Results 31 to 40 of about 10,671 (149)

Synthesis, Functionalization, and Reactivity of Vinyl Sulfondiimidamides

Angewandte Chemie, EarlyView.
Combining unsymmetrical sulfurdiimide reagents (R‐NSN‐R1) and Grignard reagents, followed by oxidative amination, delivers a series of vinyl sulfondiimidamides. Reactivity with cysteine and lysine derivatives is shown, and the cysteine reactivity is mapped in detail. Variation of the two imidic N‐substituents can be used to tune reactivity of these new
Katherine G. Rodden, Agamemnon E. Crumpton, Samuel E. Dalton, Michael A. Clegg, Michael C. Willis   +4 more
wiley   +2 more sources

The Pictet-Spengler Reaction Updates Its Habits

Molecules, 2020
The Pictet-Spengler reaction (P-S) is one of the most direct, efficient, and variable synthetic method for the construction of privileged pharmacophores such as tetrahydro-isoquinolines (THIQs), tetrahydro-β-carbolines (THBCs), and polyheterocyclic ...
Andrea Calcaterra, Laura Mangiardi, Giuliano Delle Monache, Deborah Quaglio, Silvia Balducci, Simone Berardozzi, Antonia Iazzetti, Roberta Franzini, Bruno Botta, Francesca Ghirga   +9 more
doaj   +1 more source

N-benzotriazol-1-yl-methyl-1,2,3,4-tetrahydroisoquinoline [PDF]

, 1999
Benzotriazole-mediated heteroalkylations have been explored for many synthetic pathways.[...
Baldey, Sara, Locher, Cornelia, Peerzada, Naseem   +2 more
core   +1 more source

Visible-light promoted atom transfer radical addition-elimination (ATRE) reaction for the synthesis of fluoroalkylated alkenes using DMA as electron-donor [PDF]

, 2020
Here, we describe a mild, catalyst-free and operationally-simple strategy for the direct fluoroalkylation of olefins driven by the photochemical activity of an electron donor-acceptor (EDA) complex between DMA and fluoroalkyl iodides.
Gu, Jiwei, He, Chun-Yang, Li, Xiao-Fei, Mao, Ting, Wang, Le, Xu, Wen-Wen   +5 more
core   +2 more sources

2-[(1R,3S)-6,7-Dimethoxy-1-phenyl-1,2,3,4-tetrahydroisoquinolin-3-yl]-4-phenyl-1,3-thiazole

Acta Crystallographica Section E, 2011
In the title compound, C26H24N2O2S, the dihedral angle between the thiazole ring and the adjacent phenyl ring is 3.02 (15)°. The N-containing six-membered ring of the tetrahydroisoquinoline unit adopts a half-chair conformation.
Glenn E. M. Maguire, Hendrik G. Kruger, Thavendran Govender, Venugopala Katharigatta, Sunayna Pawar   +4 more
doaj   +1 more source

Microwave-assisted synthesis of 1,2,3,4-tetrahydroisoquinoline sulfonamide derivatives and their biological evaluation [PDF]

Journal of the Serbian Chemical Society, 2021
Herein we report an alternative eco-friendly method for the synthesis of 1,2,3,4-tetrahydroisoquinoline sulfonamide derivatives. All obtained compounds were screened for their in vitro inhibition of albumin denaturation, antioxidant, antitryptic and ...
Manolov Stanimir P., Ivanov Iliyan I., Bojilov Dimitar G.   +2 more
doaj   +1 more source

Synthesis and Neurotropic Activity of Novel Quinoline Derivatives

Molecules, 1997
Hydroxyalkyl and carboxyalkyl derivatives of silatetrahydroisoquinoline, tetrahydroisoquinoline and tetrahydroquinoline have been synthesized. Their neurotropic activity has been investigated.
Skaidrite Germane, Alla Zablotskaya, Izolda Segal, Edmunds Lukevics   +3 more
doaj   +1 more source

Crystal structure and Hirshfeld surface analysis of 2-{[7-acetyl-4-cyano-6-hydroxy-8-(4-methoxyphenyl)-1,6-dimethyl-5,6,7,8-tetrahydroisoquinolin-3-yl]sulfanyl}acetic acid ethyl ester

Acta Crystallographica Section E: Crystallographic Communications, 2022
In the title molecule, C25H28N2O5S, (alternative name ethyl 2-{[7-acetyl-4-cyano-6-hydroxy-8-(4-methoxyphenyl)-1,6-dimethyl-5,6,7,8-tetrahydroisoquinolin-3-yl]sulfanyl}acetate) the 4-methoxyphenyl group is disposed on one side of the bicyclic core and ...
Elham A. Al-Taifi, Islam S. Marae, Yasser A. El-Ossaily, Shaaban K. Mohamed, Joel T. Mague, Mehmet Akkurt, Etify A. Bakhite   +6 more
doaj   +1 more source

Structure–activity study of N-((trans)-4-(2-(7-cyano-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)cyclohexyl)-1H-indole-2-carboxamide (SB269652), a bitopic ligand that acts as a negative allosteric modulator of the dopamine D2 receptor [PDF]

, 2015
We recently demonstrated that SB269652 (1) engages one protomer of a dopamine D2 receptor (D2R) dimer in a bitopic mode to allosterically inhibit the binding of dopamine at the other protomer.
Ananthan S., Armstrong D., Arthur Christopoulos, Ballesteros J. A., Ben Capuano, Berque-Bestel I., Bondi A., Bordwell F. G., Chien E. Y. T., Christopher Draper-Joyce, Christopoulos A., Christopoulos A., Conn P. J., Crosby I. T., Darras F. H., Davis K. L., Ehrlich K., Gogoi S., Gottlieb H. E., Guo W., J. Robert Lane, Jeremy Shonberg, Kapur S., Kenakin T., Keov P., Kühhorn J., Lane J. R., Lane J. R., Leach K., Löber S., Mammen M., May L. T., Micheli F., Milligan G., Mohr K., Mérour J.-Y., Narlawar R., Newman A. H., Newman A. H., Newman A. H., Onaran H. O., Peter J. Scammells, Politzer P., Portoghese P. S., Reavill C., Seeman P., Shailesh N. Mistry, Shirhatti P. R., Shonberg J., Shonberg J., Shonberg J., Silvano E., Smith N. J., Stemp G., Szabo M., Valant C., Voth A. R., Wang M., Wilcken R., Wootten D., Zawarynski P., Zhang A.   +61 more
core   +2 more sources

4-[(2,4-Dimethyl-1,3-oxazol-5-yl)methyl]-4-hydroxy-2-methylisoquinoline-1,3(2H,4H)-dione

Acta Crystallographica Section E, 2010
In the title isoquinolinedione derivative, C16H16N2O4, the piperidine ring in the tetrahydroisoquinoline unit adopts a half-boat conformation. The essentially planar oxazole ring [maximum deviation = 0.004 (2) Å] is inclined ...
Hoong-Kun Fun, Jia Hao Goh, Haitao Yu, Yan Zhang   +3 more
doaj   +1 more source