Results 51 to 60 of about 5,203 (175)

Safracin B as a Synthetic Linchpin: From Natural Product to Drug Intermediate and Beyond

European Journal of Organic Chemistry, Volume 29, Issue 27, 17 July 2026.
Safracin B is employed as a key precursor for the streamlined preparation of cyanosafracin B and safracin A. Careful tuning of the reaction parameters affords these derivatives in high efficiency, and full nuclear magnetic resonance signal assignments are established for the complex safracin frameworks.
Paolo Orlando, Simone Borsoi, Valerio Fasano, Andrea Citarella, Pietro Allegrini, Daniele Passarella   +5 more
wiley   +1 more source

Stafib‐2‐CR: an Improved Nanomolar and Selective Inhibitor of the Transcription Factor STAT5b Developed by Conformational Restriction of Stafib‐2

Chemistry – A European Journal, Volume 32, Issue 26, 11 July 2026.
Conformational restriction strategies to increase the activity and selectivity of the STAT5b inhibitor Stafib‐2 are presented. The best conformationally restricted inhibitor Stafib‐2‐CR has threefold higher activity against STAT5b than Stafib‐2. A cell‐permeable prodrug of Stafib‐2‐CR inhibits phosphorylation of STAT5b in cultured human leukemia cells ...
Theresa Münzel, Angela Berg, Christoph Protzel, Sylvie Schäfer, Alexander Jensen‐Feinhals, Thorsten Berg   +5 more
wiley   +1 more source

2-(4-Iodophenyl)-1,2,3,4-tetrahydroisoquinoline-1-carbonitrile

Acta Crystallographica Section E, 2011
In the title compound, C16H13IN2, the benzene ring of the tetrahydroisoquinoline moiety makes a dihedral angle of 45.02 (9)° with the benzene ring of the 4-iodophenyl fragment.
Yanni Ma, Lili Du, Qi Zhang, Fangjun Cao, Le Zhou   +4 more
doaj   +1 more source

Design, Synthesis, and Photophysical Studies of Functionalized Polyaromatic Isonitriles as Visible Light Photoredox Catalysts

European Journal of Organic Chemistry, Volume 29, Issue 25, 4 July 2026.
A new series of structurally rich polyaromatic isonitriles is presented as photoredox catalysts. Their photophysical properties are investigated by UV–Vis absorption and fluorescence measurements, combined with experimental and theoretical studies to evaluate both ground‐ and excited‐state redox properties.
Cristina Martini, Camilla Russo, Jussara Amato, Carmine Volpe, Francesca Brunelli, Laurence Grimaud, Maxime R. Vitale, Greta Donati, Andrea Basso, Mariateresa Giustiniano   +9 more
wiley   +1 more source

Accessing simply-substituted 4-hydroxytetrahydroisoquinolines via Pomeranz–Fritsch–Bobbitt reaction with non-activated and moderately-activated systems

Beilstein Journal of Organic Chemistry, 2017
Background: 1,2,3,4-Tetrahydroisoquinolines (THIQs) are common motifs in alkaloids and in medicinal chemistry. Synthetic access to THIQs via the Pomeranz–Fritsch–Bobbit (PFB) methodology using mineral acids for deactivated, electron-poor aromatic systems,
Marco Mottinelli, Mathew P. Leese, Barry V. L. Potter   +2 more
doaj   +1 more source

4-[(2,4-Dimethylthiazol-5-yl)methyl]-4-hydroxy-2-methylisoquinoline-1,3(2H,4H)-dione

Acta Crystallographica Section E, 2010
In the title isoquinolinedione derivative, C16H16N2O3S, the piperidine ring in the tetrahydroisoquinoline ring system adopts a distorted envelope conformation.
Hoong-Kun Fun, Jia Hao Goh, Haitao Yu, Yan Zhang   +3 more
doaj   +1 more source

Discovery of a Potent Fluorescence Polarization Probe for Identifying USP1 Allosteric Inhibitors

Advanced Science, Volume 13, Issue 39, 13 July 2026.
This study presents the first ubiquitin‐specific protease 1 (USP1) allosteric fluoroprobe and fluorescence polarization assay, enabling the differentiation of allosteric and catalytic site inhibitors. Further, a novel class of tetrahydroisoquinoline‐based USP1 inhibitors is designed, with compound 14a (USP1 IC50 = 29.9 nM) showing strong selectivity ...
Jiawei Cheng, Peipei Wang, Pengfei Wang, Jiamin Wang, Baiyang Li, Daqing Fang, Jian He, Xiaobei Hu, Weijuan Kan, Yubo Zhou, Chunpu Li, Jia Li, Hong Liu   +12 more
wiley   +1 more source

Palladium-Catalyzed α-Arylation of Esters: Synthesis of the Tetrahydroisoquinoline Ring

Reactions
The palladium-catalyzed cross-coupling reaction used for carbon–carbon bond formation is one of the most commonly applied reactions in modern organic synthesis.
Georgeta Serban, Faïza Diaba
doaj   +1 more source

4-[(2,5-Dimethyl-1,3-thiazol-4-yl)methyl]-4-hydroxy-2-methylisoquinoline-1,3(2H,4H)-dione

Acta Crystallographica Section E, 2010
In the title isoquinolinedione compound, C16H16N2O3S, the piperidine ring in the tetrahydroisoquinoline ring system adopts a half-boat conformation. The essentially planar thiazole ring [maximum deviation = 0.007 (2) Å] makes
Hoong-Kun Fun, Jia Hao Goh, Haitao Yu, Yan Zhang   +3 more
doaj   +1 more source

One-pot functionalisation of N-substituted tetrahydroisoquinolines by photooxidation and tunable organometallic trapping of iminium intermediates

Beilstein Journal of Organic Chemistry, 2014
Nucleophilic trapping of iminium salts generated via oxidative functionalisation of tertiary amines is well established with stabilised carbon nucleophiles.
Joshua P. Barham, Matthew P. John, John A. Murphy   +2 more
doaj   +1 more source