Results 51 to 60 of about 10,671 (149)

Metal-organic framework composites with luminescent gold(III) complexes. Strongly emissive and long-lived excited states in open air and photo-catalysis [PDF]

, 2015
The encapsulation of luminescent gold(III) complexes by metal–organic frameworks (MOFs) lays the groundwork for new phosphorescent materials with activities that are not readily achieved by the host MOF materials or gold(III) complexes alone.
Chan, KT, Che, CM, Su, Z, Sun, C, To, WP, Wang, XL   +5 more
core   +1 more source

Stafib‐2‐CR: an Improved Nanomolar and Selective Inhibitor of the Transcription Factor STAT5b Developed by Conformational Restriction of Stafib‐2

Chemistry – A European Journal, EarlyView.
Conformational restriction strategies to increase the activity and selectivity of the STAT5b inhibitor Stafib‐2 are presented. The best conformationally restricted inhibitor Stafib‐2‐CR has threefold higher activity against STAT5b than Stafib‐2. A cell‐permeable prodrug of Stafib‐2‐CR inhibits phosphorylation of STAT5b in cultured human leukemia cells ...
Theresa Münzel, Angela Berg, Christoph Protzel, Sylvie Schäfer, Alexander Jensen‐Feinhals, Thorsten Berg   +5 more
wiley   +1 more source

Synthesis of bioactive compounds. Studies of their attachment to nanoparticles [PDF]

, 2017
The 1-aryl tetrahydroisoquinolines have attracted great attention in medicinal chemistry due to their biological activity. These compounds present antitumor, anti-HIV and antibacterial activities.
Díaz, Amelia, Lucena-Serrano, Ana, Lucena-Serrano, Cristina, López-Romero, Juan Manuel, Valpuesta-Fernandez, Maria   +4 more
core  

Identification and analysis of conserved pockets on protein surfaces [PDF]

, 2013
BACKGROUND: The interaction between proteins and ligands occurs at pockets that are often lined by conserved amino acids. These pockets can represent the targets for low molecular weight drugs.
Antonella Correra, Giuseppina Andreotti, Marco Cammisa, Maria Vittoria Cubellis   +3 more
core   +1 more source

Design, Synthesis, and Photophysical Studies of Functionalized Polyaromatic Isonitriles as Visible Light Photoredox Catalysts

European Journal of Organic Chemistry, EarlyView.
A new series of structurally rich polyaromatic isonitriles is presented as photoredox catalysts. Their photophysical properties are investigated by UV–Vis absorption and fluorescence measurements, combined with experimental and theoretical studies to evaluate both ground‐ and excited‐state redox properties.
Cristina Martini, Camilla Russo, Jussara Amato, Carmine Volpe, Francesca Brunelli, Laurence Grimaud, Maxime R. Vitale, Greta Donati, Andrea Basso, Mariateresa Giustiniano   +9 more
wiley   +1 more source

7,7′-(1,4-Phenylene)bis(2-benzyl-3-(3,4-dihydroisoquinolin-2(1H)-yl)-6-(4-methoxybenzyl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one)

Molbank
The multicomponent synthesis of a novel and highly symmetric polyheterocycle based on the pyrrolo[3,4-b]pyridin-5-one core incorporating the privileged tetrahydroisoquinoline moiety is described.
Roberto E. Blanco-Carapia, Alejandro Islas-Jácome, Eduardo González-Zamora   +2 more
doaj   +1 more source

6,7-Dimethoxy-2-phenethyl-1,2,3,4-tetrahydroisoquinoline amides and corresponding ester isosteres as multidrug resistance reversers

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
Aiming to deepen the structure–activity relationships of the two P-glycoprotein (P-gp) modulators elacridar and tariquidar, a new series of amide and ester derivatives carrying a 6,7-dimethoxy-2-phenethyl-1,2,3,4-tetrahydroisoquinoline scaffold linked to
Laura Braconi, Gianluca Bartolucci, Marialessandra Contino, Niccolò Chiaramonte, Roberta Giampietro, Dina Manetti, Maria Grazia Perrone, Maria Novella Romanelli, Nicola Antonio Colabufo, Chiara Riganti, Silvia Dei, Elisabetta Teodori   +11 more
doaj   +1 more source

Promising activity of tetrahydroisoquinolines against multidrug-resistant clinical Salmonella isolates and cytotoxicity against monkey kidney cells

Scientific African, 2022
The high burden of Salmonella infections has been aggravated by the emergence and spread of multidrug-resistant strains affecting almost all antibiotic classes recommended for treatment.
Joelle Ngo Hanna, Rita A. Ndip, Moses N. Ngemenya, Casey R. Simons, Flavien A. A. Toze, Stephen M. Ghogomu, James A. Mbah   +6 more
doaj   +1 more source

Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt

British Journal of Pharmacology, EarlyView.
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown, Alan Armstrong, David J. Mann   +2 more
wiley   +1 more source

Antiplasmodial ealapasamines A-C,'mixed' naphthylisoquinoline dimers from the Central African liana Ancistrocladus ealaensis [PDF]

, 2017
Three unusual heterodimeric naphthylisoquinoline alkaloids, named ealapasamines A-C (1-3), were isolated from the leaves of the tropical plant Ancistrocladus ealaensis J. Léonard.
Bringmann, Gerhard, Brun, Reto, Feineis, Doris, Kaiser, Marcel, Mudogo, Virima, Tshitenge, Dieudonné Tshitenge   +5 more
core   +1 more source