l-DOPA (l-dihydroxyphenylalanine) medication.
Bugajski, Andrzej +3 more
core +2 more sources
Molecules, 2018 A mild and highly efficient metal-free oxidative α-cyanation of N-acyl/sulfonyl 1,2,3,4-tetrahydroisoquinolines (THIQs) has been accomplished at an ambient temperature via DDQ oxidation and subsequent trapping of N-acyl/sulfonyl iminium ions with (n-
Hong Pyo Kim +4 more
doaj +1 more source
In Silico Design and Selection of New Tetrahydroisoquinoline-Based CD44 Antagonist Candidates
Molecules, 2021 CD44 promotes metastasis, chemoresistance, and stemness in different types of cancer and is a target for the development of new anti-cancer therapies. All CD44 isoforms share a common N-terminal domain that binds to hyaluronic acid (HA).
Angel J. Ruiz-Moreno +3 more
doaj +1 more source
A detailed study of the diastereoselective catalytic hydrogenation of 6-hydroxytetrahydroisoquinoline-(3R)-carboxylic ester intermediates [PDF]
, 2012 A key step towards a highly-selective antagonist of ionotropic glutamate receptors entails the diastereoselective arene hydrogenation of an enantiopure tetrahydroisoquinoline.
Ager, David J., +10 more
core +1 more source
Pharmaceutics, 2022 Hyaluronic acid (HA), through its interactions with the cluster of differentiation 44 (CD44), acts as a potent modulator of the tumor microenvironment, creating a wide range of extracellular stimuli for tumor growth, angiogenesis, invasion, and ...
José M. Espejo-Román +7 more
doaj +1 more source
Synthesis of substituted tetrahydroisoquinolines by lithiation then electrophilic quench [PDF]
, 2016 Substituted N-tert-butoxycarbonyl (Boc)-1,2,3,4-tetrahydroisoquinolines were prepared and treated with n-butyllithium in THF at −50 °C to test the scope of the metallation and electrophilic quench.
Coldham, I. +3 more
core +1 more source
Marine Drugs, 2021 Oceanalin B (1), an α,ω-bipolar natural product belonging to a rare family of sphingoid tetrahydoisoquinoline β-glycosides, was isolated from the EtOH extract of the lyophilized marine sponge Oceanapia sp.
Tatyana N. Makarieva +6 more
doaj +1 more source
The kinetics and mechanism of the organo-iridium catalysed racemisation of amines [PDF]
, 2016 The dimeric iodo-iridium complex [IrCp*I2 ]2 (Cp*=pentamethylcyclopentadiene) is an efficient catalyst for the racemisation of secondary and tertiary amines at ambient and higher temperatures with a low catalyst loading.
A. John Blacker +37 more
core +1 more source
Discovery of a Plant Pictet–Spenglerase With R‐Stereoselectivity
Angewandte Chemie, EarlyView.Strictosidine synthases (STRs) are plant Pictet–Spenglerases catalyzing the coupling of a secoiridoid with tryptamine. All previously characterized strictosidine synthases are strictly S‐selective. Here, we report the discovery of Epi‐STR, an R‐selective STR ortholog from the medicinal plant Pogonopus speciosus.
Clara Morweiser +3 more
wiley +2 more sources
Acta Crystallographica Section E: Crystallographic Communications, 2021 In the title molecule, C28H25Cl2N3O3S, the heterocyclic portion of the tetrahydroisoquinoline unit is planar while the cyclohexene ring adopts a twist-boat conformation.
Mehmet Akkurt +5 more
doaj +1 more source