Hypocretin-1 receptors regulate the reinforcing and reward-enhancing effects of cocaine: pharmacological and behavioral genetics evidence. [PDF]
, 2012 Considerable evidence suggests that transmission at hypocretin-1 (orexin-1) receptors (Hcrt-R1) plays an important role in the reinstatement of extinguished cocaine-seeking behaviors in rodents.
Fowler, Christie D +3 more
core +3 more sources
Concise total syntheses of (–)-jorunnamycin A and (–)-jorumycin enabled by asymmetric catalysis [PDF]
, 2019 The bis-tetrahydroisoquinoline (bis-THIQ) natural products have been studied intensively over the past four decades for their exceptionally potent anticancer activity, in addition to strong gram-positive and -negative antibiotic character.
Allan, Kevin M. +16 more
core
Chiral Bronsted Acid-Catalyzed Enantioselective alpha-Amidoalkylation Reactions: A Joint Experimental and Predictive Study, [PDF]
, 2016 Enamides with a free NH group have been evaluated as nucleophiles in chiral Bronsted acid-catalyzed enantioselective alpha-amidoalkylation reactions of bicyclic hydroxylactams for the generation of quaternary stereocenters.
Aranzamendi Uruburu, Eider +4 more
core +3 more sources
Acta Crystallographica Section E, 2009 The title compound, C33H29N3O5, was synthesized by the reaction of racemic trans-2-benzyl-3-(2-furyl)-1-oxo-1,2,3,4-tetrahydroisoquinoline-4-carboxylic acid, l-tryptophan methyl ester and diisopropylcarbodiimide in dry dichloromethane.
Zeliha Baktır +4 more
doaj +1 more source
From Ethanol to Salsolinol: Role of Ethanol Metabolites in the Effects of Ethanol [PDF]
, 2016 In spite of the global reputation of ethanol as the psychopharmacologically active ingredient of alcoholic drinks, the neurobiological basis of the central effects of ethanol still presents some dark sides due to a number of unanswered questions related ...
Acquas, E, Peana, At, Porru, S, Rosas, M
core +2 more sources
Acid Catalyzed Formation of C–C and C–S Bonds via Excited State Proton Transfer
Molecules, 2019 The behavior of 2-naphthol and 7-bromo-2-naphthol as organic photoacids are exploited in organic synthesis for the preparation of benzyl sulfides (using a trichloroacetimidate derivative as the starting substrate) and polycyclic amines via acid catalyzed
Alessandro Strada +3 more
doaj +1 more source
Syntheses, transformations and applications of aminonaphthol derivatives prepared via modified Mannich reactions [PDF]
, 2013 A special alteration is the three-component modi fi ed Mannich reaction (mMR), in which formaldehyde is replaced by an aromatic aldehyde, the secondary amine by ammonia, and the C e H acid by an electron-rich aromatic compound such as 1- or 2 ...
Fülöp, Ferenc, Szatmári, István
core +1 more source
1,2,3,4-Tetrahydroisoquinoline-2-sulfonamide
Acta Crystallographica Section E, 2008 The title compound, C9H12N2O2S, is a useful precursor of a variety of modified sulfonamide molecules. Due to the importance of these molecules in biological systems (antibacterials, antidepressants and many other applications), there is a growing ...
Carole Barbey +3 more
doaj +1 more source
The effects of structural modifications on sigma receptor binding [PDF]
The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf ...
Xu, Rong, 1977-
core +1 more source
Preparation of substituted tetrahydroisoquinolines by Pd(II)-catalyzed NH2-directed insertion of Michael acceptors into C-H bonds followed by NH2-conjugated additions [PDF]
, 2017 3,3-Disubstituted tetrahydroisoquinolines are prepared in one step from Michael acceptors and 2-phenylethylamines under Pd catalysis and Ag2CO3 as an oxidant. Presumably, activation of an ortho C-H bond of the aromatic ring with Pd(II) is directed by the
Alamillo, Carla +8 more
core +1 more source