Results 11 to 20 of about 5,203 (175)
Molecules, 2022 In this study, we describe the synthesis of cyclic N-acyl amidines from readily available N-heteroarenes. The synthetic methodology utilized the versatile N-silyl enamine intermediates from the hydrosilylation of N-heteroarenes for the [3 + 2 ...
Dong Geun Jo +4 more
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Biocatalytic production of tetrahydroisoquinolines [PDF]
Tetrahedron Letters, 2012 The promiscuity of the enzyme norcoclaurine synthase is described. This biocatalyst yielded a diverse array of substituted tetrahydroisoquinolines by cyclizing dopamine with various acetaldehydes in a Pictet-Spengler reaction. This enzymatic reaction may provide a biocatalytic route to a range of tetrahydroisoquinoline alkaloids.
Ruff, Bettina M. +2 more
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Acta Crystallographica Section E: Crystallographic Communications, 2020 In the title spiro compound, C34H30N2O3, the central pyrrolidine ring is fused with the tetrahydroisoquinoline ring, both having distorted envelope conformations, with the flap atoms being C and N, respectively. The methoxyphenyl group is attached to the
Janet Priyavathani Selvaraj +5 more
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Beilstein Journal of Organic Chemistry, 2021 A convenient and simple protocol has been developed for the synthesis of a series of new tetracyclic tetrahydroisoquinoline derivatives, 7,12-dihydro-6,12-methanodibenzo[c,f]-azocine-5-carboxylic acids by three component Petasis reaction with the use of ...
Agnieszka Grajewska +2 more
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Acta Crystallographica Section E: Crystallographic Communications, 2021 In the title molecule, C28H27N3O3S, the heterocyclic portion of the tetrahydroisoquinoline unit is planar and an intramolecular N—H...N hydrogen bond and a C—H...π(ring) interaction help to determine the overall conformation.
Elham A. Al-Taifi +6 more
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Molecules, 2004 Two tetrahydroisoquinoline alkaloids were extracted from the alkaloid fraction of a methanol extract of the seeds of Calycotome Villosa Subsp. intermedia.
Mohammed Lachkar +6 more
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Molecules, 2018 A mild and highly efficient metal-free oxidative α-cyanation of N-acyl/sulfonyl 1,2,3,4-tetrahydroisoquinolines (THIQs) has been accomplished at an ambient temperature via DDQ oxidation and subsequent trapping of N-acyl/sulfonyl iminium ions with (n-
Hong Pyo Kim +4 more
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Synthesis of Some Heterocyclic Compounds Containing Tetrahydroisoquinoline Moiety [PDF]
مجلة التربية والعلم, 2013 This research involves synthesis of some five membered heterocyclic compounds using 1,2,3,4-tetrahydroisoquinoline as a synthone. The initial step in this research involves the reaction of 1,2,3,4-tetrahydroisoquinoline with ethyl chloroacetate to form ...
Mohammad Al-Iraqi, Ahmad Najem
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In Silico Design and Selection of New Tetrahydroisoquinoline-Based CD44 Antagonist Candidates
Molecules, 2021 CD44 promotes metastasis, chemoresistance, and stemness in different types of cancer and is a target for the development of new anti-cancer therapies. All CD44 isoforms share a common N-terminal domain that binds to hyaluronic acid (HA).
Angel J. Ruiz-Moreno +3 more
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Pharmaceutics, 2022 Hyaluronic acid (HA), through its interactions with the cluster of differentiation 44 (CD44), acts as a potent modulator of the tumor microenvironment, creating a wide range of extracellular stimuli for tumor growth, angiogenesis, invasion, and ...
José M. Espejo-Román +7 more
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