Synthesis of New 1,2,3,4-Tetrahydroquinoline Hybrid of Ibuprofen and Its Biological Evaluation
Molbank, 2022 Herein we report the obtaining of 1-(3,4-dihydroquinolin-1(2H)-yl)-2- (4-isobutylphenyl)propan-1-one and its characterization. The newly obtained hybrid and its derivatives (hybrids of ibuprofen with 1,2,3,4-tetrahydroisoquinoline, and piperidine) were ...
Stanimir Manolov +2 more
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Stereochemical studies on protonated bridgehead amines. ^1H NMR determination of cis and trans B-C ring-fused structures for salts of hexahydropyrrolo [2,1-a] isoquinolines and related C ring homologs. Capture of unstable ring-fused structures in the solid state [PDF]
, 1989 Acid-addition salts of tricyclic isoquinolines 2a/b, 3a/b, 4a-4c, 5, 6a/b, 7, 8a/b, 9a/b, and 17a/b were studied by high-field ^1H NMR in CDCl_3 solution.
Inners, Ruth R. +6 more
core
Palladium-Catalyzed α-Arylation of Esters: Synthesis of the Tetrahydroisoquinoline Ring
ReactionsThe palladium-catalyzed cross-coupling reaction used for carbon–carbon bond formation is one of the most commonly applied reactions in modern organic synthesis.
Georgeta Serban, Faïza Diaba
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Synthesis of C3/C1-Substituted Tetrahydroisoquinolines
Molecules, 2015 A broad biological screening of the natural alkaloid N-methylisosalsoline (2) extracted from Hammada scoparia leaves against a panel of human and parasitic proteases revealed an interesting activity profile of 2 towards human 20S proteasome. This outcome
Mohamed Mihoubi +8 more
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Alkaloids from marine ascidians [PDF]
, 2011 About 300 alkaloid structures isolated from marine ascidians are discussed in term of their occurrence, structural type and reported pharmacol. activity.
FATTORUSSO, ERNESTO +2 more
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A novel method for the synthesis of 1-aryltetrahydroisoquinolines [PDF]
, 2017 Carbenium ions generated from substituted benzhydryls using acid catalysis undergo smooth intramolecular trapping by pendant sulfonamide groups to provide excellent yields of 1 ...
Abdel-Fattah, Hanan A. +5 more
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Chemistry &Biodiversity, Volume 23, Issue 4, April 2026.ABSTRACT Cinnamaldehyde (CA), a major component of Cinnamomum spp. essential oils, has recognized bioactivity, including possible analgesic effects. However, its acute antinociceptive mechanisms remain unclear. This study assessed the influence of CA (15, 30, and 60 mg/kg, p.o.) on locomotor and exploratory behaviors via rotarod and open field tests in
Renaly I. de A. Rêgo +10 more
wiley +1 more source
Trisubstituted Pyrimidines as Efficacious and Fast-acting Antimalarials [PDF]
, 2016 In this paper we describe the optimization of a phenotypic hit against Plasmodium falciparum, based on a trisubstituted pyrimidine scaffold. This led to compounds with good pharmacokinetics and oral activity in a P. berghei mouse model of malaria.
Achim Porzelle +30 more
core +7 more sources
Research Progress of Polyoxometalate‐Integrated Frameworks: Syntheses, Properties, and Applications
ChemistryEurope, Volume 4, Issue 4, April 2026.This review systematically summarizes the integration of polyoxometalates with covalent organic frameworks, metal‐organic frameworks, hydrogen‐bonded organic frameworks, and emerging porous hosts. It highlights synergistic effects, synthesis strategies, and applications in catalysis, energy storage, sensing, and biomedicine, while addressing current ...
De‐Yin Wang +6 more
wiley +1 more source
2-(4-Iodophenyl)-1,2,3,4-tetrahydroisoquinoline-1-carbonitrile
Acta Crystallographica Section E, 2011 In the title compound, C16H13IN2, the benzene ring of the tetrahydroisoquinoline moiety makes a dihedral angle of 45.02 (9)° with the benzene ring of the 4-iodophenyl fragment.
Yanni Ma +4 more
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